Diagnosis of dengue fever in North West Italy in travelers from endemic areas: A retrospective study

Burdino, Elisa; Milia, Maria Grazia; Sergi, Giuseppina; Gregori, Gabriella; Allice, Tiziano; Cazzato, Maria Lucia; Lucchini, A; Lipani, Filippo; Calleri, Guido; Orofino, Giancarlo; Perri, Giovanni Di; Ghisetti, Valeria

doi:10.1016/j.jcv.2011.05.011

Cited by 18 publications

(17 citation statements)

References 15 publications

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“…Our search also identified no published prevalence studies or outbreaks in Egypt after 1969 until a dengue outbreak was reported in November 2015 [10]. However, DENV transmission was suggested years prior by a report of two travelers diagnosed with dengue after returning from southern Egypt in 2011 [129] and the identification of Ae . aegypti in southern Egypt that same year [130].…”

Section: Discussionmentioning

confidence: 99%

Dengue in the Middle East and North Africa: A Systematic Review

et al. 2016

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BackgroundDengue virus (DENV) infection is widespread and its disease burden has increased in past decades. However, little is known about the epidemiology of dengue in the Middle East and North Africa (MENA).Methodology / Principal FindingsFollowing Cochrane Collaboration guidelines and reporting our findings following PRISMA guidelines, we systematically reviewed available records across MENA describing dengue occurrence in humans (prevalence studies, incidence studies, and outbreak reports), occurrence of suitable vectors (Aedes aegypti and Aedes albopictus), and DENV vector infection rates. We identified 105 human prevalence measures in 13 of 24 MENA countries; 81 outbreaks reported from 9 countries from 1941–2015; and reports of Ae. aegypti and/or Ae. albopictus occurrence in 15 countries. The majority of seroprevalence studies were reported from the Red Sea region and Pakistan, with multiple studies indicating >20% DENV seroprevalence in general populations (median 25%, range 0–62%) in these subregions. Fifty percent of these studies were conducted prior to 1990. Multiple studies utilized assays susceptible to serologic cross-reactions and 5% of seroprevalence studies utilized viral neutralization testing. There was considerable heterogeneity in study design and outbreak reporting, as well as variability in subregional study coverage, study populations, and laboratory methods used for diagnosis.Conclusions / SignificanceDENV seroprevalence in the MENA is high among some populations in the Red Sea region and Pakistan, while recent outbreaks in these subregions suggest increasing incidence of DENV which may be driven by a variety of ecologic and social factors. However, there is insufficient study coverage to draw conclusions about Aedes or DENV presence in multiple MENA countries. These findings illustrate the epidemiology of DENV in the MENA while revealing priorities for DENV surveillance and Aedes control.

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Section: Discussionmentioning

confidence: 99%

Dengue in the Middle East and North Africa: A Systematic Review

et al. 2016

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“…detritus. Burdino et al (2011) in North West Italy identified two imported cases of DENV infections from South Egypt in patients travelling together, confirming the importance of returning travelers as sentinels of a rapidly changing epidemiology in specific geographic areas. They concluded there must a careful evaluation and follow-up of febrile patients returning from Dengue endemic countries.…”

Section: Introductionmentioning

confidence: 75%

Aedes Aegypti and Dengue Virus Infections

Morsy

2018

Journal of the Egyptian Society of Parasitology

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“…In Italy, a recent retrospective study identified dengue infection in 15 out of 91 travelers from endemic areas (16.5%) [8]. This high rate of imported dengue infection in Italy, as well as in other temperate European and non European countries, where dengue virus is not endemic, is of particular concern since increased mobility of populations, substandard living conditions, ineffective vector control, viral and vector evolution, and climate change could modify the present situation [9]. The alternative dengue vector, Aedes albopictus , seems to be spreading into temperate climates, potentially worsening the global dengue problem [5].…”

Section: Discussionmentioning

confidence: 99%

“…In Italy, for example, the dengue vector Aedes albopticus is represented in the Po river valley in the North West Italy, where imported cases have been recently described [8]. Children represent a significant proportion of the travelling public, accounting for 7% (1.9 million) of travelers living in the US [9]. Classic and severe dengue in children pose a significant burden on endemic countries [10].…”

Section: Discussionmentioning

confidence: 99%

The re-emergence of dengue virus in non-endemic countries: a case series

et al. 2014

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BackgroundDengue has been designated a major international public health problem by the World Health Organization. It is endemic in most tropical and sub-tropical countries, which are also popular tourist destinations. Travelers are at significant risk of acquiring the disease and also contribute to its spread to non-endemic countries where the vector is present. Children represent a particular susceptible category, since they have a higher risk than adults of developing severe dengue.Case presentationWe describe 3 cases of imported dengue fever in Italy in three children (two born in the Philippines and one of Bangladeshi ethnicity) who acquired dengue fever during a recent travel to Southeast Asia, initially not-recognized because of the low index of suspicion of physicians not working in dengue endemic areas. Clinical presentations, differential diagnosis and management of these children are presented and discussed.ConclusionsDue to global urbanization and increased air travel, it is nowadays important that physicians who practice outside of traditionally dengue endemic areas are adept at the recognition of potentially fatal reemerging infectious diseases such as dengue.Electronic supplementary materialThe online version of this article (doi:10.1186/1756-0500-7-596) contains supplementary material, which is available to authorized users.

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Diagnosis of dengue fever in North West Italy in travelers from endemic areas: A retrospective study

Cited by 18 publications

References 15 publications

Dengue in the Middle East and North Africa: A Systematic Review

Dengue in the Middle East and North Africa: A Systematic Review

Aedes Aegypti and Dengue Virus Infections

The re-emergence of dengue virus in non-endemic countries: a case series

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