Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes

Kim, Eun Sook; Moon, Su‐Jin; Kim, Hun-Sung; Lim, Dong Jun; Cho, Jae Hyoung; Kwon, Hyuk Sang; Ahn, Chul Woo; Yoon, Kun Ho; Kang, Moo Il; Yun, Bong; Son, Ho Young

doi:10.2337/dc10-2222

Cited by 43 publications

(57 citation statements)

References 14 publications

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“…Patients with type 2 diabetes have also demonstrated higher CAVI scores when they also present with diabetic peripheral neuropathy, 36 microvascular conditions, 14 intima-media Data presented as mean AE SD or n (%) of patients. a P < 0.05; continuous variables between the two groups were compared using an unpaired Student's t-test; categorical variables were compared between the two groups using 2 -test.…”

Section: Discussionmentioning

confidence: 99%

Increasing age associated with elevated cardio–ankle vascular index scores in patients with type 2 diabetes mellitus

et al. 2013

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Objective: The study investigated the relationship between arterial stiffness calculated using the cardio-ankle vascular index (CAVI), diagnosis of type 2 diabetes mellitus and type 2 diabetesrelated cardiovascular complications, in patients with type 2 diabetes mellitus (type 2 diabetes) and nondiabetic patients. Methods: A retrospective cross-sectional study was conducted in patients with type 2 diabetes and age-matched nondiabetic patients. CAVI was measured using an automatic vascular screening system. Parameters associated with type 2 diabetes and cardiovascular complications were also measured. Results: A total of 51 patients with type 2 diabetes and 59 nondiabetic patients were enrolled in the study. Significantly higher CAVI scores were observed in patients with type 2 diabetes compared with nondiabetic patients (mean AE SD: 9.55 AE 1.13 versus 8.54 AE 0.94, respectively). Multivariate linear regression analyses demonstrated that age was the only significant factor influencing the CAVI score, in patients with type 2 diabetes. Conclusion: Patients with type 2 diabetes had an increased risk of arterial stiffness, based on the CAVI score, compared with nondiabetic patients; this, in turn, could increase their risk of developing other cardiovascular complications.

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Section: Discussionmentioning

confidence: 99%

Increasing age associated with elevated cardio–ankle vascular index scores in patients with type 2 diabetes mellitus

et al. 2013

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“…Kim et al 39) reported that diabetic peripheral neuropathy was associated with increased CAVI without changes in carotid IMT in type 2 diabetes. Kim et al 40) found that increased CAVI in type 2 diabetes was associated with the presence of arterial plaque, increased IMT, and microvascular complication.…”

Section: (B) Diabetes Mellitusmentioning

confidence: 99%

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Saiki

Sato

Watanabe

et al. 2016

J Atheroscler Thromb

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Measurement of arterial stiffness in routine medical practice is important to assess the progression of arteriosclerosis. So far, many parameters have been proposed to quantitatively represent arterial stiffness. Among these, pulse wave velocity (PWV) has been most frequently applied to clinical medicine because those could be measured simply and non-invasively. PWV had established the usefulness of measuring arterial wall stiffness. However, PWV essentially depends on blood pressure at the time of measurement. Therefore, PWV is not appropriate as a parameter for the evaluation of arterial stiffness, particularly for the studies involving blood pressure changes.On the other hand, stiffness parameter is an index reflecting arterial stiffness without the influence of blood pressure. Recently, this parameter has been applied to develop a new arterial stiffness index called cardio-ankle vascular index (CAVI). Therefore, CAVI does not depend on blood pressure changes during the measurements; CAVI could represent the stiffness of the arterial tree from the origin of the aorta to the ankle.Many clinical studies obtained from CAVI are being accumulated. CAVI showed high value in arteriosclerotic diseases, such as coronary artery diseases, cerebral infarction, and chronic kidney diseases, and also in majority of people with various coronary risk factors. The improvement of those risk factors decreased CAVI. Furthermore, the role of CAVI as a predictor of cardio-vascular events was reported recently.We review the clinical studies on CAVI and discuss the clinical usefulness of CAVI as a candidate surrogate end-point marker for cardiovascular disease.

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“…3 Studies suggest that at the time of diagnosis, the typical patient with type 2 diabetes mellitus have diabetes for at least 4 to 7 years. 4 Among patients with type 2 diabetes mellitus, 25% are believed to have retinopathy, 9% nephropathy and 8% neuropathy at the time of diagnosis. 5 Daruka et al has also reported that in addition to hyperosmolar coma and ketoacidosis, patients with type 2 diabetes may have cardiovascular disease, nephropathy, retinopathy and polyneuropathy.…”

Section: Introductionmentioning

confidence: 99%

Study of serum magnesium levels in diabetes mellitus and its correlation with complications (retinopathy and HbA1c) a cross-sectional study of one year

Saproo

Singh²

2017

Int J Adv Med

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Background: Diabetes mellitus is a heterogeneous group of metabolic disorders characterized by chronic hyperglycemia with disturbance of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both. The aim of this study was to estimate serum magnesium levels in patients with type 2 diabetes mellitus and correlate it with complications of type 2 diabetes mellitus - glycemic control and retinopathy.Methods: A cross-sectional study of 100 patients with type 2 diabetes, attending Government Medical College and associated Hospital, Jammu over a period of one year from 1st November, 2014 to 30th October, 2015. Detailed history including duration of diabetes, treatment mode, symptoms suggestive of retinopathy and associated diseases such as hypertension and ischemic heart disease were obtained, as per the proforma, followed by physical examination.Results: Majority of patients (38%) of type-2 diabetes mellitus were in the age group of 51-60 years. Males constituting 71% with male to female ratio of 2.45:1. Complications were observed in 48 cases, which mainly included retinopathy 60.42% (all non-proliferative). Maximum patients (79%) had abnormal (>6.5%) glycosylated hemoglobin levels ranging from 6.5 to 12%. Patients with diabetic retinopathy had significantly higher prevalence of hypomagnesaemia compared to patients without retinopathy (58.62 % vs 18.31%).Conclusions: Prevalence of hypomagnesaemia in type 2 diabetes was 30% in the present study. The present study illustrates that as the magnesium level decreases in type 2 diabetes mellitus patients, prevalence of retinopathy increases.

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Diabetic Peripheral Neuropathy Is Associated With Increased Arterial Stiffness Without Changes in Carotid Intima–Media Thickness in Type 2 Diabetes

Cited by 43 publications

References 14 publications

Increasing age associated with elevated cardio–ankle vascular index scores in patients with type 2 diabetes mellitus

Increasing age associated with elevated cardio–ankle vascular index scores in patients with type 2 diabetes mellitus

The Role of a Novel Arterial Stiffness Parameter, Cardio-Ankle Vascular Index (CAVI), as a Surrogate Marker for Cardiovascular Diseases

Study of serum magnesium levels in diabetes mellitus and its correlation with complications (retinopathy and HbA1c) a cross-sectional study of one year

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