Diabetes Mellitus and the Liver

Stone, Bradford G.; Thiel, David H. Van

doi:10.1055/s-2008-1041754

Cited by 100 publications

(46 citation statements)

References 7 publications

(7 reference statements)

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“…The Hispanic Health and Nutrition Examination Survey also reported that abnormal serum ALT levels were statistically significantly more common amongst Mexican Americans suffering from diabetes as compared to their non-diabetic counterparts [24] . Due to the liver playing an important role in the maintenance of glucoregulation, carbohydrate homeostasis and insulin degradation, it seems logical to conclude that the liver's normal functions might be significantly affected as a consequence of glucose intolerance and/or diabetes mellitus [6,[24][25][26] . Hyperlipidemia is frequent amongst subjects who feature abnormal serum activities for certain liver enzymes [11,27] .…”

Section: Implications Of Gender Difference As Regards Associated Riskmentioning

confidence: 99%

A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan

Liu

Tung²,

Liu³

et al. 2005

WJG

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AIM:To explore any gender-related differences in prevalence of and condition-associated factors related to an elevated serum alanine aminotransferase (ALT) level amongst residents of Kinmen, Taiwan. METHODS:A total of 11 898 of a potential 20 112 regional residents aged 30 years or more completed a related questionnaire that was carried out by the Yang-Ming Crusade between 1991 and 1994 inclusively, with blood samples being collected by public nurses. The overall questionnaire response rate was 59.3% (52.4% for males and 66.0% for females). RESULTS:The prevalence of an elevated serum ALT level for this sub-population was found to be 7.2%, the prevalence revealing a statistically significant decrease with increasing population age (P<0.0001). Males exhibited a greater prevalence of elevated serum ALT level than did females (9.4% vs 5.3%, P<0.0001). Using multiple logistic regression analysis, in addition to male gender, a younger age, greater waist circumference, presence of type-2 diabetes and hyperuricemia were the significant factors associated with an elevated serum ALT level for both males and females. Gender-related differences as regards associated factors were also revealed. For males, obesity was significantly related to an elevated serum ALT level (OR = 1.28, 95%CI: 1.00-1.66) but this was not so for females (OR = 1.09, 95%CI: 0.84-1.42). Hypertriglyceridemia (OR = 1.80, 95%CI: 1.36-2.39) and hyperuricemia (OR = 1.61, 95%CI: 1.03-2.52) were significantly related to elevated serum ALT levels only for females. CONCLUSION:Several gender-related differences were noted pertaining to the prevalence of and relationship between obesity, hypertriglyceridemia and hyperuricemia and elevated serum ALT level in the present study.

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Section: Implications Of Gender Difference As Regards Associated Riskmentioning

confidence: 99%

A community-based epidemiological study of elevated serum alanine aminotransferase levels in Kinmen, Taiwan

Liu

Tung²,

Liu³

et al. 2005

WJG

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show abstract

“…The accumulation of glycogen in the liver of the baboon, as well as the lymphohistiocytic portal lesions, suggested diabetes with hepatic involvement (Stone & Van Thiel, 1985). However, further clinical pathological evidence was not available to support a definitive diagnosis of chronic hyperglycaemia and diabetes.…”

Section: Discussionmentioning

confidence: 98%

Enterohepatic Helicobacter species isolated from the ileum, liver and colon of a baboon with pancreatic islet amyloidosis

García

Dewhirst³

et al. 2006

Journal of Medical Microbiology

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“…32,33 It has been reported that up to 50% of type II diabetics have fatty liver. 34,35 In diabetes, however, inadequate pancreatic reserves to overcome tissue insensitivity leads to glucose intolerance. Syndrome X, a metabolic syndrome characterized by the tetrad of type II diabetes mellitus, hyperlipidemia, hypertension, and visceral obesity, has recently been studied in association with fatty liver.…”

Section: Nash Obesity Diabetes and Syndrome Xmentioning

confidence: 99%