Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trøndelag Health Survey

Forsén, Lisa; Meyer, Haakon E; Midthjell, Kristian; Edna, Tom-Harald

doi:10.1007/s001250051248

Cited by 354 publications

(275 citation statements)

References 16 publications

Supporting

Mentioning

248

Contrasting

Unclassified

Order By: Relevance

“…Previous studies have reported an association of non-vertebral fractures with type 2 diabetes (29)(30)(31). Older women with type 2 diabetes have an increased risk for non spine fractures, in particular hip fracture, but the higher risk of falling associated with diabetes may explain this increased risk (32).…”

Section: Discussionmentioning

confidence: 98%

Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study

et al. 2007

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 98%

Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Although there were greater numbers of self-reported fractures, there was no association with BMD-defined osteoporosis. In larger-scale studies, type 1 diabetes increases the risk of fracture, especially in those with microvascular complications [2,14,41] and in females [42,43]. In type 2 diabetes, both lower [44] and higher [1] rates of fracture have been reported, with disease duration and use of insulin increasing the risk [42].…”

Section: Discussionmentioning

confidence: 99%

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

et al. 2006

View full text Add to dashboard Cite

Aims/hypothesis: We assessed the effects of type 1 and type 2 diabetes on bone density and metabolism.Materials and methods: We analysed bone mineral density (BMD) measured at the hip, spine and forearm using dual energy X-ray absorptiometry in 34 patients with type 1 and 194 patients with type 2 diabetes. Patients were from the community-based Fremantle Diabetes Study, and findings for them were compared with those from normal age-and sex-matched control subjects from the local community. Biochemical and hormonal markers of bone metabolism were measured in a subset of 70 patients. Results: After adjusting for age and BMI, there was a lower BMD at total hip (p<0.001) and femoral neck (p=0.012) in type 1 men vs control subjects, but type 1 women and matched controls had similar BMD at each site. There was a higher BMD at total hip (p=0.006), femoral neck (p=0.026) and forearm (p<0.001) in type 2 women vs control subjects, but diabetes status was not associated with BMD in type 2 men after adjustment for age and BMI. Serum oestradiol, BMI, C-terminal telopeptide of collagen type 1 and male sex were consistently and independently associated with BMD at forearm, hip and femoral neck and explained 61, 55 and 50% of the total variance in BMD, respectively, at these sites. Spine BMD was independently associated with BMI and ln(oestradiol). Conclusions/interpretation: Men with type 1 diabetes may be at increased risk of osteoporosis, while type 2 women appear to be protected even after adjusting for BMI. Low serum oestradiol concentrations may predispose to diabetes-associated osteoporosis regardless of sex.

show abstract

“…Type 2 diabetes is more consistently associated with normal or increased BMD [69], whereas, type 1 diabetes is generally associated with decreased BMD [70]. Both types of diabetes are associated with increased risk of fractures [71,72]. Other medical conditions associated with both depression and BMD include epilepsy [73], Crohn's disease [74], rheumatoid arthritis [75], and systemic lupus erythematosus [76].…”

Section: Potential Confounders Comorbid Medical Conditionsmentioning

confidence: 99%

Depression and osteoporosis: epidemiology and potential mediating pathways

2007

View full text Add to dashboard Cite

Introduction-There have been numerous studies examining the association between depression and bone mineral density (BMD), but the underlying nature of this relationship remains unclear. Independent of this association, there is a growing body of evidence that depression impacts the risk for fracture in older adults. This article reviews the current epidemiological evidence regarding comorbidity of depression, low bone mineral density, and fracture.

show abstract

Diabetes mellitus and the incidence of hip fracture: results from the Nord-Trøndelag Health Survey

Cited by 354 publications

References 16 publications

Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study

Associations between the metabolic syndrome and bone health in older men and women: the Rancho Bernardo Study

Bone mineral density and its determinants in diabetes: the Fremantle Diabetes Study

Depression and osteoporosis: epidemiology and potential mediating pathways

Contact Info

Product

Resources

About