Diabetic Retinopathy in Patients With Diabetic Foot Ulcer: A Systematic Review

Şerban, Dragoş; Παπάνας, Νικόλαος; Dascălu, Ana Maria; Stana, Daniela; Nicolae, Vanessa Andrada; Vancea, G; Badiu, Cristinel Dumitru; Tănăsescu, Denisa; Tudor, Corneliu; Balasescu, Simona Andreea; Stoian, Anca Pantea

doi:10.1177/1534734620982237

Cited by 20 publications

(14 citation statements)

References 42 publications

(101 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It plays a fundamental role in conserving normal ocular function. It is present in high concentrations in the ocular tissue, particularly in the retina and the choroid (17). As demonstrated by PIXE and synchrotron XRF imaging, Zn is found at high levels in the retinal pigment epithelium (RPE)/choroid, photoreceptor inner segments (RIS)/outer limiting membrane (OLM) layer, outer plexiform layer (OPL), and inner nuclear layer (INL) (18,22).…”

Section: Biological Role Of Zn In the Retinamentioning

confidence: 99%

“…At a macroscopic level, obesity and a sedentary lifestyle are well-known risk factors for T2DM, but at a molecular level, oxidative stress is regarded as the primary contributor to the pathogenic processes leading to cellular and vascular damage (16). A high level of glycemia induces specific changes in the retinal microvasculature via the intracellular polyol pathway, increased oxidative stress, and accumulation of advanced glycation end-products (AGEs) (17). The retina is a tissue extremely metabolically active and is susceptible to variations in concentrations of these trace elements.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

et al. 2022

Self Cite

View full text Add to dashboard Cite

Diabetic retinopathy (DR) is a microvascular disorder occurring due to the long-term effects of diabetes, leading to vision-threatening damage to the retina. The human body has an elaborate system for managing and regulating the number of key trace metals circulating in the blood and stored cells. Inadequate zinc (Zn) and concurrent excess of copper (Cu) levels are associated with an increased level of oxidative stress, which may aggravate the microvascular lesions in diabetes mellitus. Several studies have revealed a significantly lower serum Zn concentration and increased Cu levels in DR when compared with diabetic patients without retinopathy and normal controls. These abnormalities are correlated with the duration of diabetes and higher levels of HbA1C. Multiple pathological mechanisms are proposed to explain these changes including hyperzincuria associated with polyuria, glycosuria, and proteinuria in diabetic patients, as well as impaired absorption of Zn at the gastrointestinal level. Increased levels of free Cu ions may be attributed to glycation and the release of Cu ions from the Cu-binding sites of proteins. Zn supplements and selective Cu chelators may be useful to alleviate oxidative stress and prevent DR progression.

show abstract

Section: Biological Role Of Zn In the Retinamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…Mineral calcium and magnesium sulfate waters are confirmed to have ahypoglycemic and lipid-lowering action. They may be used as alternative therapeutic approaches of metabolic syndrome and mild forms of diabetes mellitus, preventing progression to disabling complications, such as diabetic retinopathy of diabetic foot (13,14). The effects on the secretion of the stomach are different, depending on the complexity of the chemical composition: the water from Amara decreases gastric secretion.…”

Section: Pathogenic Background For Crenotherapy Usagementioning

confidence: 99%

Benefits of crenotherapy in digestive tract pathology (Review)

Dumitrescu

Iliescu²,

Mazilu³

et al. 2021

Exp Ther Med

View full text Add to dashboard Cite

Balneotherapy, a branch of physical and rehabilitation medicine using the natural factors of balneal resorts for therapeutical purposes to modulate the symptoms of numerous diseases, represents a non-pharmaceutical therapeutic alternative, easily accepted by patients and used both preventively and curatively. Crenotherapy, a branch of balneotherapy, is the method in which mineral waters are used as a therapeutic internal cure by ingestion. This procedure is performed in spa resorts (where these natural resources exist), and the ingestion of mineral water takes place at the source (spring), in the quantities recommended by the medical rehabilitation physician, according to specific regimens for the condition to be treated. Depending on their physical and chemical composition, the therapeutic mineral waters fall into several categories, having clear indications for certain pathologies. Hypotonic, isotonic, or slightly hypertonic mineral waters are recommended in diseases of the digestive tract and hepatobiliary conditions. Over time, studies have been conducted to determine the effect of these types of treatments, highlighting the complex influence of crenotherapy on the gastrointestinal tract, with favorable results, therefore the use of mineral water intake in various pathologies being recommended. The current review focuses on the existing literature data and refers to the main progress made in understanding the benefit, indications, and crenotherapy procedures in the management of gastrointestinal disorders. Contents1. Introduction 2. Pathogenic background for crenotherapy usage 3. Evidence-based literature data focused on the benefit of crenotherapy for GI (gastrointestinal) tract pathologies 4. Conclusions

show abstract

“…Diabetes mellitus (DM) is an increasingly common metabolic disorder that is a major cause of morbidity and mortality across the globe [ 1 ]. The concept of DM self-care has gained increased attention from clinicians and researchers in the past few decades.…”

Section: Introductionmentioning

confidence: 99%

Correlations between Diabetes Mellitus Self-Care Activities and Glycaemic Control in the Adult Population: A Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

Although it is well known that lifestyle changes can affect plasma glucose levels, there is little formal evidence for the sustained effectiveness of exercise and diet in diabetes mellitus (DM) management. Self-care in DM refers to the real-life application of the knowledge that the patient gained during the education programmes. The goals are to bring about changes in the patient’s behaviour, thus improving glycaemic control. We evaluated the influence of DM self-care activities (SCA) on glycaemic control in a total of 159 patients with DM. Plasma glycated haemoglobin (HbA1c) levels were used to monitor glycaemic control, while SCA were assessed using the standardised Diabetes Self-Management Questionnaire (DSMQ). In our study, 53% of the patients had a HbA1c ≥ 7%. In univariate linear regression models, a statistically significant inverse association was observed between the HbA1c (the dependent variable) and both the DSMQ Dietary Control Score (R2 = 0.037, p = 0.0145) and the DSMQ Sum Score (R2 = 0.06, p = 0.0014). The mean absolute change in the HbA1c% associated with one standard deviation (SD) change in the DSMQ Sum Score, independent of the other significant variables retained in the compacted multivariate regression model, was −0.419% (confidence interval: 95%: from −0.18 to −0.65). Although the impact of the DSMQ Score was modest when compared to the other independent variables in the multivariate model, the findings emphasise the importance of maintaining optimal lifestyle changes to avoid hyperglycaemia and its complications. In conclusion, enhanced self-management of DM is associated with improved glucose control. In patients with chronic diseases such as DM, the role of streamlining SCA encompassing physical activity and proper dietary choices is imperative because of a significantly reduced access to healthcare globally as a result of the COVID-19 pandemic.

show abstract

Diabetic Retinopathy in Patients With Diabetic Foot Ulcer: A Systematic Review

Cited by 20 publications

References 42 publications

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review)

Benefits of crenotherapy in digestive tract pathology (Review)

Correlations between Diabetes Mellitus Self-Care Activities and Glycaemic Control in the Adult Population: A Cross-Sectional Study

Contact Info

Product

Resources

About