Diabetes, Wound Healing And Complications: Authors' Reply

Goss, Alastair N.; Sambrook, Paul

doi:10.1111/adj.12117_2

Cited by 3 publications

(3 citation statements)

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“…Саме ці проблеми хворих на ЦД стають складною перепоною при плануванні стоматологічних хірургічних маніпуляцій. Більш того, швидке прогресування запальних процесів, порушення місцевого імунітету, дистрофічні розлади та пригнічення процесів репарації й регенерації стають важливим підґрунтям формування тяжких ускладнень [5,6]. Розуміння патогенетичних механізмів їх формування надасть можливість знизити ризик розвитку ускладнень та розробити патогенетично обґрунтовані методи лікування.…”

Section: вступunclassified

Quantitative Analysis of Proliferative Activity in the Periodontal Tissue of the Rats Following Tooth Extraction Against a Background of Experimental Diabetes Mellitus

Абрамов¹,

Hanchev²

2019

Clin. and experim. pathol.

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Section: вступunclassified

Quantitative Analysis of Proliferative Activity in the Periodontal Tissue of the Rats Following Tooth Extraction Against a Background of Experimental Diabetes Mellitus

Абрамов¹,

Hanchev²

2019

Clin. and experim. pathol.

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“…Завершающий этап резорбтивной фазы местной воспалительной реакции, которому соответствуют 7 сутки постэкстракционного периода, у контрольных крыс характеризуется практически полным восстановление радиологической плотности костной ткани, а на фоне сахарного диабета радиологическая плотность изученных участков снижается, и этот процесс продолжается на 14 сутки. Diabetes mellitus (DM) is regarded today as a metabolic disease, which is considered to be a modulator of endodontic infections [1], is responsible for altering the immune and inflammatory responses, impedes the healing process, contributes to damage of organs and tissues of the body, including tooth pulp and periapical tissues [2,3]. Moreover, numerous clinical observations have shown that DM can not only affect the pathogenesis of dental nosologies, but the bidirectional mutually confounding connection between apical periodontitis, periostitis, gingivitis and the systemic diabetes effects has been also proven.…”

Section: материалы и методыunclassified

“…Moreover, numerous clinical observations have shown that DM can not only affect the pathogenesis of dental nosologies, but the bidirectional mutually confounding connection between apical periodontitis, periostitis, gingivitis and the systemic diabetes effects has been also proven. It has been established that in case of DM patients, on the background of an infectious process in the maxillofacial area were noted to have more evident resorption of the bone and hard tissues of the tooth, sluggish inflammatory processes in the periapical area and periodontal [1][2][3][4][5][6].…”

Section: материалы и методыmentioning

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Specific aspects of the radiographic morphometric and densitometric characteristics of mandible of the rats with experimental diabetes mellitus after tooth extraction

2019

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Diabetes mellitus is regarded today as a metabolic disease, which is considered to be a modulator of endodontic infections, is responsible for altering the immune and inflammatory responses, impedes the healing process, and contributes to damage of organs and tissues of the body, including tooth pulp and periapical tissues.The aim of the work is to study the radiographic characteristics of the dental septum of the alveolar crest of the mandible, crown and root of the low molars of rats with experimental streptozotocin diabetes at different times of the post-extraction period (the 1 st , 7 th and 14 th day). Materials and methods.Studies were conducted on 120 male Wistar rats, 8-10 months old, divided into eight groups of 15 animals each. The experimental diabetes mellitus was modelled in 45 animals by a single administration of streptozotocin interperitoneally (SIGMA Chemical, the USA) at a dose of 50 mg/kg, diluted in 0.5 ml of 0.1 M citrate buffer (pH 4.5) ex tempore, on the 21 st day after its induction the level of fasting glucose was determined (by the glucose oxidise method using standard test strips Test Strip II, glucometer Glucocard, Japan), which was 24.7 ± 2.2 mM/l. The extraction of the first low molar of the right mandible was realised using thiopental anaesthesia (40 mg / kg dose) with additional local infiltration anaesthesia with Ubistesine (3M Deutschland GmbH, Germany).On the 1 st , 7 th , and 14 th day, dates that correspond to the experiment after the extraction of the tooth, the rats were decapitated using thiopental anaesthesia (dose 40 mg/kg).The visiography of the mandible was performed using a computerized 3D CBCT tomograph Panoura 18S Panoramic 3D. With the help of digital image analysis the radiographic density of tissues of the alveolar socket of the removed 1 st molar, crown of the 1 st , 2 nd and 3 rd molars, their root and dental septum of the alveolar crest were determined.The results. Radiological density of the interalveolar and interradicular septa between the 1 st -3 rd molar and the 1 st molar root, which is the most traumatized and loaded rats' tooth, is decreased in the rats with experimental diabetes mellitus. Tooth extraction in the rats with diabetes mellitus results in the increase (not in the decrease as it is observed in control group) of radiological density a day after in the alveolar socket and the adjacent 2 nd and 3 rd molars, that may be caused by significant infiltration related to the secondary alteration. The final stage of the local inflammatory reaction resorptive phase that corresponds to the 7 th day of post-extraction period is characterized by almost complete restoration of the alveolar socket radiological density in the control rats, whereas in the rats with diabetes mellitus radiological density of the studied sites decreases and this process continues on the 14 th day. Conclusions.In the work it was found out that the extraction of a tooth in rats with normal carbohydrate metabolism is accompanied by dynamic changes in radiological density not only in...

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Bone quality analysis of jaw bones in individuals with type 2 diabetes mellitus—post mortem anatomical and microstructural evaluation

et al. 2021

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Diabetes, Wound Healing And Complications: Authors' Reply

Cited by 3 publications

References 3 publications

Quantitative Analysis of Proliferative Activity in the Periodontal Tissue of the Rats Following Tooth Extraction Against a Background of Experimental Diabetes Mellitus

Quantitative Analysis of Proliferative Activity in the Periodontal Tissue of the Rats Following Tooth Extraction Against a Background of Experimental Diabetes Mellitus

Specific aspects of the radiographic morphometric and densitometric characteristics of mandible of the rats with experimental diabetes mellitus after tooth extraction

Bone quality analysis of jaw bones in individuals with type 2 diabetes mellitus—post mortem anatomical and microstructural evaluation

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