Diabetes mellitus and inflammatory pulpal and periapical disease: a review

Lima, Stella M. F.; Grisi, Daniela Corrêa; Kogawa, Evelyn Mikaela; Franco, Octávio L.; Peixoto, Vanda; Gonçalves-Júnior, J. F.; Arruda, Marcos; Rezende, Taia Maria Berto

doi:10.1111/iej.12072

Cited by 79 publications

(84 citation statements)

References 61 publications

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“…9 Few studies have suggested that DM may serve as a disease modifier of AP in that individuals with diabetes may be more prone to develop the primary disease. However, findings have not yet confirmed that diabetes may influence the response to root canal treatment because treated teeth had no increased prevalence of AP when compared with controls.…”

Section: Introductionmentioning

confidence: 99%

Apical Periodontitis and Endodontic Treatment in Patients with Type II Diabetes Mellitus: Comparative Cross-sectional Survey

Smadi

2017

The Journal of Contemporary Dental Practice

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Aims:The aims of this study were to investigate the prevalence of apical periodontitis (AP) in diabetes mellitus (DM) patients compared with nondiabetic patients and to examine the effect of glycemic control on the prevalence of AP. Materials and methods:Radiographs of a group of DM patients were compared with those of a matched nondiabetic group to identify AP. The diabetic group was subdivided according to the level of glycemic control into two subgroups: A well-controlled DM and a poorly controlled DM. The periapical index score was used to assess the periapical status. All groups were compared in regard to the presence of AP lesions, the number of endodontically treated teeth (ET), and the percentage of failure of endodontically treated teeth (AP/ET ratio). Statistical Package for the Social Sciences (SPSS version 20.0, Chicago, Illinois, USA) was used for all the analyses; p ≤ 0.05 was considered as statistically significant. Results:The prevalence of AP was higher in diabetic group than in the nondiabetic group (13.5 vs 11.9% respectively). Diabetic group had more teeth with endodontic treatment ET compared with nondiabetic group (4.18 vs 1.82% respectively); this difference was statistically significant (p = 0.001) along with higher AP/ET ratio (27.7 vs 19.3 respectively). The poorly controlled DM group had a higher prevalence of AP lesions compared with the well-controlled DM group (18.29 vs 9.21 respectively). This difference was statistically significant (p = 0.001); they also had a higher percentage of ET (5.55 vs 3.13% respectively) and AP/ ET ratio (32.0 vs 21.8% respectively). Conclusion:This survey demonstrates a higher prevalence of AP in DM patients compared with nondiabetic group, with an increased prevalence of persistent chronic AP. Compared with a well-controlled diabetic group, a poor glycemic control may be associated with a higher prevalence of AP and increased rate of endodontic failures. Clinical significance: Counseling diabetic patients, particularly those with poor glycemic control, about the risk of failure of endodontic treatment can be part of planning management, which could include refereeing diabetic patients who need endodontic treatment for consultant care. Apical Periodontitis and Endodontic Treatment in

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Section: Introductionmentioning

confidence: 99%

Apical Periodontitis and Endodontic Treatment in Patients with Type II Diabetes Mellitus: Comparative Cross-sectional Survey

Smadi

2017

The Journal of Contemporary Dental Practice

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“…In sit-uations where healing is compromised, strategies that support the cellular mechanisms of tissue regeneration are required (Garber et al 2009, Lima et al 2013. In sit-uations where healing is compromised, strategies that support the cellular mechanisms of tissue regeneration are required (Garber et al 2009, Lima et al 2013.…”

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confidence: 99%

L‐mimosine increases the production of vascular endothelial growth factor in human tooth slice organ culture model

et al. 2014

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“…As complicações orais em pacientes com diabetes não controlada podem incluir xerostomia, cicatrização deficiente, infecções, aumento da incidência e severidade de cáries, candidíase, gengivite e periodontite (12) . Doenças periodontais severas têm sido associadas a elevados níveis séricos de glicose (13) , especialmente em pacientes não compensados (12) . Demonstra-se que pacientes diabéticos apresentam elevadas perdas de inserção periodontal (9) , ocorrendo inclusive contraindicações em casos nos quais são necessários implantes dentários para promover reabilitação protética (14) .…”

Section: Introductionunclassified