ABSTRACT… Background: Acute myeloid leukemia (AML) is an aggressive haematological malignancy with highest incidence in older adults. AML accounts for approximately 25% of all leukemias in adults in the Western world, and therefore is the most frequent form of leukemia. Patients on chemotherapy and radiotherapy were excluded from the study. Results: Among the 77 patients of Acute Myeloid Leukemia, Acute myeloid leukemia with maturation AML M2 (37.7%) was the most common subtype and the least common was Acute megakaryoblastic leukemia AML M7 (1.3%).Mean age for AML was 28 years (Range 15-75 years). M:F ratio was 1.5:1. Fever was found be the most frequent presenting feature followed by pallor, bleeding and gum hypertrophy in the descending order. More than 50% patients presented with hepatosplenomegaly. Lymphadenopathy was seen in 30% of patients. Mean peripheral blood blast count was 29%. 12 patients (15.5%) presented with pancytopenia. Conclusion: The study showed male predominance in Acute myeloid leukemia with mean age of 28 years and the most common subtype was AML-M2.
Background: Acute myeloid leukemia (AML) is an aggressive haematologicalmalignancy with highest incidence in older adults. AML accounts for approximately 25% of allleukemias in adults in the Western world, and therefore is the most frequent form of leukemia.Objective: The aim of study was to analyze the demographic and clinical features and frequencyof various subtypes of acute myeloid leukemia in adult age group in our population. Studydesign: Descriptive Cross sectional survey. Settings: The study was conducted in PathologyDepartment, King Edward Medical University, Lahore. Study Period: Five years September2007 to September 2011. Material and Methods: A five year data of patients diagnosed asacute myeloid leukemia was collected from September 2007 to September 2011 in PathologyDepartment, King Edward Medical University, Lahore. Patients on chemotherapy andradiotherapy were excluded from the study. Results: Among the 77 patients of Acute MyeloidLeukemia, Acute myeloid leukemia with maturation AML M2 (37.7%) was the most commonsubtype and the least common was Acute megakaryoblastic leukemia AML M7 (1.3%).Meanage for AML was 28 years (Range 15-75 years). M:F ratio was 1.5:1. Fever was found be the mostfrequent presenting feature followed by pallor, bleeding and gum hypertrophy in the descendingorder. More than 50% patients presented with hepatosplenomegaly. Lymphadenopathy wasseen in 30% of patients. Mean peripheral blood blast count was 29%. 12 patients (15.5%)presented with pancytopenia. Conclusion: The study showed male predominance in Acutemyeloid leukemia with mean age of 28 years and the most common subtype was AML- M2.
… Background: Dengue fever (DF) is a mosquito-transmitted disease caused by the dengue virus, an enveloped, single stranded RNA virus of flaviridae family. DF is widely distributed in many countries of southeast and southern Asia, Central and South America, and the Western Pacific regions. Dengue fever (DF) has emerged as an epidemic in Pakistan for the past few years. Objectives: To identify the predictive factors for spontaneous bleeding manifestations in Dengue fever. Study Design: Descriptive case series. Settings: Pathology department of King Edward Medical University and affiliated hospitals (Mayo Hospital and Lady Aitchison Hospital). Study Period: Four months of dengue epidemic July-October 2011. Material and Methods: This study included 125 patients with DF. Patients with spontaneous bleeding were identified. Coagulation profile (including platelet count, prothrombin time (PT) and activated partial thromboplastin time (APTT) were recorded in each group (With and without bleeding). Results: Spontaneous bleeding during dengue fever occurred in 53(42.4%) patients. The mean coagulation profile in patients of dengue fever with and without spontaneous bleeding was as follows: platelets (91.28±26.64X109/L versus 112.10±17.12 X 109/L, p<0.05), PT (15.72±2.42 versus 14.47±3.70 seconds, P>0.05), and APTT (41.0±24.00 versus 36.65±4.65 seconds), p<0.05). Conclusions: Frequency of spontaneous bleeding in DF was high. A raised APTT and lower platelets counts was found in patients of dengue fever with bleeding as compared to non bleeders while no difference in PT levels in both groups.
Background: Dengue fever (DF) is a mosquito-transmitted disease caused bythe dengue virus, an enveloped, single stranded RNA virus of flaviridae family. DF is widelydistributed in many countries of southeast and southern Asia, Central and South America, andthe Western Pacific regions. Dengue fever (DF) has emerged as an epidemic in Pakistan forthe past few years. Objectives: To identify the predictive factors for spontaneous bleedingmanifestations in Dengue fever. Study Design: Descriptive case series. Settings: Pathologydepartment of King Edward Medical University and affiliated hospitals (Mayo Hospital andLady Aitchison Hospital). Study Period: Four months of dengue epidemic July-October 2011.Material and Methods: This study included 125 patients with DF. Patients with spontaneousbleeding were identified. Coagulation profile (including platelet count, prothrombin time(PT) and activated partial thromboplastin time (APTT) were recorded in each group (Withand without bleeding). Results: Spontaneous bleeding during dengue fever occurred in53(42.4%) patients. The mean coagulation profile in patients of dengue fever with and withoutspontaneous bleeding was as follows: platelets (91.28±26.64X109/L versus 112.10±17.12 X109/L, p<0.05), PT (15.72±2.42 versus 14.47±3.70 seconds, P>0.05), and APTT (41.0±24.00versus 36.65±4.65 seconds), p<0.05). Conclusions: Frequency of spontaneous bleeding inDF was high. A raised APTT and lower platelets counts was found in patients of dengue feverwith bleeding as compared to non bleeders while no difference in PT levels in both groups.
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