Diagnosis and treatment of implant-associated infections

Al-Mayahi, Mohamed Abdul-Basit; Vaudaux, Pierre; Deabate, Luca; Lomessy, A.; Suvà, Domizio; Uçkay, İlker

doi:10.1533/9780857097224.1.83

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…Above all, the treatment algorithm chiefly varies by the implant site, type and severity of infection, bone-implant interactions, and condition of the patient. Nonetheless, revision surgeries involved in these approaches often result in severe complications including infections in the surrounding tissues by dissipation of the resident bacteria, tissue loss, and/or defects. , Considering all these reasons, the quest for an improved preventive and treatment strategy for implant associated infections prevails.…”

Section: Pathogenesis Of Orthopedic Implant Failurementioning

confidence: 99%

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

Garg

Matai

Sachdev

2021

ACS Biomater. Sci. Eng.

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An alarming increase in implant failure incidence due to microbial colonization on the administered orthopedic implants has become a horrifying threat to replacement surgeries and related health concerns. In essence, microbial adhesion and its subsequent biofilm formation, antibiotic resistance, and the host immune system's deficiency are the main culprits. An advanced class of biomaterials termed anti-infective hydrogel implant coatings are evolving to subdue these complications. On this account, this review provides an insight into the significance of anti-infective hydrogels for preventing orthopedic implant associated infections to improve the bone healing process. We briefly discuss the clinical course of implant failure, with a prime focus on orthopedic implants. We identify the different anti-infective coating strategies and hence several anti-infective agents which could be incorporated in the hydrogel matrix. The fundamental design criteria to be considered while fabricating anti-infective hydrogels for orthopedic implants will be discussed. We highlight the different hydrogel coatings based on the origin of the polymers involved in light of their antimicrobial efficacy. We summarize the relevant patents reported in the prevention of implant infections, including orthopedics. Finally, the challenges concerning the clinical translation of the aforesaid hydrogels are described, and considerable solutions for improved clinical practice and better future prospects are proposed.

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Section: Pathogenesis Of Orthopedic Implant Failurementioning

confidence: 99%

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

Garg

Matai

Sachdev

2021

ACS Biomater. Sci. Eng.

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“…Current treatment for implant-associated bacterial infection is comprised of prolonged systemic antimicrobial therapy (often lasting weeks to months), revision surgeries, and implant removal. Revision surgeries include local debridement of compromised tissues and, typically, removal of the associated implant followed by re-implantation of a new device after resolution of the infection [ 21 , 25 , 37 ]. Re-implantation of a new device prior to complete clearance of infection can reinitiate the process and add to a prolonged and difficult recovery.…”

Section: Introductionmentioning

confidence: 99%

Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Billings

Anderson

2022

Bioengineering

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As medicine advances and physicians are able to provide patients with innovative solutions, including placement of temporary or permanent medical devices that drastically improve quality of life of the patient, there is the persistent, recurring problem of chronic bacterial infection, including osteomyelitis. Osteomyelitis can manifest as a result of traumatic or contaminated wounds or implant-associated infections. This bacterial infection can persist as a result of inadequate treatment regimens or the presence of biofilm on implanted medical devices. One strategy to mitigate these concerns is the use of implantable medical devices that simultaneously act as local drug delivery devices (DDDs). This classification of device has the potential to prevent or aid in clearing chronic bacterial infection by delivering effective doses of antibiotics to the area of interest and can be engineered to simultaneously aid in tissue regeneration. This review will provide a background on bacterial infection and current therapies as well as current and prospective implantable DDDs, with a particular emphasis on local DDDs to combat bacterial osteomyelitis.

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Reducing plastic in the operating theatre: Towards a more circular economy for medical products and packaging

Ramos

Christensen

Oturai

et al. 2023

Journal of Cleaner Production

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Diagnosis and treatment of implant-associated infections

Cited by 3 publications

References 61 publications

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

Toward Designing of Anti-infective Hydrogels for Orthopedic Implants: From Lab to Clinic

Role of Implantable Drug Delivery Devices with Dual Platform Capabilities in the Prevention and Treatment of Bacterial Osteomyelitis

Reducing plastic in the operating theatre: Towards a more circular economy for medical products and packaging

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