Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Hossain, Mohammad Sorowar; Iqbal, Mohd S.; Khan, Mohiuddin Ahmed; Rabbani, Mohammad Golam; Khatun, Hazera; Munira, Sirajam; Miah, Mamun; Kabir, Amin Lutful; Islam, Naima; Dipta, Tashmim Farhana; Rahman, Farzana; Mottalib, Abdul; Afrose, Salma; Ara, Tasnim; Biswas, Akhil Ranjan; Rahman, Mizanur; Abedin, Akm Mustafa; Rahman, Mahbubur; Yunus, Abm; Niessen, Louis; Sultana, Tanvira Afroze

doi:10.1186/1471-2407-14-438

Cited by 63 publications

(102 citation statements)

References 30 publications

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“…8,13 The finding of leukaemia as the most frequently occurring haematologic malignancy in this study was however similar to the report by Idris et al in Abbottabad, Pakistan 14 and in another study from Bangladesh. 15 The mean age at presentation in this study was 47±17 years. Our patients presented at an older age compared with the patients in a Pakistani study that presented at a younger age of 22.5 years.…”

Section: Discussionmentioning

confidence: 72%

Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis

et al. 2018

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Background Haematologic malignancies cause significant morbidity and mortality and are not uncommon in resource-limited-low income countries. However, the types, pattern of presentation and treatment outcomes vary across regions. We assessed the presentation and overall survival over an 11-year period in adult patients presenting with haematologic cancers in Jos, North Central Nigeria Materials and Methods This retrospective outcome study evaluated patients who presented with haematologic malignancies between 2005–2015 at the Jos University Teaching Hospital (JUTH), Jos. Variables of interest were abstracted through chart reviews. Descriptive statistics were used to evaluate baseline and follow-up parameters. Overall survival (OS) was assessed using Kaplan-Meier method. Results Sixty patients, contributing 25,994 person-days of follow-up were evaluated. The mean age was 43+17 years and 61.7% were males. Thirty-one patients (51.7%) presented with leukemia, 45.0% with lymphoma, and 3.3% with multiple myeloma. Forty-two (70.0%) presented with advanced disease, 5 (5.2%) were HIV positive and 4 (6.7%) had died at the end of follow-up. OS was 84.3% (95% CI: 58.1–94.7). Survival differed by disease group (p=0.01) and having fever at presentation (p=0.02) Conclusion We found long-term OS to be impacted by disease type and status of fever at presentation. Disease-specific Strategies to improve early diagnosis and therapies are needed to ensure optimal outcomes in Nigerian patients.

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Section: Discussionmentioning

confidence: 72%

Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis

et al. 2018

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“…7,8 This was also comparable to studies conducted in India where median age was 30 years and in Bangladesh where median age was 35 years. 9,10 However when mean age was compared with studies conducted in western countries, there was difference in the mean age at presentation. In Western countries, AML generally affects older people with a median age of 65-67 years.…”

Section: Discussionmentioning

confidence: 99%

Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Naeem

Sharif

et al. 2017

TPMJ

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ABSTRACT… Background: Acute myeloid leukemia (AML) is an aggressive haematological malignancy with highest incidence in older adults. AML accounts for approximately 25% of all leukemias in adults in the Western world, and therefore is the most frequent form of leukemia. Patients on chemotherapy and radiotherapy were excluded from the study. Results: Among the 77 patients of Acute Myeloid Leukemia, Acute myeloid leukemia with maturation AML M2 (37.7%) was the most common subtype and the least common was Acute megakaryoblastic leukemia AML M7 (1.3%).Mean age for AML was 28 years (Range 15-75 years). M:F ratio was 1.5:1. Fever was found be the most frequent presenting feature followed by pallor, bleeding and gum hypertrophy in the descending order. More than 50% patients presented with hepatosplenomegaly. Lymphadenopathy was seen in 30% of patients. Mean peripheral blood blast count was 29%. 12 patients (15.5%) presented with pancytopenia. Conclusion: The study showed male predominance in Acute myeloid leukemia with mean age of 28 years and the most common subtype was AML-M2.

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“…NHL attributed approximately 5.1% of all cancer cases and 2.7% of all cancer deaths worldwide (Sharma et al, 2014). Geographically, NHL presence is predominantly observed in North America, Europe, Oceania, and several African countries (Hossain et al, 2014). There are several risk factors for NHL including sex, age, HIV/AIDS, familial aggregation, autoimmune conditions, rheumatoid arthritis, celiac disease, systemic lupus erythematosus (Ekstrom Smedby et al, 2008).…”

Section: Ebv Associated Diseasesmentioning

confidence: 99%

Epstein–Barr Virus: Diseases Linked to Infection and Transformation

Jha

Pei

2016

Front. Microbiol.

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Epstein–Barr virus (EBV) was first discovered in 1964, and was the first known human tumor virus now shown to be associated with a vast number of human diseases. Numerous studies have been conducted to understand infection, propagation, and transformation in various cell types linked to human diseases. However, a comprehensive lens through which virus infection, reactivation and transformation of infected host cells can be visualized is yet to be formally established and will need much further investigation. Several human cell types infected by EBV have been linked to associated diseases. However, whether these are a direct result of EBV infection or indirectly due to contributions by additional infectious agents will need to be fully investigated. Therefore, a thorough examination of infection, reactivation, and cell transformation induced by EBV will provide a more detailed view of its contributions that drive pathogenesis. This undoubtedly expand our knowledge of the biology of EBV infection and the signaling activities of targeted cellular factors dysregulated on infection. Furthermore, these insights may lead to identification of therapeutic targets and agents for clinical interventions. Here, we review the spectrum of EBV-associated diseases, the role of the encoded latent antigens, and the switch to latency or lytic replication which occurs in EBV infected cells. Furthermore, we describe the cellular processes and critical factors which contribute to cell transformation. We also describe the fate of B-cells and epithelial cells after EBV infection and the expected consequences which contribute to establishment of viral-associated pathologies.

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Diagnosed hematological malignancies in Bangladesh - a retrospective analysis of over 5000 cases from 10 specialized hospitals

Cited by 63 publications

References 30 publications

Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis

Presentation and survival in patients with hematologic malignancies in Jos, Nigeria: A retrospective cohort analysis

Acute Myeloid Leukemia; Demographic Features and Frequency of Various Subtypes in Adult Age Group

Epstein–Barr Virus: Diseases Linked to Infection and Transformation

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