Diabetes mellitus and the incidence of hearing loss: a cohort study

Kim, Min Beom; Zhang, Yiyi; Chang, Yoosoo; Ryu, Seungho; Choi, Yuni; Kwon, Min Jung; Moon, Il Joon; Deal, Jennifer A.; Lin, Frank R.; Güallar, Eliseo; Chung, Eun Chul; Hong, Sung Hwa; Ban, Jae Ho; Shin, Hocheol; Cho, Juhee

doi:10.1093/ije/dyw243

Cited by 95 publications

(86 citation statements)

References 47 publications

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“…Our pooled multivariable-adjusted HR for hearing loss among those with type 2 diabetes as compared with those without type 2 diabetes was lower than previously reported [2, 3]; however, other studies tended not to finely adjust for potentially important confounders, such as BMI. In our analysis, BMI and age were the strongest confounders.…”

Section: Discussioncontrasting

confidence: 88%

“…Most available data are cross-sectional, where hearing loss may have preceded the onset of type 2 diabetes. Longitudinal studies are limited by sample size [1, 2] or short duration of follow-up [3]. Cruickshanks et al found that a high level of HbA 1c , but not the diagnosis of diabetes itself, was associated with a higher risk of incident hearing loss [2].…”

Section: Introductionmentioning

confidence: 99%

“…Cruickshanks et al found that a high level of HbA 1c , but not the diagnosis of diabetes itself, was associated with a higher risk of incident hearing loss [2]. A Korean cohort study found a 36% higher risk for incident hearing loss among those with diabetes [3]. Findings from the few studies investigating the association between the duration of type 2 diabetes and hearing loss have been inconsistent.…”

Section: Introductionmentioning

confidence: 99%

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Type 2 diabetes and the risk of incident hearing loss

et al. 2018

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Aims/hypothesis Type 2 diabetes mellitus has been implicated as a risk factor for hearing loss, with possible mechanisms including microvascular disease, acoustic neuropathy or oxidative stress. A few small studies have examined the longitudinal association between type 2 diabetes and hearing loss, but larger studies are needed. Our objective was to examine whether type 2 diabetes (including diabetes duration) is associated with incident hearing loss in two prospective cohorts: Nurses’ Health Studies (NHS) I and II. Methods We conducted a longitudinal study of 139,909 women to examine the relationship between type 2 diabetes and the risk of self-reported incident hearing loss. A physician-diagnosis of diabetes was ascertained from biennial questionnaires. The primary outcome was hearing loss reported as moderate or worse in severity (categorised as a ‘moderate or severe’ hearing problem, or ‘moderate hearing trouble or deaf’) on questionnaires administered in 2012 in NHS I and 2009 or 2013 in NHS II. Cox proportional hazards regression was used to adjust for potential confounders. Results During >2.4 million person-years of follow-up, 664 cases of moderate or worse hearing loss were reported among those with type 2 diabetes and 10,022 cases among those without type 2 diabetes. Compared with women who did not have type 2 diabetes, those with type 2 diabetes were at higher risk for incident moderate or worse hearing loss (pooled multivariable-adjusted HR 1.16 [95% CI 1.07, 1.27]). Participants who had type 2 diabetes for ≥8 years had a higher risk of moderate or worse hearing loss compared with those without type 2 diabetes (pooled multivariable-adjusted HR 1.24 [95% CI 1.10, 1.40]). Conclusions/interpretation In this large longitudinal study, type 2 diabetes was associated with a modestly higher risk of moderate or worse hearing loss. Furthermore, longer duration diabetes was associated with a higher risk of moderate or worse hearing loss.

