Diabetic Painful Neuropathy and Restless Legs Syndrome in Diabetes

Kalra, Sanjay; Gupta, Anu

doi:10.1007/s13300-018-0376-6

Cited by 15 publications

(20 citation statements)

References 15 publications

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“…Microalbuminuria was adopted for the diagnosis of diabetic nephropathy. The Restless Syndrome International Study Group Guidelines were used to diagnose restless leg syndrome [8][9]. The criteria include the presence of an unpleasant sensation in the limb with a desire to move, the unpleasant sensation increases with rest and at night and decreases with movement.…”

Section: Methodsmentioning

confidence: 99%

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Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Mirghani¹

2020

Cureus

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Background There is increasing awareness about the association of restless legs syndrome (RLS) with type 2 diabetes. This study assessed RLS and its associations among patients with diabetes. Material and methods This case-control study was conducted among 160 subjects (82 patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan, during the period from June 2018 to September 2019. A structured questionnaire was used to collect demographic factors, diabetic neuropathy, nephropathy, retinopathy, and macrovascular complications. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin (HbA1 c) estimation. The local ethical committee approved the research, and the Statistical Package for Social Sciences (SPSS; IBM Corp., Armonk, NY) was used for data analysis. A P-value of <0.05 was considered significant. Results There were 82 patients with type 2 diabetes and 78 controls matched for age and sex. Restless legs syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with a significant statistical difference, P-<0.05. A direct positive relationship was found between restless legs syndrome and diabetic neuropathy (Wald=5.48, P-value=0.019, 95%CI 1.70-410.76), no relationship was found between RLS, diabetic retinopathy, glycated hemoglobin, sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). Conclusion Restless legs syndrome was prevalent among patients with type 2 diabetes and was more common among patients with diabetic neuropathy, no relationship was found between restless legs syndrome, age, sex, neck circumference, HbA1 c , and retinopathy

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Section: Methodsmentioning

confidence: 99%

“…RLS could be primary or secondary to various disorders, including iron deficiency anemia and polyneuropathy. RLS and painful diabetic neuropathy, although similar, are different entities that pose a great diagnostic challenge [7][8]. The diagnosis is primarily clinical, and there are no diagnostic tests.…”

Section: Introductionmentioning

confidence: 99%

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Mirghani¹

2020

Cureus

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“…International Study Group Guidelines [8,9]were used to diagnose the restless leg syndrome. The criteria include the presence of an unpleasant sensation in the limb with a desire to move, the unpleasant sensation increases with rest and at night and decreases with movement.…”

Section: Study Population and Samplingmentioning

confidence: 99%

“…RLS could be primary or secondary to various disorders including iron deficiency anemia, and polyneuropathy. RLS and painful diabetic neuropathy, although similar, but they are different entities that pose a great diagnostic challenge [7,8]. The diagnosis is primarily clinical, and there are no diagnostic tests, the executive committee of the International Restless Legs Syndrome Study and Workshop group developed and approved four criteria that must be all present in >five times/month [9].…”

Section: Introductionmentioning

confidence: 99%

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

Mirghani¹

2020

Preprint

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Objectives: There is an increasing awareness about the association of the restless leg syndrome (RLS) with type 2 diabetes, the present study assessed RLS and its associations among patients with diabetes. Results: This case-control study conducted among 160 subjects (eighty-two patients with diabetes and 78 controls) attending a diabetic clinic in Omdurman, Sudan during the period from June 2018 to September 2019. A structured questionnaire based on restless syndrome, demographic data, and diabetes complications was used. The neck circumference was measured to assess adiposity, and a blood sample was taken for the glycated hemoglobin estimation.There were 82 patients with type 2 diabetes and 78 controls matched for age and sex, the restless syndrome was higher among patients with diabetes (31.7% vs. 10.3%%) with significant statistical difference, P-<0.05, A direct positive relationship was found between restless leg syndrome and diabetic neuropathy (Wald =5.48, P-value=0.019, 95% CI 1.70-410.76, no relationship was found between RLS, diabetic retinopathy, HbA1 c , sex, and neck circumference, P-values (0.757, 0.804, 0.317, and 0.361 respectively). RLS was prevalent among patients with type 2 diabetes and related to diabetic neuropathy, no relationship was found between restless syndrome, age, sex, neck circumference, HbA1 c , and retinopathy.

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“…Bezüglich der Entstehung der Neuropathien werden unterschiedliche pathogenetische Mechanismen diskutiert, wobei letztlich alle auf zellschädigenden Prozessen durch die bestehende Hyperglykämie beruhen. Hierbei sind u. a. Störungen des Polyol-und Myoinosit-Stoffwechsels, Reduktion der Na/K-ATPase, endoneurale mikrovaskuläre Defizite mit konsekutiver Ischämie, Bildung freier Sauerstoffradikale, Störungen im Stoffwechsel von IGF-1 und des Nerve Growth Factor (NGF), Defekte des axonalen Transports sowie die nichtenzymatische Glykosylierung von wichtigen neuronalen Proteinen zu nennen [4][5][6][7].…”

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Diagnose der diabetischen Neuropathie

Weisser

Lobmann

2020

Diabetes aktuell

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ZUSAMMENFASSUNGDie diabetische Neuropathie ist eine der häufigsten diabetischen Folgeerkrankungen und betrifft mehr als 30 % aller Diabetespatienten. Sie umfasst unterschiedliche Verlaufsformen, wobei die distal-symmetrische sensomotorische Polyneuropathie (DSPN) die häufigste darstellt. Die DSPN ist der wichtigste Risikofaktor für die Entstehung eines diabetischen Fußsyndroms, außerdem gilt sie als unabhängiger Prädiktor für die kardiovaskuläre Morbidität und Mortalität. Dem Hausarzt und dem betreuenden Diabetologen kommt in der Diagnostik eine Schlüsselrolle zu, denn trotz des großen Stellenwerts zur Prävention von Fußläsionen und etwaigen Amputationen, ist die diabetische Neuropathie weiterhin stark unterdiagnostiziert. Alle Screening-Maßnahmen sind mit einfachen Mitteln in der Praxis umsetzbar, darüber hinaus stehen validierte Scores zur Verfügung.

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Diabetic Painful Neuropathy and Restless Legs Syndrome in Diabetes

Cited by 15 publications

References 15 publications

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Restless Legs Syndrome Among Sudanese Patients With Type 2 Diabetes Mellitus: A Case-Control Study

Restless leg syndrome among Sudanese patients with type 2 diabetes mellitus: A case-control study

Diagnose der diabetischen Neuropathie

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