Diabetic heart and kidney exhibit increased resistance to lipid peroxidation

Antioxidant treatment of experimental diabetic retinopathy in rats with nicanartine

“…The failure to detect an increase of TBARS in the plasma of the untreated diabetic rats is not unprecedented and can be explained by the insufficient specificity of this assay [33][34][35]. Among other reasons for this observation, it is possible that extracellular peroxidation products as measured by TBARS in diabetic rats are only transiently elevated [36].…”

Effect of Potentilla fulgens on lipid peroxidation and antioxidant status in alloxan-induced diabetic mice

“…Th ere is evidence that diabetes alters free radical metabolism in blood and tissues [8][9][10]. Cellular damage by cytotoxic oxygen free radical species leads to complications in diabetes and must, therefore, be rapidly and effi ciently scavenged if cellular damage is to be prevented [11,12]. Degenerative changes in tissues leading to cardiomyopathy, nephropathy and neuropathy are common complications of diabetes mellitus [11].…”

“…Cellular damage by cytotoxic oxygen free radical species leads to complications in diabetes and must, therefore, be rapidly and effi ciently scavenged if cellular damage is to be prevented [11,12]. Degenerative changes in tissues leading to cardiomyopathy, nephropathy and neuropathy are common complications of diabetes mellitus [11]. In addition, signifi cant changes in lipid metabolism and structure also occur in diabetes particularly in patients with vascular complications and atherosclerosis [13][14][15].…”

Oxidative Stress Correlates with Complications Among Diabetic Patients Attending a Diabetic Clinic in Muhimbili National Hospital, Dar es Salaam, Tanzania

“…Oxygen free radicals generated through auto-oxidation of glucose in uncontrolled diabetes, are implicated in the pathogenesis of diabetes mellitus [12]. These oxygen free radicals (OFR), when beyond the ability of the cells antioxidant power, initiate membrane lipid peroxidation resulting in cell damage and tissue injury [13]. Under normal circumstances, the OFRs are cleared by the body's antioxidant system but during diabetes this inherent biological system becomes compromised.…”