Diabetic peripheral neuropathy: resource utilization and burden of illness

Mehra, Maneesha; Merchant, Sanjay; Gupta, Shikha; Potluri, Ravi

doi:10.3111/13696998.2014.928639

Cited by 29 publications

(16 citation statements)

References 29 publications

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“…This is due to differences in the diagnostic criteria employed, types of diabetes, the different methods of patient selection, and the sample size [8,9]. However, it has been estimated that the prevalence of DPN is 8.4% in China [10], 48.1% in Sri Lanka [11], 29.2% in India [12], 56.2% in Yemen [9], 39.5% in Jordan [13], 71.1% in Nigeria [14], 16.6% in Ghana [15], and 29.5% in Ethiopia [16].…”

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confidence: 99%

“…Patients with DPN often suffer from the loss or absence of a protective sensation in the lower extremities leading to balance problems [26], risk of foot ulcerations [22], pain and disrupted sleep patterns [27], cardiovascular morbidity and mortality [19], reduced quality of life [28], and increased cost of treatment [29]. Previous studies have indicated that for those with high-risk diabetic neuropathy, proper management and early screening can minimize the occurrence of ulcers by 60% and amputations by 85% [30].…”

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confidence: 99%

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Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

et al. 2020

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Background: Diabetes mellitus (DM) is a global health care problem that can impose a substantial economic burden. Diabetic peripheral neuropathy (DPN) is a common microvascular complication of DM that increases the potential for morbidity and disability due to ulceration and amputation. Though there is a significant amount of variation in the primary studies on DM regarding the prevalence of DPN in Africa. Hence, this study was aimed to estimate the overall prevalence of DPN in DM patients in Africa. Methods: PubMed, Scopus, Google Scholar, African Journals OnLine, WHO African Library, and the Cochrane Review were systematically searched online to retrieve related articles. The Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines was followed. Heterogeneity across the included studies was evaluated by the inconsistency index (I 2 ). Publication bias was examined by funnel plot and Egger's regression test.The random-effect model was fitted to estimate the pooled prevalence of diabetic peripheral neuropathy among patients in Africa. The meta-analysis was performed using the STATA™ Version 14 software. Results: Twenty-three studies which includes 269,691 participants were included in the meta-analysis. The overall pooled prevalence of diabetic peripheral neuropathy was 46% (95% CI:36.21-55.78%). Based on the subgroup analysis, the highest prevalence of diabetic peripheral neuropathy in DM patients was reported in West Africa at 49.4% (95% CI: 32.74, 66.06). Conclusion: This study revealed that the overall prevalence of diabetic peripheral neuropathy is relatively high in Africa. Hence, DPN needs situation-based interventions and preventive strategies, which are specific to the country. Further meta-analysis is needed to identify associated factors for the occurrence of diabetic peripheral neuropathy.

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Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

et al. 2020

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“…About 50% of the population with T2DM will experience damage to the peripheral nerves. It has caused a significant economic burden to society20. The mechanism of the development of DPN has not yet been fully elucidated.…”

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confidence: 99%

Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation

Chen

et al. 2016

Sci Rep

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Thymoquinone has been reported to exhibit antioxidant and anti-inflammatory effects. Inflammation plays an important role in pathogenesis of diabetic peripheral neuropathy. This study investigated the effects of TQ on proliferation and apoptosis of Schwann cells exposed to high glucose conditions and electrophysiological and morphological changes of the sciatic nerve in a DPN rat model as well as relevant inflammatory mechanism. Cell proliferation and apoptosis of Schwann cells were measured using the Cell Counting Kit-8 and flow cytometry. DPN model was established in streptozotocin-induced diabetic rats. Nerve conduction velocity was measured before and after treatment. Morphologic changes were observed by H&E staining and transmission electron microscopy. COX-2, IL-1β, IL-6, and Caspase-3 expression was investigated by western blotting and Bio-Plex ProTM Assays. Finally, TQ alleviated the inhibition of Schwann cell proliferation and protected against Schwann cell apoptosis. It improved nerve conduction velocity, and alleviated the DPN-induced morphological changes and demyelination of the sciatic nerve. COX-2, IL-1β, IL-6 and Caspase-3 expression in sciatic nerve or isolated cultured Schwann cells, were also decreased by TQ. These results indicate TQ has a protective effect on peripheral nerves in a DPN rat model. The mechanism may be mediated partly by the modulation of the inflammatory reaction.

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“…Cardiovascular disease is the most common complication of diabetes and is a major risk factor for Heart Failure (HF) with preserved ejection fraction (HFpEF). [8][9][10] Cardiovascular complications are the leading cause of death in diabetic patients. 11 Diabetes and Heart Failure (HF) commonly coexist.…”

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confidence: 99%

A Study of Diastolic Dysfunction in Patients of Type-2 Diabetes Mellitus in Rural Population of Western Uttar Pradesh

Kumar¹,

Gautham²,

Singh³

et al. 2017

jebmh

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BACKGROUND Diabetes mellitus is a disease with multisystem involvement. Most common cardiovascular complications of diabetes mellitus is the presence of diabetic cardiomyopathy. Diastolic left ventricular dysfunction may be early sign of diabetic cardiomyopathy, which is easily accessed by echocardiography. The aim of the study is to study the prevalence of left ventricular diastolic dysfunction (LVDD) in asymptomatic, nonhypertensive patients of diabetes mellitus. MATERIALS AND METHODS A study was carried out on 110 diabetic patients. All the patients were subjected to detailed history, physical examination and specific investigations were done to find out the prevalence of diastolic dysfunction. RESULTS Diastolic dysfunction was present in 79.10% of patients. Diastolic dysfunction was present more in female than male (52.88% vs. 47.12%). Grade 1 diastolic dysfunction was the commonest form of diastolic dysfunction followed by grade 2 and grade 3. Diastolic dysfunction was positively correlated with HbA1c level (r=0.191, p=0.046), duration of diabetes (p-value <0.05, r=0.651) and advancing age (r=0.505, p<0.05).

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Diabetic peripheral neuropathy: resource utilization and burden of illness

Cited by 29 publications

References 29 publications

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

Prevalence of diabetic peripheral neuropathy in Africa: a systematic review and meta-analysis

Thymoquinone Alleviates the Experimental Diabetic Peripheral Neuropathy by Modulation of Inflammation

A Study of Diastolic Dysfunction in Patients of Type-2 Diabetes Mellitus in Rural Population of Western Uttar Pradesh

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