Depression and osteoporosis: epidemiology and potential mediating pathways

Mezuk, Briana; Eaton, William W.; Golden, Sherita Hill

doi:10.1007/s00198-007-0449-2

Cited by 106 publications

(101 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, clinical studies showed that depression can also cause a decrease in BMD (12,13,28). In our study, BMD values did not differ in the two groups divided according to depression scores.…”

Section: Discussionsupporting

confidence: 50%

“…In recent years, there has been a dramatic increase in the number of studies investigating chronic rheumatic diseases as a cause of OP (10,11). Depression, decreased physical activity and decreased muscle condition have been shown as risk factors for the development of OP (12)(13)(14). The few studies investigating the relationship between FMS and OP and the risk of OP development in patients with FMS have reported contradictory results (11,15).…”

Section: Introductionmentioning

confidence: 93%

See 1 more Smart Citation

Bone Mineral Density and Depression in Premenopausal Women with Primary Fibromyalgia Syndrome

et al. 2010

View full text Add to dashboard Cite

Objective: Sedentary lifestyle, depression and lack of physical activity may lead to a decrease in bone mineral density (BMD) in patients with fibromyalgia syndrome (FMS). The aim of this study was to evaluate the role of FMS in the development of osteoporosis and the impact of depression on the BMD. Materials and Methods: Fifty premenopausal women with a diagnosis of FMS according to the American College of Rheumatology (ACR) criteria and 40 premenopausal healthy controls were included in the study. A structured form was prepared covering demographic characteristics of the subjects. The severity of pain, disease activity and depression level were evaluated by Visual Analog Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI), respectively. Lumbar spine and left femoral neck BMD values were determined by dual energy X-ray absorptiometry (DEXA). Results: There was no difference between patients and controls according to age, body mass index and duration of education (p>0.05). BMD values in the lumbar vertebrae were significantly lower in the FMS group than in the controls (p<0.05). The BMD score was not different between the patients with a depression score higher or lower than the cut-off point (p>0.05). There were no correlations among BMD, age, and BDI, VAS, and FIQ scores (p>0.05). Conclusion:We found that BMD of the lumbar vertebrae was lower in FMS patients than in the control group. We detected that depression has no significant impact on BMD. (Turk J Rheumatol 2010; 25: 105-9

show abstract

Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 93%

Bone Mineral Density and Depression in Premenopausal Women with Primary Fibromyalgia Syndrome

et al. 2010

View full text Add to dashboard Cite

show abstract

“…This result was similar to the conclusions made by the groups of Itai Bab and Brianna Mezuk (Mezuk et al. 2008; Yirmiya and Bab 2009). Of note, six new studies have been included since these reviews.…”

Section: Discussionmentioning

confidence: 99%

Bone density and depressive disorder: a meta‐analysis

Schweiger

Hüppe

et al. 2016

Brain and Behavior

View full text Add to dashboard Cite

BackgroundThe aim of this study was to evaluate the evidence of low bone mineral density (BMD) in depression. Low BMD is a major risk factor for osteoporotic fractures and frailty.MethodsThe searched database was Pubmed, Meta‐analysis included human studies in men and women fulfilling the following criteria: (1) assessment of BMD in the lumbar spine, the femur or the total hip; (2) comparison of BMD between depressed individuals and the healthy control group; (3) measurement of BMD using dual‐energy X‐ray absorptiometry (DEXA); and (4) data on the mean, standard deviation, or standard error of BMD.ResultsTwenty‐one studies were identified, encompassing 1842 depressed and 17,401 nondepressed individuals. Significant negative composite weighted mean effect sizes were identified for the lumbar spine (d = −0.15, 95%CL −0.22 to −0.08), femur (d = −0.34, 95%CL −0.64 to −0.05), and total hip (d = −0.14, 95%CL −0.23 to −0.05) indicating low BMD in depression. Examining men and women shows low bone density in the lumbar spine and femur in women and low bone density in the hip in men. The differences between men and women with MDD and the comparison group tended to be higher when examined by expert interviewers. Low bone density was found in all age groups.ConclusionsBone mineral density is reduced in patients with depressive disorders. The studies provide little evidence for potential relevant mediating factors.

show abstract

“…Recent studies implicated chronic stress, such as depression in bone loss and osteoporosis, showing there is a link between chronic stress and osteoporosis [11,[31][32][33][34]. Epidemiological studies indicate that depression is an important risk factor for osteoporosis [32][33][34].…”

Section: Relationship Between Chronic Psychological Stress and Osteopmentioning

confidence: 99%

Chronic Psychological Stress as a Risk Factor of Osteoporosis

Chen

Adachi

Hayashi

et al. 2015

J UOEH

View full text Add to dashboard Cite

: Osteoporosis, the most common metabolic skeletal disease, is characterized by decreased bone mass and deteriorated bone quality, leading to increased fracture risk. With the aging of the population, osteoporotic fracture is an important public health issue. Organisms are constantly exposed to various stressful stimuli that affect physiological processes. Recent studies showed that chronic psychological stress is a risk factor for osteoporosis by various signaling pathways. The purpose of this article is to review the recent progress of the association between chronic psychological stress and osteoporosis. Increasing evidence confirms the physiological importance of the central nervous system, especially the hypothalamus, in the regulation of bone metabolism. Both animal and human studies indicate that chronic psychological stress induces a decrease of bone mass and deterioration of bone quality by influencing the hypothalamic-pituitary-adrenocortical (HPA) axis, sympathetic nervous system, and other endocrine, immune factors. Active mastication, proven to be an effective stress-coping behavior, can attenuate stress-induced neuroendocrine responses and ameliorate stress-induced bone loss. Therefore, active mastication may represent a useful approach in preventing and/or treating chronic stress-associated osteoporosis. We also discuss several potential mechanisms involved in the interaction between chronic stress, mastication and osteoporosis. Chronic stress activates the HPA axis and sympathetic nervous system, suppresses the secretion of gonadal hormone and growth hormone, and increases inflammatory cytokines, eventually leading to bone loss by inhibiting bone formation and stimulating bone resorption.

show abstract

Depression and osteoporosis: epidemiology and potential mediating pathways

Cited by 106 publications

References 96 publications

Bone Mineral Density and Depression in Premenopausal Women with Primary Fibromyalgia Syndrome

Bone Mineral Density and Depression in Premenopausal Women with Primary Fibromyalgia Syndrome

Bone density and depressive disorder: a meta‐analysis

Chronic Psychological Stress as a Risk Factor of Osteoporosis

Contact Info

Product

Resources

About