Apical Periodontitis and Endodontic Treatment in Patients with Type II Diabetes Mellitus: Comparative Cross-sectional Survey

Smadi, Leena

doi:10.5005/jp-journals-10024-2046

Cited by 35 publications

(75 citation statements)

References 39 publications

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“…According to the authors, diabetes may serve as a disease modifier of AP in the sense that individuals with diabetes can be more prone to develop primary disease. In agreement with the previous studies, Smadi 35 found that there is a higher prevalence of AP in diabetes mellitus patients compared with that in the nondiabetic group, with an increased prevalence of persistent chronic AP. In comparison with well-controlled diabetes, poor glycemic control may be associated with a higher prevalence of AP and an increased rate of endodontic failures.…”

Section: Continuationsupporting

confidence: 91%

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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Endodontic medicine, which addresses the bidirectional relationship between endodontic infections and systemic diseases, has gained prominence in the field of endodontics. There is much evidence showing that while systemic disease may influence the pathogenesis of endodontic infection, endodontic infection can also cause systemic alterations. These alterations include more severe bone resorption and inflammation in the periapical area as well as enhanced systemic disease symptoms. Similarly, many reports have described the impact of systemic diseases on the tissue responses to dental materials. Conversely, the local use of dental materials may show systemic effects in the form of altered production of biomarkers. Thus, studies to better understand the mechanisms related to those connections are extremely important. In this context, the objective of this review was to analyze and discuss the current literature regarding the connections among these three factors-systemic diseases, endodontic infection, and endodontic dental materials-and determine how these connections may interfere in the systemic health status and the endodontic treatment outcomes, which are represented by periapical wound healing.

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Section: Continuationsupporting

confidence: 91%

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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“…, Arya et al . , Smadi ), and four others did not present results on the frequency of tooth extraction after NSRCT in diabetics and controls (Fouad & Burleson , Doyle et al . , Lin et al .…”

Section: Reviewmentioning

confidence: 94%

Association between diabetes and nonretention of root filled teeth: a systematic review and meta‐analysis

et al. 2018

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Previous studies have found an association between the outcome of root canal treatment (RCT) and diabetic status. This systematic review and meta-analysis aimed to analyse the potential relationship between diabetes and the occurrence of extracted root filled teeth (RFT). The clinical PICO question was as follows: in adult patients with RFT, does the absence or presence of diabetes influence the prevalence of RFT extraction? The key words used in the systematic search were as follows: (Diabetes OR Diabetes Mellitus OR Hyperglycaemia OR Diabetic) AND (Endodontic OR Endodontics OR Endodontic Treatment OR Root Canal Treatment OR Root Canal Preparation OR Root Canal Therapy OR Root Filled Teeth OR Endodontically Treated Teeth) AND (Extraction OR Retention OR Survival OR Success OR Failure OR Outcome). The primary outcome variable was odds ratio (OR) for the frequency of extracted RFT in diabetics and healthy subjects. The method of DerSimonian-Laird with random effects was used to calculate the overall OR. Three hundred titles were identified, and three studies achieved the inclusion criteria. Data from 54 936 root canal treatments, 50 301 in nondiabetic control subjects and 4635 in diabetic patients, were analysed. The calculated overall odds ratio (OR = 2.44; 95% CI = 1.54-3.88; P = 0.0001) implies that diabetics had a significantly higher prevalence of extracted RFT than healthy nondiabetic subjects. The results of available studies indicate a significant relationship between DM and increased frequency of nonretained root filled teeth. Diabetes mellitus should be considered an important preoperative prognostic factor in root canal treatment.

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“…Levels of evidence in humans. An association between apical periodontitis and diabetes was found in seven of these experimental studies with an n value of 455 positive cases (76.47%) [11,33,35,40,41]. However, in one study [34] with an n value of 62 individuals (4.28%), they reported no statistical significance between these two entities and on two studies, they did not report whether or not an association was established, main outcomes are reflected on Table 1 and Table 2.…”

Section: Quality Assessmentmentioning

confidence: 94%

“…Only four articles met the inclusion criteria: 2 studies in animals [38,39] and 2 studies in humans [40,41]. Finally, 21 article were included, 10 studies in animals [22][23][24][25][26][27][28][29]38,39], 10 studies in humans [30][31][32][33][34][35][36][37]40,41] and 1 systematic review [11] (Figure 1).…”

Section: Study Selectionmentioning

confidence: 99%

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

Pérez‐Losada

Estrugo‐Devesa

Castellanos-Cosano

et al. 2020

JCM

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Objective: Investigate if there is an association between apical periodontitis and diabetes mellitus. Material and methods: A bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM). Results: Of the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM. Conclusion: Scientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.

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Apical Periodontitis and Endodontic Treatment in Patients with Type II Diabetes Mellitus: Comparative Cross-sectional Survey

Cited by 35 publications

References 39 publications

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Association between diabetes and nonretention of root filled teeth: a systematic review and meta‐analysis

Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis

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