Diagnosis and Treatment of Metastatic Disease to the Pancreas

Cortez, Nathaly; Berzosa, Manuel; Mahfouz, Mahmoud; Dvir, Kathrin; Fortuna, Gliceida M Galarza; Ben-David, Kfır

doi:10.1089/lap.2020.0219

Cited by 6 publications

(10 citation statements)

References 22 publications

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“…In general, pancreatic metastasis from distant sites are not commonly seen. Reported frequency of metastatic disease to the pancreas vary between 0.5 and 5% of all pancreatic malignancies 2,3 . PMETs are typically discovered 1–3 years after initial diagnosis of CRC but have been reported to occur as far out as 10 years.…”

Section: Discussionmentioning

confidence: 99%

“…FNA sensitivities for metastatic disease range from 75% to 95% and specificity from 60 to 100%, with accuracy greater than 91% 7,8 . On EUS, metastatic lesions to the pancreas are typically reported as hypoechoic heterogeneous masses with well‐defined margins, with the head of the pancreas being the most common site 2,7,8 . Other findings favoring secondary lesions include multiple lesions, a lack of a retention cyst, main pancreatic duct dilation, and pancreatic atrophy 8 …”

Section: Discussionmentioning

confidence: 99%

“…Treatment options for all pancreatic metastasis are determined by the primary pathology, genetic markers and mutations, stage, and tumor burden. Treatment of pancreatic metastasis of colorectal primary consists of chemotherapy and more recently metastatecomies of solitary lesions, which are recommended on an individual basis 2,3 . It is difficult to comment on the prognosis and survival time of synchronous pancreatic metastasis because of a paucity of data.…”

Section: Discussionmentioning

confidence: 99%

“…7,8 On EUS, metastatic lesions to the pancreas are typically reported as hypoechoic heterogeneous masses with well-defined margins, with the head of the pancreas being the most common site. 2,7,8 Other findings favoring secondary lesions include multiple lesions, a lack of a retention cyst, main pancreatic duct dilation, and pancreatic atrophy. 8 Treatment options for all pancreatic metastasis are determined by the primary pathology, genetic markers and mutations, stage, and tumor burden.…”

Section: Discussionmentioning

confidence: 99%

“…Reported frequency of metastatic disease to the pancreas vary between 0.5 and 5% of all pancreatic malignancies. 2 , 3 PMETs are typically discovered 1–3 years after initial diagnosis of CRC but have been reported to occur as far out as 10 years. They can be detected during initial work‐up for staging, on surveillance imaging, or during evaluation for symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Colonic adenocarcinoma with synchronous metastasis to the pancreas: A case report and literature review

et al. 2022

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Metastatic lesions to the pancreas are a rare entity and make up about 0.5–5% of all pancreatic malignancies. Synchronous pancreatic metastasis is even less frequently reported. Before the widespread use of advanced endoscopic techniques, distinguishing between primary and secondary malignancies of the pancreas was diagnostically challenging. The accuracy of diagnosing metastatic lesions to the pancreas using endoscopic ultrasound with fine needle aspiration is around 91%. Distinguishing between primary and secondary lesions is crucial in determining disease management. We present a case of a young man who presented with synchronous pancreatic metastasis from colon adenocarcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Colonic adenocarcinoma with synchronous metastasis to the pancreas: A case report and literature review

et al. 2022

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Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review

et al. 2022

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Metastatic Renal Cell Carcinoma to Pancreas: Case Series and Review of the Literature

et al. 2023

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Metastasis to the pancreas represents a small proportion of all pancreatic malignancies. Among primary tumors that metastasize to the pancreas, renal cell carcinoma (RCC) is one of the most common causes of metastatic pancreatic lesions. We herein report a case series of three patients with pancreatic metastasis from RCC. The first is a 54-year-old male with a history of left nephrectomy for RCC, in whom an isthmic pancreatic mass suggestive of a neuroendocrine lesion was found during oncological follow-up. Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) identified pancreatic metastasis of RCC and the patient was referred for surgery. The second case is a 61-year-old male, hypertensive, diabetic, with left nephrectomy for RCC six years previously, who complained of weight loss and was found with a hyperenhancing mass in the head of the pancreas and a lesion with a similar pattern in the gallbladder. EUS-FNB from the pancreas proved to be a metastatic pancreatic lesion. Cholecystectomy and treatment with tyrosine kinase inhibitors were recommended. The third case is a 68-year-old dialysis patient referred for evaluation of a pancreatic mass, also confirmed by EUS-FNB, who was started on sunitinib treatment. We report a literature summary on epidemiology and clinical features, diagnosis and differential diagnosis and treatment and outcomes in pancreatic metastasis of RCC.

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Diagnosis and Treatment of Metastatic Disease to the Pancreas

Cited by 6 publications

References 22 publications

Colonic adenocarcinoma with synchronous metastasis to the pancreas: A case report and literature review

Colonic adenocarcinoma with synchronous metastasis to the pancreas: A case report and literature review

Resection of isolated pancreatic metastases from pulmonary neoplasia: a systematic review

Metastatic Renal Cell Carcinoma to Pancreas: Case Series and Review of the Literature

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