Diabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats

Ohta, Takeshi

doi:10.2174/1876524601104010045

Cited by 3 publications

(2 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, the renal tubular lesions markedly increased with age, with a severe increase in tubular glycogen deposition at 50 and 68 weeks (Figure 6(h)). In addition, urine volume, urine protein, and urine albumin increased with blood glucose at 24 weeks and thereafter, and these changes may be consistent with the development and progression of renal lesions [41, 42]. These renal lesions were also improved by blood glucose control with insulin and thus shown to result from the exposure to high blood glucose [41, 42].…”

Section: Complicationsmentioning

confidence: 95%

The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

Sasase

Ohta

Masuyama

et al. 2013

Journal of Diabetes Research

Self Cite

View full text Add to dashboard Cite

The Spontaneously Diabetic Torii (SDT) rat is an inbred strain of Sprague-Dawley rat and recently is established as a nonobese model of type 2 diabetes (T2D). Male SDT rats show high plasma glucose levels (over 700 mg/dL) by 20 weeks. Male SDT rats show pancreatic islet histopathology, including hemorrhage in pancreatic islets and inflammatory cell infiltration with fibroblasts. Prior to the onset of diabetes, glucose intolerance with hypoinsulinemia is also observed. As a result of chronic severe hyperglycemia, the SDT rats develop profound complications. In eyes, retinopathy, cataract, and neovascular glaucoma are observed. Proliferative retinopathy, especially, resulting from retinal neovascular vessels is a unique characteristic of this model. In kidney, mesangial proliferation and nodular lesion are observed. Both peripheral neuropathy such as decreased nerve conduction velocity and thermal hypoalgesia and autonomic neuropathy such as diabetic diarrhea and voiding dysfunction have been reported. Osteoporosis is another complication characterized in SDT rat. Decreased bone density and low-turnover bone lesions are observed. Taking advantage of these features, SDT rat has been used for evaluating antidiabetic drugs and drugs/gene therapy for diabetic complications. In conclusion, the SDT rat is potentially a useful T2D model for studies on pathogenesis and treatment of diabetic complications in humans.

show abstract

Section: Complicationsmentioning

confidence: 95%

The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

Sasase

Ohta

Masuyama

et al. 2013

Journal of Diabetes Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…It has been reported that the male SDT rats develop diabetes from about 20 weeks of age and that renal lesions accompanied by increases in urine volume and renal function parameters (urinary protein and urinary albumin) are observed from about 24 weeks old (Sasase et al, 2013). The renal lesions and alteration of the renal function parameters observed in the SDT rats are enhanced with the progress of diabetes and the renal lesions are improved by blood glucose control with insulin (Ohta and Sasase, 2011;Ohta et al, 2007). Therefore, the renal lesions observed in the SDT rats are considered to result from exposure to high blood glucose.…”

Section: Introductionmentioning

confidence: 99%

High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats

et al. 2018

View full text Add to dashboard Cite

-Diabetic nephropathy (DN) is one of the complications of diabetes and is now the most common cause of end-stage renal disease. Fructose is a simple carbohydrate that is present in fruits and honey and is used as a sweetener because of its sweet taste. Fructose has been reported to have the potential to progress diabetes and DN in humans even though fructose itself does not increase postprandial plasma glucose levels. In this study, we investigated the effects of high fructose intake on the kidney of the Spontaneously Diabetic Torii (SDT) rats which have renal lesions similar to those in DN patients and compared these with the effects in normal SD rats. This study revealed that a 4-week feeding of the high fructose diet increased urinary excretion of kidney injury makers for tubular injury and accelerated mainly renal tubular and interstitial lesions in the SDT rats but not in normal rats. The progression of the nephropathy in the SDT rats was considered to be related to increased internal uric acid and blood glucose levels due to the high fructose intake. In conclusion, high fructose intake exaggerated the renal lesions in the SDT rats probably due to effects on the tubules and interstitium through metabolic implications for uric acid and glucose.

show abstract

Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat

Ohta¹,

Sasase²,

Gotoh³

et al. 2018

OJAS

Self Cite

View full text Add to dashboard Cite

The number of diabetic patients has recently been increasing all over the world together with lifestyle changes including sedentary life and high-calorie diet intake, and as a result the increase in these suffering from diabetes mellitus has become a global issue. Diabetic animal models play a key role in bettering our understanding of the pathophysiology of diabetes and in developing new therapies for the disease. Diabetes is classified into two types, type 1 and type 2, and type 2 diabetes is chiefly caused by a depletion of insulin secretion in the pancreas and insulin resistance in peripheral tissues. The Goto-Kakizaki (GK) rat and the Spontaneously Diabetic Torii (SDT) rat are genetic non-obese type 2 diabetic models, and the both rats are considered to be suitable models for investigating the etiology of the depletion of insulin secretion and impaired glucose tolerance. In this review, we overviewed the outline of pathophysiological features in GK rats and SDT rats, including biological parameters and pharmacological responses.

show abstract

Diabetic Nephropathy in Spontaneously Diabetic Torii (SDT) Rats

Cited by 3 publications

References 14 publications

The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

The Spontaneously Diabetic Torii Rat: An Animal Model of Nonobese Type 2 Diabetes with Severe Diabetic Complications

High fructose diet feeding accelerates diabetic nephropathy in Spontaneously Diabetic Torii (SDT) rats

Non-Obese Type 2 Diabetic Rat Models-GK Rat and SDT Rat

Contact Info

Product

Resources

About