Association Between Hepatocellular Carcinoma and Type 2 Diabetes Mellitus in Chinese Hepatitis B Virus Cirrhosis Patients: A Case-Control Study

Abstract

BackgroundWhether the presence of type 2 diabetes mellitus (T2DM) increases the risk of hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) cirrhosis patients is controversial. We conducted a retrospective case-control study to evaluate this issue.Material/MethodsWe considered all patients diagnosed with HBV-related liver cirrhosis at our hospital from July 2011 to June 2014. The case (n=91) and control (n=91) groups were HBV cirrhosis patients with and without T2DM, respectively. They were matched at a ratio of 1: 1 according to the individual age (±2 years) and same sex and Child-Pugh score.ResultsNone of the baseline data were significantly different between the 2 groups. The percentage of HCC was similar between the 2 groups (case versus control group: 34.1% versus 46.2%, P=0.13). In the case group, sex (P=0.002), alkaline phosphatase (P<0.001), γ-glutamine transferase (P=0.001), and sodium (P=0.003) were associated with the risk of HCC. In the control group, platelet (P=0.041), alanine aminotransferase (P=0.034), aspartate aminotransferase (P=0.026), alkaline phosphatase (P<0.001), and γ-glutamine transferase (P<0.001) were associated with the risk of HCC.ConclusionsT2DM may not be a risk factor for the presence of HCC in HBV cirrhosis.

Accumulation of AGO2 Facilitates Tumorigenesis of Human Hepatocellular Carcinoma

“…Hepatocellular carcinoma (HCC), a malignant epithelial liver tumor, is the third leading cause of cancer-associated death globally [1]. The development of HCC is a multistage process involving chronic liver injury, inflammation, hepatocellular degeneration/regeneration, necrosis, and small-cell dysplasia [2].…”

Accumulation of AGO2 facilitates tumor proliferation and metastasis through upregulating Survivin, Vimentin and Snail in human hepatocellular carcinoma

“…Hepatocellular carcinoma (HCC), a malignant epithelial tumor, is the third leading cause of cancerassociated death across the world [1]. The development of HCC is a multistep process and affected by many factors.…”

The Prevalence and Risk Factors of Type II Diabetes Mellitus Among Patients with Hepatitis B Virus: A Descriptive Correlational Study

“…Increased levels of tumor necrosis factor suppress tyrosine phosphorylation in insulin receptors and cause insulin resistance (9). The replication of HBV in pancreatic cells also aggravates insulin dysfunction (9).…”

“…Increased levels of tumor necrosis factor suppress tyrosine phosphorylation in insulin receptors and cause insulin resistance (9). The replication of HBV in pancreatic cells also aggravates insulin dysfunction (9). On the other hand, insulin resistance, steatosis, and cytopathic effects of HBV can accelerate hepatic fibrosis (8).…”

“…In this regard, a study on 3377 individuals showed that the prevalence of hepatitis B surface antigen (HBsAg) seropositivity among diabetic patients was higher than the nondiabetic ones (21.3% vs. 15.53%) (2). Moreover, another study reported that the risk of HBV infection among diabetic patients was 1.5 times higher than nondiabetic individuals (9).…”