Diabetes mellitus among young adults in Sri Lanka—role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes study

Katulanda, Prasad; Shine, Brian; Katulanda, Gaya; Silva, A.; Asfir, E. L.; Sheriff, Rezvi; Somasundaram, NP; Long, Anna E.; Bingley, Polly J.; McCarthy, Mark I.; Clark, Anne

doi:10.1007/s00125-008-1052-6

Cited by 27 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This is contrary to the findings observed in China and Europe, where compared to north, the frequency of LADA was lower in the southern region [9,18,[39][40][41][42]. Interestingly, lower frequency of LADA 2.6% was noted in an island nation Srilanka near southern coast of India [43]. It needs to be assessed if geographical, climatic and cultural differences within a country or continent directly contribute towards regional discrepancies in the prevalence of LADA by conducting large scale studies.…”

Section: Discussioncontrasting

confidence: 57%

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Kumar¹,

Leiva²

2017

JED

View full text Add to dashboard Cite

Aims: We undertook a study to investigate the prevalence and general characteristics of patients with Latent autoimmune diabetes in adults (LADA).Methods: This was a cross-sectional investigation conducted in the National Capital Region of India. Total of 139 subjects were recruited in the study. All subjects were screened for Glutamic acid decarboxylase autoantibody (GADA). GADA was analysed using ELISA kits with 98% specificity and 92% sensitivity. Results:The prevalence of LADA was 6.5% (6.3% in men and 6.8% in women); 95% Confidence interval (CI): 3.29 -12.0% among adult-onset diabetic patients. Prevalence of LADA seemed to gradually decline with increasing age. LADA (n=9) and DM2 (n=130) patients were compared. LADA patients were younger (p = 0.045), had lower age at onset of diabetes (p = 0.025), waist circumference (p = 0.021). LADA patients had also longer duration of diabetes (p = 0.045). There was no significant difference in BMI between two groups. Conclusions:Our results indicate that LADA represents 6.5 % of cases among adult-onset diabetes in a region of north India. LADA is a prevalent form of adult-onset autoimmune diabetes and not rare. This study shows different phenotypic features of LADA patients compared to DM2 patients. In the developing world, sometimes routine antibody testing may be considered not to be cost-effective. Thus, clinical and phenotypic features of LADA may help clinicians recognize patients for potential antibody screening.

show abstract

Section: Discussioncontrasting

confidence: 57%

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Kumar¹,

Leiva²

2017

JED

View full text Add to dashboard Cite

show abstract

“…If we think that the autoimmune process is the culprit, our scientific efforts should be focused on understanding the aetiology of the process, how it is regulated and the mechanism behind its effect on the target organ, in order to more effectively treat, prevent or cure autoimmune diabetes. We should accept that the autoimmune process comes in different shapes: in all ages [31,37,38], populations [39][40][41][42], phenotypes [31], with different genetic backgrounds [18], in healthy individuals [35], and measured by T cell or B cell activity [9], and can even co-exist with other disease processes, e.g. insulin resistance, leading to what we think is type 2 diabetes [17].…”

Section: Lada Latent Autoimmune Diabetes In Adultsmentioning

confidence: 99%

Latent autoimmune diabetes in adults (LADA) is dead: long live autoimmune diabetes!

Rolandsson

Palmer

2010

Diabetologia

View full text Add to dashboard Cite

“…And the prevalence of GADA-positive diabetes cohort from three largest hospitals in Sri Lanka was 5.4% (n = 54; 95% CI 4.0 -6.8). The prevalence of GADA positivity was much higher among those who were young and had a lower BMI compared with those who were older and more obese [26]. GADA positivity among men and women was 7.…”

Section: Discussionmentioning

confidence: 87%

Glutamic Acid Decarboxylase Autoantibodies Role in Reclassifying Diabetes of Adulthood in Basrah

Mansour¹

2015

Int J Clin Endocrinol Metab

View full text Add to dashboard Cite

Aim: To determine the prevalence and phenotypic characteristics of diabetes subtypes based on glutamic acid decarboxylase autoantibodies (GADA) status in those newly presented diabetic to the Al-Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah, Southern Iraq. Methods :The study design is cross-sectional and includes adult diabetic patients if they are free of insulin treatment for at least 6 months from diagnosis and to be 30 years of age and over from the period of

show abstract

Diabetes mellitus among young adults in Sri Lanka—role of GAD antibodies in classification and treatment: The Sri Lanka Young Diabetes study

Abstract: The prevalence of GADA-positive autoimmune diabetes is low among individuals with young adult-onset diabetes in Sri Lanka. Young-onset diabetic phenotypes appear as a continuum from autoimmune type 1 diabetes to type 2 diabetes.

Cited by 27 publications

References 48 publications

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Latent Autoimmune Diabetes in Adults (LADA): The Prevalent Form of Adult-Onset Autoimmune Diabetes in a Region of India

Latent autoimmune diabetes in adults (LADA) is dead: long live autoimmune diabetes!

Glutamic Acid Decarboxylase Autoantibodies Role in Reclassifying Diabetes of Adulthood in Basrah

Contact Info

Product

Resources

About