Diagnosis of EBV-Associated Inflammatory Pseudotumor in the Spleen: A Case Report

Abstract

The paper focuses on Epstein-Barr virus (EBV)-associated infl ammatory pseudotumor in the spleen, an extremely rare disease which so far remained undefi ned in the Russian literature. The morphology of it is not characterized by any specifi c features and is represented by a spindlecell component with pronounced infl ammatory infi ltration which complicates diff erential diagnosis. Previously this nosology was regarded within a group of the so-called infl ammatory pseudotumors due to the similarity of the clinical course and radiological presentation with tumor processes. Today the term "infl ammatory pseudotumor" is considered obsolete, since as pathogenesis was being studied within this disease group, the individual forms with similar morphology and diff erent histogenesis were identifi ed. Diff erential diagnosis in the context of additional diagnostic techniques is based in such cases on a wide range of reactive states, benign and malignant tumors.