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Section: Discussioncontrasting

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Type 2 diabetes and the risk of incident hearing loss

et al. 2018

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“…The correlation between Diabetes Mellitus previous to pregnancy and hearing impairment was found in the studies of Lasagni, et al [12], Lisowska, et al [17], and Dayem, et al [18], who described higher frequency of hearing impairment in patients with Type 1 Diabetes, suggesting that those patients may present a sub clinic hearing disorder caused by the damage of outer hair cells, assessed by optoacoustic emission examination. Kim MB, et al [19] in a multicenter cohort study, highlighted that the characteristic hearing loss in a group of Diabetes Mellitus patients is of sensorineural type and associated with the time of the disease and with the metabolic control of the glycaemia, evaluated by glycated hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

Clin J Obstet Gynecol

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Objective: To evaluate whether the occurrence of maternal pathologies, mainly Diabetes Mellitus and Hypertensive Syndromes in the gestational or pre-gestational period may be related to hearing impairment in postpartum women.Methods: Observational, prospective study including 361 puerperal women who had their deliveries at a reference University Hospital for pregnant women with clinical history of risk. Auditory evaluation was performed by Distortion Product Otoaccoustic Emissions (DPOAE) within 14 days after delivery. Measures of central tendency and absolute and relative frequencies were used to describe the sample and the chi-square test and binary logistic regression to assess the correlation among variables. Signifi cance higher than 95% was observed and the study was approved by the Research Ethics Committee. Results:A total of 361 postpartum women were studied and 7.5% had hearing impairment. The frequency of gestational hypertension was 13.9%, that of gestational diabetes was 8.6% and that of pre-pregnancy diabetes mellitus was 5.8%. The presence of hearing impairment was signifi cantly correlated with the occurrence of pre-pregnancy diabetes mellitus (OR: 4.5 -CI: 1.51-1.47), and maternal age greater than 29 years (OR: 3.72 -1, 58-8.76); A correlation was also found between maternal age and the presence of pre-pregnancy diabetes mellitus (OR: 3.84 -CI: 1.45-10.15). Conclusion:In the population of postpartum women evaluated, having Diabetes Mellitus prior to pregnancy and belonging to the age group older than 29 years increases the chance of having hearing loss.Correlation between the presence of maternal gestational or pre-gestational pathologies and hearing impairment in the puerperal period

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“…There was an increased risk of incident hearing loss in PWD compared with those without diabetes (HR ¼ 1.36 [95% CI, 1.19-1.56]) in a model adjusted for age, sex, study center, noise, body mass, smoking, alcohol, and cardiovascular covariates. 42 Data are also available from the Blue Mountains Hearing study. Prevalence trends were discussed earlier.…”

Section: Diabetes Mellitus and Hearing Loss: Incidence Datamentioning

confidence: 99%

Epidemiology of Diabetes and Hearing Loss

Baiduc

Helzner

2019

Semin Hear

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Hearing loss is a highly prevalent chronic condition. In addition to age, sex, noise exposure, and genetic predisposition, cardiovascular disease and its antecedents may precipitate hearing loss. Of emerging interest is the connection between diabetes and auditory dysfunction. Cross-sectional studies consistently suggest that prevalence of hearing loss is higher in persons with diabetes compared with those without diabetes, especially among younger persons. Furthermore, longitudinal studies have demonstrated higher incidence of hearing loss in persons with diabetes compared to those without diabetes. These findings seem to hold for both type 1 and type 2 diabetes, although considerably more population-based evidence is available for type 2 diabetes. Data on gestational diabetes and hearing outcomes are limited, as are data relating diabetes to otologic sequelae such as fungal infection. Here, we examine evidence from epidemiologic studies of diabetes and hearing loss and consider clinical and laboratory data where population-based data are lacking.

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Diabetes mellitus and the incidence of hearing loss: a cohort study

Abstract: In this large cohort study of young and middle-aged men and women, DM was associated with the development of bilateral hearing loss. DM patients have a moderately increased risk of future hearing loss.

Cited by 95 publications

References 47 publications

Type 2 diabetes and the risk of incident hearing loss

Type 2 diabetes and the risk of incident hearing loss

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Epidemiology of Diabetes and Hearing Loss

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