Diagnosis and Assessment of Non-Hodgkin’s Malignant Lymphomas of the Larynx

Abstract

The present paper reports the clinicopathologic features of six cases of non-Hodgkin’s lymphoma of the larynx observed during the last 14 years. After careful clinical staging only 3 patients had isolated laryngeal lymphoma (stage IE). Radiotherapy was administered as initial treatment in all cases. These patients are alive and well after 12,6 and 1 years, respectively. Histologically, all laryngeal lymphomas of this study showed a diffuse pattern of growth. All lymphomas were of follicular center cell origin according to Lukes and Collins (29). Four cases were of low grade malignancy according to Lennert and Mohri (25), or grade I, according to the British (18) classification. The remaining two were of high grade malignancy or grade II. A careful histopathological diagnosis, which may separate other pathological conditions, and an appropriate staging, which may exclude dissemination of disease, are stressed as representing the basis for effective treatment. The applicability of current functional nomenclature is possible also in these extranodal lymphomas.

Lymphoplasmacytic lymphoma of the larynx, soft palate and nasal cavity

“…Radiation is the treatment of choice for localized disease, chemotherapy being reserved for disseminated cases (Ferlito et al, 1981). In spite of apparent cure of the primary disease, all patients when followed up for long enough, developed the same tumour at a distant site (DeSanto and Weiland, 1970).…”

Metachronous Coexistence of Laryngeal Pseudolymphoma and Squamous Cell Carcinoma

“…Gregor [2] reported 5 cases of laryngeal lymphoma and mentioned 40 instances pre viously described in the English medical lit erature. Ferlito et al [3] reported 6 cases, using the current functional nomenclature. 24 cases of malignant lymphoma of the lar ynx were recorded in the Japanese literature during the decades 1960-1980 [4], The natural history of the laryngeal lym phomas appears similar to that of extranodal primary lymphomas of other organs and tis sues.…”

Isolated Non-Hodgkin’s Malignant Lymphoma of the Larynx Presenting as a Large Pedunculated Tumor

“…Chemotherapy is the treatment of choice in patients with disseminated NHL [7,8,11], Our patient had stage IE B-cell-type NHL, indicating radiotherapy as the treatment of choice. However, the patient was diagnosed as having diffuse, large-cell and B-cell-type NHL by histopathological examination, which included immunohistochemical staining, and the case was assessed as intermediate grade according to the pro posed classification with the working formulation.…”