Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats

Amawi, Kawther; Almazari, Inas; Alsarhan, Ali; Alhamad, Hamza; Alkhatib, Ahed J

doi:10.1007/s00580-019-02902-5

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…In many reports, the level of HSP70 changes in biofluids along with the severity of several diseases. Changes in the level of HSP70 can be used to diagnose/prognosis in some other diseases, such as diabetes [ 14 , 50 ], cancer [ 13 , 51 ], heart diseases [ 52 , 53 ], and neurodegenerative disease [ 54 , 55 ]. Fig.…”

Section: Resultsmentioning

confidence: 99%

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

Negahdary

Hirata

Sakata

et al. 2023

Analytica Chimica Acta

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Section: Resultsmentioning

confidence: 99%

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

Negahdary

Hirata

Sakata

et al. 2023

Analytica Chimica Acta

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“…16 We also found similar effects on liver induced by anti-oxidants. 17 The impacts of using Ammi visnaga in reducing weight were apparent in significantly lowering the levels of BMI. BMI is a good indicator of health since it determines normal weight, overweight, and obesity.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

AOWMC

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Introduction: Prediabetes status is considered as an important feature in either controlling the development or progression of diabetes. It may pass unnoticed because the symptoms of diabetes are usually not well established. Study objectives: The main objectives of the present study were to explore the efficacy of using Ammi visnagain treating pre-diabetic cases and weight losing. Methods and subjects: A prospective study was conducted to investigate the impact of using Ammi visnaga treatment of pre-diabetes and weight control. The study included 5 patients with pre-diabetes (glucose level was 128±32mg/dl). The age of patients was 42±18.5years. The study included 3 males and 2 females. In general, patients were overweight according to body mass index level was 28±7.8kg/m 2. The patients used the aqueous extract of Ammi visnaga for two months (200 ml daily). Results: At the end of the experiment, the glucose level was significantly reduced (p<0.05) to the level of 88±12.5mg/dl. There was also a significant reduction in the level of BMI from 28±7.8kg/m 2 to 22±6.4kg/m2(p<0.05). Conclusion: The results of the present study showed that Ammi visnaga has the therapeutic potential to control the progression of complete episodes of diabetes by controlling the pre-diabetic status.

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“…We also found that tissue architecture was not well preserved in liver tissue and endometrium tissue in diabetic rat models. 14,15 In previous studies, we showed that white matter is involved in diabetes progression through the up-regulation of iNOS and down-regulation of HSP70. We concluded that brain may have a role in initiating diseases.…”

Section: Deterioration Of Tissue Architecture and Tissue Innervationsmentioning

confidence: 99%

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2021

JNSK

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In this study, we reported our previous observations and perceptions regarding the involvement of neurological components in the malignant tissues. We used to examine different tissues with malignancy, and we observed increased involvement of neurological components as peripheral nerves. At the beginning, no plausible explanation to such phenomenon. Later, we showed in diabetic rat model that white matter was involved in diabetic progression through the up-regulation of inducible nitric oxide synthase (iNOS) and the down-regulation of heat shock protein70 (HSP70). We extended our investigations in other organs in the same model including kidney, liver, testes, and prostate. We found the same phenomenon of the expression of iNOS and HSP70 in the tissues of these organs. We also observed that there was a deterioration of tissue architecture due to diabetic effects. We think that this deterioration may result from the neurological involvement in these tissues. However, because diabetes may result in initiation of some tumors such as endometrium cancer, deterioration of tissue architecture and neurological involvement are becoming more importantly. This study aimed to introduce our hypothesis in this issue "Architecture deterioration as a new medical hypothesis explaining cancer progression". We also reviewed the relevant literature.

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Diabetes upregulates the expression of HSP90 and downregulates HSP70 in the liver of diabetic rats

Cited by 10 publications

References 20 publications

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

Sandwich-like electrochemical aptasensing of heat shock protein 70 kDa (HSP70): Application in diagnosis/prognosis of coronavirus disease 2019 (COVID-19)

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