Diabetes Mellitus Increases Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Virus Patients: A Systematic Review

Abstract

Concurrent DM is associated with increased HCC risk among chronic HCV patients. BMI and steatosis may also increase HCC risk, but the limitations of the current studies do not allow us to draw strong conclusions.

Diabetes, hepatocellular carcinoma, and mortality in hepatitis C‐infected patients: A population‐based cohort study

“…In addition, DM negatively impacts on the prognosis of patients with HCC after curative hepatectomy . Furthermore, a recent systematic review disclosed that DM increases risk of HCC in patients with HCV . Moreover, patients with DM have higher all‐cause mortality compared with those without DM .…”

The association between steatosis and diabetes with hepatocellular carcinoma in non‐genotype 3 chronic hepatitis C patients

“…According to these results, the achievement of SVR most effectively suppressed the risk of HCC in the subgroup of patients without DM and steatosis. Steatosis and DM are associated with the development of HCC . Therefore, the risk of HCC persist in the subgroups of patients with steatosis or DM who obtain SVR.…”

“…There is experimental and clinical evidence supporting the conclusion that HCV-related steatosis is associated with the development of HCC. [6][7][8][9] Moreover, HCV genotype 3 infection is associated with the development of HCC, 10 and in a recent meta-analysis, Dyal et al 11 reported that DM is strongly associated with HCC development among chronic HCV-infected patients. Also, a previous study has reported an association between metabolic steatosis and the development of HCC in chronic hepatitis C (CHC) patients treated with interferon.…”

Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study

“…A majority of studies have also shown that T2DM is a potential risk factor for the presence of HCC in patients with hepatitis C virus infection [12–15]. However, the association between T2DM and HCC in chronic HBV infection patients remains controversial [16–22].…”