Diabetic foot ulcer wound fluid: the effects of pH on DFU bacteria and infection

McArdle, Carla; Lagan, Katie; Spence, Sarah; McDowell, David A.

doi:10.1186/1757-1146-8-s1-a8

Cited by 17 publications

(17 citation statements)

References 3 publications

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“…The pH value is measured and adjusted to improve the stability of the active substance or make it suitable for the area of application. For skin pH ranging from 4-6, 102 the pH of diabetic wounds ranges from 6.5-8, 103 whereas faster healing time for burns occurs below pH 7.32. 104 The pH adjustment of the preparation aims to prevent irritation and changes in the physiological condition of the wound in the healing process.…”

Section: Evaluation Of Film-forming Sprays Phmentioning

confidence: 99%

<p>Film-Forming Sprays for Topical Drug Delivery</p>

Umar¹,

Butarbutar²,

Sriwidodo³

et al. 2020

DDDT

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Film-forming sprays offer many advantages compared to conventional topical preparations because they can provide uniform drug distribution and dose, increased bioavailability, lower incidence of irritation, continuous drug release, and accelerated wound healing through moisture control. Film-forming sprays consist of polymers and excipients that improve the characteristics of preparations and enhance the stability of active substances. Each type of polymer and excipient will produce films with different features. Therefore, the various types of polymers and excipients and their evaluation standards need to be examined for the development of a more optimal form of film-forming spray. The selected literature included research on polymers as film-forming matrices and the application of these sprays for medical purposes or for potential medical use. This article discusses the types and concentrations of polymers and excipients, sprayer types, evaluations, and critical parameters in determining the sprayability and film characteristics. The review concludes that both natural and synthetic polymers that have in situ film or viscoelastic properties can be used to optimise topical drug delivery.

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Section: Evaluation Of Film-forming Sprays Phmentioning

confidence: 99%

<p>Film-Forming Sprays for Topical Drug Delivery</p>

Umar¹,

Butarbutar²,

Sriwidodo³

et al. 2020

DDDT

View full text Add to dashboard Cite

show abstract

“…Such wounds can be infected by various pathogens that are difficult to treat, including fungi from the genera Fusarium or Aspergillus (4,5). The study of the pathogenesis of DFU has focused on poor wound healing and delayed wound healing due to dry gangrene (6,7). Numerous studies have attempted to elucidate the mechanisms underlying refractory DFU and signal transduction pathways in DFU lesions; however these studies have not been successful (8,9).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of the epidermal growth factor on diabetic foot ulcer and the underlying mechanisms

Zhang

Diao

et al. 2018

Exp Ther Med

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The present study aimed to explore the therapeutic effect and underlying mechanism of epidermal growth factor (EGF) on the wound healing of diabetic foot ulcers (DFU). A total of 48 rabbits with DFU were randomly divided into 2 groups, comprising the treatment and control groups. Full-thickness skin (10×10 mm) was excised from the thigh of each rabbit. The wounds in the treatment group were treated with 100 mg/l EGF once a day for 1 month. The control group received no treatment. At 20 days following treatment, new granulation tissues that formed beyond the edge of the wound were collected for subsequent analysis. Tissues from rabbits in the treatment group produced a greater number of fibroblasts, which exhibited a fibroblastic morphology when compared with those in the control group. In the treatment group, a larger number of these fibroblasts were observed as clusters, and there were numerous blood vessels when compared with the control group. The fibroblasts in the control group exhibited an irregular morphology, contained fewer organelles and the surrounding collagenous fibers were sparse. These fibroblasts also demonstrated a disordered arrangement and it was revealed that the wound healed at a slower rate compared with the treatment group. Endogenous EGF mRNA detection revealed that there was a significant difference (P<0.05) in the relative gray value of EGF mRNA between the treatment (103.27±4.27) and control (63.88±4.36) groups. In conclusion, EGF may accelerate the healing of DFU, and exogenous EGF treatment may upregulate the expression of EGF mRNA in newly generated tissues.

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“…Evaluation is a determination process of the individual's responses to the particular treatments in regard to which the outcomes have been accomplished. Several aspects have been acknowledged as outcome measurements such as: HbA1c , high‐density lipoprotein , procalcitonin , potential hydrogen (pH) of wound fluid , wound size and follow‐up care ; collaborating with radiologists in order to evaluate ulcers using imaging techniques ; evaluating the ulcer grade ; and evaluating hyperglycaemia, peripheral artery disease, neuropathy and nutritional status .…”

Section: Resultsmentioning

confidence: 99%

“…Likewise, procalcitonin has been agreed as a biomarker associated with DFU infection signs , due to its sensitivity as well as specificity in evaluating infected DFU . Moreover, pH of wound fluid measurements also help clinical nurses in assessing infection along with predicting DFU healing . Wound size, a predictor of DFU healing, is an important aspect of evaluating DFU intervention as it is expected to get smaller to heal.…”

Section: Resultsmentioning

confidence: 99%

Diabetic foot ulcer care: a concept analysis of the term integrated into nursing practice

Subrata

Phuphaibul

2019

Scandinavian Caring Sciences

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Background Diabetic foot ulcer care demonstrates a beneficial approach to overcoming problems in patients with diabetes. This approach is frequently given but is not always successfully implemented due to its fragmentation amid healthcare providers. What's more, there are a number of different understandings, interchangeable languages and an absence of uniformity overlapping terminologies of meaning for diabetic foot ulcer care. Therefore, analysing the concept of diabetic foot ulcer care is important to provide a wider nursing knowledge, synthesise a greater theoretical model and drive more effective care of diabetic foot ulcer. Objective This article aimed to analyse how the concept of diabetic foot ulcer care is clearly defined in the relevant evidence as it has several implications in nursing practice. Method Walker and Avant's (1995) method of concept analysis was systematically used in this study. Findings Three critical attributes of diabetic foot ulcer care were determined consisting of assessment, intervention and evaluation. Constructed cases are also presented to differentiate the concept of diabetic foot ulcer care from other concepts. This concept analysis results in the critical attributes of diabetic foot ulcer care, defines an operational definition and describes common goals that improve clarity, consistency and understanding of the concept amid healthcare professionals along with researchers. Conclusion Effective implementation of the concept of DFU care into clinical nursing practice may undoubtedly improve patient outcomes and prevent the complexities of DFU in the years to come. Future research needs to be developed for evaluating the current use of this concept.

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Diabetic foot ulcer wound fluid: the effects of pH on DFU bacteria and infection

Cited by 17 publications

References 3 publications

<p>Film-Forming Sprays for Topical Drug Delivery</p>

<p>Film-Forming Sprays for Topical Drug Delivery</p>

Therapeutic effect of the epidermal growth factor on diabetic foot ulcer and the underlying mechanisms

Diabetic foot ulcer care: a concept analysis of the term integrated into nursing practice

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