Abstract:Aim: To determine the prevalence and phenotypic characteristics of diabetes subtypes based on glutamic acid decarboxylase autoantibodies (GADA) status in those newly presented diabetic to the Al-Faiha Specialized Diabetes, Endocrine and Metabolism Center (FDEMC) in Basrah, Southern Iraq.
Methods :The study design is cross-sectional and includes adult diabetic patients if they are free of insulin treatment for at least 6 months from diagnosis and to be 30 years of age and over from the period of
“…The possible role of CRP in the atherosclerotic process is very complex [5]. CRP facilitates the adhesion and migration of monocytes into the arterial wall and has an inhibitory effect on nitric oxide synthesis, resulting in altered vascular reactivity [6,7]. The hs-CRP assay can accurately detect lower protein concentrations with greater sensitivity than the standard PCR detection assay.…”
The prevalence of metabolic syndrome (MetS) in the young population continues to rise. This study aimed to determine whether adipokines are significant markers in defining MetS in a pediatric population and to assess the effect of a hypocaloric diet and physical activity on serum concentrations of adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP). A prospective study was conducted over a period of 1 year, between January and December 2015, on 66 cases of obesity in children diagnosed at the Louis Turcanu Emergency Hospital for Children in Timisoara, Romania. The patients diagnosed with MetS were put on diet and physical exercise for 3 months. MetS was present in 63.6 % of obese children. There was a significant and positive correlation between MetS and both leptin and hs-CRP and a significant, negative correlation between MetS and adiponectin. After diet and physical activity, 3 patients no longer met the criteria for MetS. Leptin, adiponectin and hs-CRP concentrations statistically improved after a three-month diet and physical activity program. In conclusion, hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in the pediatric population. Diet and physical activity have an impact on metabolic status.
“…The possible role of CRP in the atherosclerotic process is very complex [5]. CRP facilitates the adhesion and migration of monocytes into the arterial wall and has an inhibitory effect on nitric oxide synthesis, resulting in altered vascular reactivity [6,7]. The hs-CRP assay can accurately detect lower protein concentrations with greater sensitivity than the standard PCR detection assay.…”
The prevalence of metabolic syndrome (MetS) in the young population continues to rise. This study aimed to determine whether adipokines are significant markers in defining MetS in a pediatric population and to assess the effect of a hypocaloric diet and physical activity on serum concentrations of adiponectin, leptin, and high-sensitivity C-reactive protein (hs-CRP). A prospective study was conducted over a period of 1 year, between January and December 2015, on 66 cases of obesity in children diagnosed at the Louis Turcanu Emergency Hospital for Children in Timisoara, Romania. The patients diagnosed with MetS were put on diet and physical exercise for 3 months. MetS was present in 63.6 % of obese children. There was a significant and positive correlation between MetS and both leptin and hs-CRP and a significant, negative correlation between MetS and adiponectin. After diet and physical activity, 3 patients no longer met the criteria for MetS. Leptin, adiponectin and hs-CRP concentrations statistically improved after a three-month diet and physical activity program. In conclusion, hs-CRP, leptin and adiponectin can be used as predictors of cardiovascular risk in the pediatric population. Diet and physical activity have an impact on metabolic status.
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