Diabetes Mellitus, a New Risk Factor for Lumbar Spinal Stenosis: A Case–Control Study

Abstract

OBJECTIVESThis study aimed to determine the prevalence of diabetes mellitus in patients with spinal stenosis and lumbar vertebral disk degeneration, and the correlation of diabetes with these diseases.STUDY DESIGNThis is a cross-sectional study.METHODSThis case–control study was performed during 2012–2014 with 110 patients suffering from lumbar spinal stenosis and 110 patients with lumbar disk herniation, who were diagnosed using clinical and radiological evidences. Additionally, 110 participants who were referred to the clinic and did not show clinical signs of degenerative diseases of the lumbar spine entered the study as a control group. Demographic data and medical histories of the patients were collected using checklists.RESULTSA total of 50 patients (15.2%) were diagnosed with diabetes, which comprised 32 (29.1%) in the stenosis group, 7 (6.4%) in the lumbar disk herniation group, and 11 (10%) in the control group. The prevalence of diabetes in women with spinal stenosis and women with lumbar disk herniation was 35.9% and 10.3%, respectively, whereas prevalence of diabetes in women was 10.9% in the control group. This difference was statistically significant in the spinal stenosis group in comparison with the controls (P < 0.0001). Conversely, no significant difference was found in men.CONCLUSIONSThere is an association between diabetes and lumbar spinal stenosis. Diabetes mellitus may be a predisposing factor for the development of lumbar spinal stenosis.

Quantitative Evaluation of Vertebral Microvascular Permeability and Fat Fraction in Alloxan-induced Diabetic Rabbits

“…(2,3). Diabetes mellitus is considered a risk factor for the development of lumbar spinal stenosis (4,5). Numerous studies have shown that vertebral body and accessory lesions, including osteoporosis (6), compression fractures of lumbar vertebrae (7), benign and malignant tumors (8,9), and hematologic disease (10), are closely related to the permeability of bone marrow and vertebral fat deposition.…”

Factors associated with lumbar spinal stenosis in a large-scale, population-based cohort: The Wakayama Spine Study

“…The prevalence of lifestyle diseases, such as hypertension, DM, and PAD, has been reported to be high among individuals with LSS [ 6 , 8 , 26 , 27 ]. The prevalence of DM is particularly high (13.6–29.1%) and has been considered a risk factor for LSS.…”

“…However, many healthy individuals also demonstrate similar age-related changes, including similar degrees of radiographic LSS (rLSS) to that in patients with sLSS, but remain asymptomatic [ 5 ]. Recent studies have shown that lifestyle-related diseases such as diabetes mellitus (DM), peripheral artery disease (PAD), and heart disease, are frequently associated with sLSS [ 6 – 8 ]. However, the prevalence of medical comorbidities also increases with age, and to our knowledge, most previous studies were case-control studies with selection bias.…”

The Difference in Gender Affects the Pathogenesis of Ligamentum Flavum Hypertrophy

“…The exclusion criteria were as follows: (i) prior spine surgery; (ii) systemic inflam-matory disease; (iii) neurologic disorder; (iv) acute trauma, neoplasm, or infection; (v) spinal deformities or spondylolisthesis (over Meyerding grade II); and (vi) diabetes. The rationale for the exclusion of patients with diabetes was the association between LF thickness and diabetes reported in previous studies 10,11) . The equipment comprised a spine coil with a GE Signa HDx 1.5 T (GE Healthcare, Milwaukee, WI, USA).…”