Diabetes mellitus aggravates ranolazine-induced ECG changes in rats

Mashayekhi‐Sardoo, Habibeh; Mohammadpour, Amir Hooshang; Mehri, Soghra; Kamali, Hossein; Sahebkar, Amirhossein; Imenshahidi, Mohsen

doi:10.1007/s10840-021-01016-9

Cited by 2 publications

(4 citation statements)

References 51 publications

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“…Cardiovascular complications are among the main causes of morbidity and mortality in diabetic hypertension [6]. Strict control of blood glucose and blood pressure has been shown to limit these various complications in diabetic hypertensive patients [8].…”

Section: Discussionmentioning

confidence: 99%

“…Several mechanisms such as migration/infiltration of epicardial adipocytes between atrial and ventricular myocytes have been implicated in the creation of electrically inert zones, which confound and accelerate electrical conduction [9][10]. All these mechanisms act in isolation and/or synergistically for atrioventricular electrical and anatomical remodelling [6]. The regulation of heart rate by the electrical activity of E. senegalensis may be due to its blockade of angiotensin II-like receptors, which have been shown to reduce type I collagen fibre synthesis and stimulate type I collagen fibre degradation.…”

Section: Discussionmentioning

confidence: 99%

“…These diseases have become a major health threat in the modern world, affecting millions of people and causing an economic downturn [5]. Diabetes mellitus (DM) is linked to an increased incidence of cardiovascular diseases such as coronary heart disease, heart failure, myocardial infarction (MI) and angina, which in turn lead to disability and death [6]. Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults, with a current prevalence of 2-4% [7].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, a reliable, easyto-apply tool for early detection of AF is crucial in clinical practice, especially in hypertensive and diabetic patients [8]. The electrocardiogram (ECG) is a practical, reliable and rapid tool that has been widely used to screen for cardiovascular disease, specifically cardiac arrhythmias [6]. Hypertension, hyperglycaemia, but also hypercholesterolaemia are well known risk factors strongly implicated in the occurrence of cardiovascular events [9].…”

Section: Introductionmentioning

confidence: 99%

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Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

Bidingha

Bilanda

Donfack

et al. 2022

JOCAMR

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Background and Aim: Cardiovascular complications are the main cause of morbidity and mortality in hypertensive diabetic patients. They develop due to microvasculopathy, myocardial hypertrophy and cardiac fibrosis. In the present study, the activity of aqueous extract of Erythrina senegalensis on cardiovascular complications in diabetic hypertensive rats was evaluated. Experimental Procedure: The model of hypertensive diabetic rats was obtained by daily oral administration of sucrose (15%) and 40° ethanol at doses of 1.5 and 5 g/kg respectively for six weeks, followed by an intravenous injection of streptozotocin (35 mg/kg). After four weeks of complications, the diabetic hypertensive rats were divided into six groups of 5 animals each, and received the different treatments for four weeks where blood glucose level was taken weekly. At the end of the treatments, the animals were anaesthetised and the arterial pressures and electrocardiograph were recorded by the direct method. Then the aorta and heart were removed for biochemical calorimetric analysis and histological evaluation. Results and Conclusion: In the diabetic hypertensive animals the results showed chronic hyperglycaemia associated with high blood pressure. On the electrocardiogram there was a cardiac arrhythmia manifested by a significant decrease in the duration of the PR, QRS, RR, QTc segments, ST interval, P, QRS and T waves, a decrease in the amplitude of the QRS and T waves. There was a significant increase in total cholesterol, triglyceride atherogenic index and a decrease in HDL-cholesterol with a change in the cardiac ionogram and oxidative status in the aorta and heart. The different treatments improved these parameters and cardiovascular function. These results suggest that the extract of E. senegalensis by the presence of several bioactive compounds would possess cardioprotective, hypoglycaemic, hypotensive and antioxidant properties.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

Bidingha

Bilanda

Donfack

et al. 2022

JOCAMR

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Enhancement of Physicochemical and Pharmacokinetic Characteristics of Ranolazine drug substance using Cocrystalization Technique

Vyas,

Jigar,

Jacob

2024

RJPT

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Biopharmaceutical Classification System II drug, Ranolazine exhibits pH-dependent solubility and thus shows variable absorption along the gastrointestinal tract. Due to poor aqueous solubility particularly in basic pH, an attempt has been made to improve solubility through the cocrystallization technique. Cocrystals of Ranolazine with Nicotinamide have been synthesized at different molar ratios (1:1, 1:2, 1:3 2:1, and 3:1) through solvent-assisted grinding, slurry preparation, and solvent evaporation method and subsequently characterized by different analytical methodologies. Conformational characterization studies have been performed using techniques like melting point analysis, powder X-ray diffraction, and differential scanning calorimetry. Saturation solubility of Ranolazine alone along with cocrystals prepared in different molar ratios was conducted in water and buffers of different pH (1.2, 4.5, and 6.8) to establish enhancement in solubility. Ranolazine: Nicotinamide 1:2 cocrystals were found to be stable in accelerated and long-term stability conditions. In-vivo study performed in rats to demonstrate enhanced bioavailability. Ranolazine cocrystals with Nicotinamide were shown to have enhanced solubility in basic pH and improved peak plasma concentration, the area under the curve, and relative bioavailability by 2-folds.

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Diabetes mellitus aggravates ranolazine-induced ECG changes in rats

Cited by 2 publications

References 51 publications

Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

Effects of Erythrina senegalensis (Fabaceae) Stem Bark Aqueous Extract in Cardiovascular Complications on Hypertensive Diabetic Rat

Enhancement of Physicochemical and Pharmacokinetic Characteristics of Ranolazine drug substance using Cocrystalization Technique

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