Diagnosis and treatment of oropharyngeal cancer. Clinical recommendations

Чойнзонов, Е. Л.; Podvyaznikov, S O; Минкин, А. У.; Мудунов, А М; Azizyan, R.I.; Pustynsky, I.N.; Tabolinovskaya, T.; Brzhezovsky, V.Zh.; Алиева, С. Б.

doi:10.21294/1814-4861-2016-15-1-83-87

Siberian Journal of Oncology

2016

DOI: 10.21294/1814-4861-2016-15-1-83-87

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Diagnosis and treatment of oropharyngeal cancer. Clinical recommendations

Е. Л. Чойнзонов¹,

S O Podvyaznikov²,

А. У. Минкин³

et al.

Abstract: КлиничесКие реКомендаЦии. диагностиКа и лечение раКа ротоглотКи е.л. чойнзонов, с.о. подвязников, а.у. минкин, а.м. мудунов, р.и. азизян, и.н. пустынский, т.д. таболиновская, в.ж. бржезовский, с.б. алиева Клинические рекомендации подготовлены на основании материалов научно-практической конференции Проблемной комиссии «Опухоли головы и шеи» Научного совета по злокачественным новообразованиям Отделения медицинских наук Российской академии наук и Министерства здравоохранения РФ, посвященной памяти профессора Алек… Show more

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Possibilities of chemoradiation treatment primary locally advanced head and neck tumors

Гордон¹,

Гулидов²,

Рожнов³

et al. 2018

Onkol. Z. im. P.A. Gercena

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Медицинский радиологический научный центр им. А.Ф. Цыба-филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава России, Обнинск, Россия Представлен обзор литературы по одной из актуальных проблем онкологии-лечению нерезектабельных опухолей органов головы и шеи. Обзор посвящен современным возможностям лечения пациентов с местно-распространенными опухолями. Большинство авторов не учитывают особенности нерезектабельных опухолей. Практически отсутствуют современные данные о применении различных способов радиомодификации. Ключевые слова: нерезектабельные опухоли органов головы и шеи, лучевая терапия, плоскоклеточный рак органов головы и шеи.

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Possibilities of chemoradiation treatment primary locally advanced head and neck tumors

Гордон¹,

Гулидов²,

Рожнов³

et al. 2018

Onkol. Z. im. P.A. Gercena

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The effect of smoking on the immediate effectiveness of induction chemotherapy in the combined treatment of HPV-associated oropharyngeal cancer

Golubev,

Bolotina,

Gevorkov

et al. 2023

Issled. prakt. med. (Print)

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Purpose. Evaluation of the eﬀect of smoking on the immediate eﬀectiveness (achievement of objective response – OR) of induction chemotherapy in patients receiving combined treatment for locally advanced HPV-positive squamous cell carcinoma of the oropharynx.Patients and methods. Sixty-eight patients (51 men and 17 women) with locally advanced squamous cell cancer of the oropharynx associated with papillomavirus were included in the study, which was carried out from 2021 to 2023 at the P. Hertsen Moscow Oncology Research Institute – Branch of the National Medical Research Radiological Centre, Ministry of Health of the Russian Federation, Moscow, Russian Federation and the Municipal Clinical Oncological Hospital № 1 of the Department of Health of Moscow. The patients were divided into 2 equal groups, fully comparable in terms of the main characteristics (smoking history, stage, histological type, and degree of tumour diﬀerentiation). At the ﬁrst stage, patients of the 1st (main) group received de-escalated induction chemotherapy: three 21-day courses according to the TR scheme (docetaxel in the dose of 75 mg/m2 + cisplatin 75 mg/m2); patients of the 2nd (control) group were treated with standard scheme (docetaxel 75 mg/m2 + cisplatin 75 mg/m2 + 5-ﬂuorouracil 1000 mg/m2). Patients in both groups received prophylactic granulocyte colony-stimulating factor. At the second stage, standard chemoradiotherapy was carried out against the background of drug radiomodiﬁcation with carboplatin. Correlation analysis was performed by calculating the Spearman coeﬃcient with Bonferroni correction. Diﬀerences were considered reliable at p < 0.05.Results. When evaluating the objective response to treatment, it was revealed that disease control was achieved in 33 (97 %) patients from group 1 and in all 34 (100 %) patients from group 2. Complete response was observed in 3 (8.8 %) patients from group 1 and 4 (11.8 %) from group 2; partial regression in 22 (64.7 %) and 24 (70.6 %); stabilisation of the tumour process in 8 (23.5 %) and 6 (17.6 %) respectively. Further analysis showed that there was no direct or inverse correlation between smoking and diﬀerentiated level of response (primary lesion, altered lymph nodes); all patients (smokers and those who had never smoked) responded equally eﬀectively to the ﬁrst stage of combined treatment, regardless of the ICT regimen.Conclusion. In our study, no statistically signiﬁcant eﬀect of smoking on the immediate eﬀectiveness of induction chemotherapy in the combined treatment of locally advanced HPV-associated squamous cell carcinoma of the oropharynx regardless of the induction regimen was found. However, a longer follow-up period is needed to evaluate the eﬀect of smoking on long-term oncological outcomes.

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Dental health as a factor of provoking carcinogenesis

Panferova

Кудасова²,

Кочурова³

et al. 2022

Russian Journal of Dentistry

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The review discusses the association between dental health and squamous cell carcinoma of the oral mucosa. Studies for the last few years from the databases of PubMed, MedLine, Cochrane Library, EMBASE, Global Health, CyberLeninka, and eLibrary.Ru were analyzed. Literature sources taken for the review are indexed in Scopus, Web of Science, and RSCI. The causal relationship between the lack of oral sanitation, bad habits, unhealthy lifestyle, oral mucosa damage, microbiome changes, and presence of tumor pathology was considered. Poor-quality dental treatment can cause an oncological burden, and unhygienic sanitation of the cavity is a significant predictor of the occurrence of tumor pathology of the maxillofacial region.

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Diagnosis and treatment of oropharyngeal cancer. Clinical recommendations

Cited by 3 publications

References 0 publications

Possibilities of chemoradiation treatment primary locally advanced head and neck tumors

Possibilities of chemoradiation treatment primary locally advanced head and neck tumors

The effect of smoking on the immediate effectiveness of induction chemotherapy in the combined treatment of HPV-associated oropharyngeal cancer

Dental health as a factor of provoking carcinogenesis

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