Diabetes mellitus and accompanying hyperlipidemia are independent risk factors for adhesive capsulitis: a nationwide population-based cohort study (version 2)

Lo, Sui-Foon; Chu, Ssu-Wei; Muo, Chih‐Hsin; Meng, Nai‐Hsin; Chou, Li‐Wei; Huang, Wei‐Cheng; Huang, Chung‐Ming; Sung, Fung‐Chang

doi:10.1007/s00296-013-2847-4

Cited by 40 publications

(49 citation statements)

References 32 publications

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“…3 In diabetes patients, the FS incidence increases to 10.8-29%. [4][5][6] Dyslipidemia 7,8 and high blood pressure 7 seem to increase the risk of this shoulder injury. Hypothyroidism is also a FS risk factor, especially in females.…”

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confidence: 99%

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

Cohen¹,

Leal

Loyola

et al. 2019

Journal Orthopaedic Research

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Frozen shoulder is a condition of loss of active and passive motion as result of inflammatory contracture and fibrosis of the joint capsule. We hypothesize that genetic variants in genes involved in these processes such as genes that play a role in extracellular matrix homeostasis (collagens, glycoproteins, genes involved in TGFβ signaling, and metalloproteinases and its inhibitors) may contribute to the susceptibility to frozen shoulder. We evaluated eighteen SNPs of genes involved in extracellular matrix homeostasis in 186 cases (Nfemales = 114; Nmales = 72) of frozen shoulder and 600 age‐matched controls (Nfemales = 308; Nmales = 292). Multivariate logistic regressions were carried out with age, gender, genetic ancestry, and common comorbidities as covariates. Carriers of the C allele of MMP13 rs2252070 and G/G MMP9 (rs17576 A>G/rs17577 G>A) haplotype may have an increased risk of frozen shoulder (p = 0.002, OR = 1.64, 95%CI = 1.20–2.26, and p = 0.046, OR = 1.40, 95%CI = 1.01–1.95, respectively), especially in females (p = 0.005, OR = 1.91, 95%CI = 1.22–2.99, and p = 0.046, OR = 1.59, 95%CI = 1.01–2.51, respectively). In females, the G allele of MMP9 rs17576 tended to contribute to the susceptibility to the studied disease (p = 0.05, OR = 1.51, 95%CI = 0.97–2.33). In contrast, the presence of the C allele of TGFB1 rs1800470 seems to be associated with a reduced risk (p = 0.04, OR = 0.47, 95%CI = 0.23–0.96) while the GG‐genotype of TGFBR1 rs1590 was associated with increased risk (p = 0.027, OR = 4.11, 95%CI = 1.17–14.38) to frozen shoulder development in males. Thus, we identified genetic variants that were independent risk factors that can aid in the risk assessment of frozen shoulder reinforcing the involvement of MMP and TGFβ signaling in disease development. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res

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mentioning

confidence: 99%

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

Cohen¹,

Leal

Loyola

et al. 2019

Journal Orthopaedic Research

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“…Some articles reported that frozen shoulder is significantly correlated with diabetes mellitus;[32] from some of these articles,[33] we found that frozen shoulder is also associate with hyperlipidemia, especially a nationwide population-based cohort study[32] suggests that hyperlipidemia is an independent risk factor for frozen shoulder. Cumulative detrimental effects of hyperlipidemia on tendon properties were found.…”

Section: Limitation Of Shoulder Movementsmentioning

confidence: 85%

Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

Cui

Lü

et al. 2017

J Res Med Sci

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Frozen shoulder is a chronic condition characterized by pain in the shoulder and restriction of movements in all directions. Some patients are left with long-term limitation of shoulder joint activity with various severities, which results in reduced quality of life. Currently, there is a paucity of literature on the molecular biology of frozen shoulder, and the molecular biological mechanism for periarthritis-induced limitation of shoulder joint movements remains unclear. Research in this field is focused on inflammation and cytokines associated with fibrosis. Repeated investigations confirmed alterations of specified inflammatory mediators and fibrosis-associated cytokines, which might be involved in the pathogenesis of frozen shoulder by causing structural changes of the shoulder joint and eventually the limitation of shoulder movements. The aim of this article is to review studies on molecular biology of frozen shoulder and provide a reference for subsequent research, treatment, and development of new drugs.

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“…Meanwhile, in the present study, the differentially expressed genes were found to be involved in the regulation of lipolysis in adipocytes. Currently, some articles reported that idiopathic adhesive capsulitis is significantly correlated with diabetes mellitus (49) and hyperlipidaemia (50). A nationwide population-based cohort study (49) found that hyperlipidemia is an independent risk factor for idiopathic adhesive capsulitis.…”

Section: Discussionmentioning

confidence: 99%

RNA-sequence analysis of samples from patients with idiopathic adhesive capsulitis

Cui

Zhang

Xiong

et al. 2017

Molecular Medicine Reports

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The present study aimed to investigate idiopathic adhesive capsulitis (frozen shoulder), to gain insights on its pathogenesis, diagnosis and therapeutic targets. Using RNA-sequencing (seq), the present study investigated differentially expressed genes (DEGs) in five samples from five idiopathic adhesive capsulitis patients and two samples from two acromioclavicular dislocation patients, without idiopathic adhesive capsulitis. The DEGs were analyzed using the following tools: Gene Ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathways analysis and protein-protein interaction analysis. A total of 188 DEGs were identified and it was observed that 150 of these were upregulated and 38 were downregulated. It was hypothesized that various nutrient associated proteins may be associated with idiopathic adhesive capsulitis. The Matrix metalloproteinase family of proteins (MMPs), may exhibit a key role in the formation of abnormal collagen cross-links. Overall, the comprehensive and detailed information collected in the present study, regarding idiopathic adhesive capsulitis, may provide a foundation on which in-depth follow-up experiments may be based, aimed at identifying novel strategies for treatment of this disease.

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Diabetes mellitus and accompanying hyperlipidemia are independent risk factors for adhesive capsulitis: a nationwide population-based cohort study (version 2)

Cited by 40 publications

References 32 publications

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

Genetic variants involved in extracellular matrix homeostasis play a role in the susceptibility to frozen shoulder: A case‐control study

Molecular biology of frozen shoulder-induced limitation of shoulder joint movements

RNA-sequence analysis of samples from patients with idiopathic adhesive capsulitis

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