Epidemiology of Diabetes and Hearing Loss

Baiduc, Rachael R.; Helzner, Elizabeth

doi:10.1055/s-0039-1697643

Cited by 21 publications

(15 citation statements)

References 47 publications

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“…Hearing impairment, both in high-frequency and low-to midfrequency ranges, is more common in people with diabetes than in those without, with stronger associations found in studies of younger people (80). Proposed pathophysiologic mechanisms include the combined contributions of hyperglycemia and oxidative stress to cochlear microangiopathy and auditory neuropathy (81).…”

Section: Sensory Impairmentmentioning

confidence: 99%

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2021

2020

Diabetes Care

198

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The American Diabetes Association (ADA) “Standards of Medical Care in Diabetes” includes the ADA's current clinical practice recommendations and is intended to provide the components of diabetes care, general treatment goals and guidelines, and tools to evaluate quality of care. Members of the ADA Professional Practice Committee, a multidisciplinary expert committee (https://doi.org/10.2337/dc21-SPPC), are responsible for updating the Standards of Care annually, or more frequently as warranted. For a detailed description of ADA standards, statements, and reports, as well as the evidence grading system for ADA's clinical practice recommendations, please refer to the Standards of Care Introduction (https://doi.org/10.2337/dc21-SINT). Readers who wish to comment on the Standards of Care are invited to do so at professional.diabetes.org/SOC.

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Section: Sensory Impairmentmentioning

confidence: 99%

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2021

2020

Diabetes Care

198

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“…Results of studies performed globally have been conflicting with regard to HI and duration of DM, [7,13,17,21] gender, [5,13,22,23] patient age [13,24,25] and type of antidiabetic therapy. [4,12,[26][27][28] Similarly, findings with regard to the relationship between DM-related complications and HI have also been inconclusive, with some studies demonstrating a positive relationship between DM-related neuropathy [12,22] and retinopathy [21] and HI, while others showed none.…”

Section: Researchmentioning

confidence: 99%

The spectrum of hearing abnormalities in patients living with diabetes mellitus

2021

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Background. Diabetes mellitus (DM) causes both micro-and macrovascular complications. The cochlea and auditory nerves are therefore at increased risk from DM-related complications due to microangiopathy, neuropathy or mitochondrial damage. Limited data are available from Africa detailing the association between DM and hearing impairment (HI). Objectives. To describe the prevalence and spectrum of and associations with HI in patients living with DM (PLWD) with and without HIV infection. Methods. This was an analytical cross-sectional study conducted between 1 October and 31 December 2019 at the Edendale Hospital diabetes and audiology clinics in Pietermaritzburg, South Africa. PLWD had an audiological assessment using pure-tone audiometry together with a questionnaire enquiring about tinnitus, vertigo, dizziness and HI. Results. A total of 296 PLWD (89.2% with type 2 DM) were enrolled, of whom 154 (52.0%) had HI. Type 2 PLWD had a significantly higher prevalence of reported symptoms and confirmed audiological HI, which was most often bilateral. The most frequent HI categories were mild to moderate, mild, and moderate to severe (33.8% v. 25.9% v. 23.9%, respectively). Significant associations were noted between dizziness (p=0.045), reported hearing loss (p<0.001) and objective evidence of HI (all categories except mild). HI was significantly associated with age >50 years, DM duration ≤10 years, female gender, hypertension, increased low-density lipoprotein and total cholesterol (TC), lower high-density lipoprotein cholesterol, suboptimal glycaemic control, non-proliferative retinopathy, sensory neuropathy and obesity (p<0.05). Approximately half (48.9%) of PLWD and HIV infection had HI, and they were significantly younger and had higher TC levels than PLWD without HIV (p<0.05). Conclusions. We showed that HI occurs in over half of PLWD, usually within the first 10 years after diagnosis of DM. Symptoms of HI were shown to have positive associations with all HI categories except mild. A high level of vigilance for HI must be maintained in PLWD.

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“…Numerous clinical and experimental studies have shown the effect of diabetes on ABR recordings. These changes include an elevation in the hearing threshold and an increase in waves latency as well as a decrease in the amplitude with changes in waveforms [35,36].…”

Section: Discussionmentioning

confidence: 99%

The Controversial Role of Folic Acid on Diabetic Auditory Neuropathy

Doostkam

Mirkhani

Iravani

et al. 2021

Preprint

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PurposeDiabetic auditory neuropathy(DAN) is a common complication of diabetes that seriously affects the quality of life in patients. In this study, we investigate the role of folic acid in the treatment of DAN in an experimental rat model.MethodsThirty-two Sprague-Dawley rats were equally divided into 4 groups: group 1, normal; group 2, diabetic rats; group 3and 4, rats treated with folic acid (40 and 80 mg/kg, respectively). The tools we used in this study to investigate the effect of folic acid on DAN were auditory brain stem response, stereology methodfor estimation ofthe volume and number ofspiral ganglion,volume of stria vascularis, and spiral ligament, and measurement of homocysteine (HCY), malondealdehyde(MDA) and superoxide dismutase.ResultsOur study showed that folic acid treatment was not significantly effective in improving structural and functional disorders in DAN, despite its effect in reducing HCY and MDA as oxidative biomarkers.ConclusionFolic acid is not effective in relieving morphological and functional disorders in DAN.

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Epidemiology of Diabetes and Hearing Loss

Cited by 21 publications

References 47 publications

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2021

4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2021

The spectrum of hearing abnormalities in patients living with diabetes mellitus

The Controversial Role of Folic Acid on Diabetic Auditory Neuropathy

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