Diabetes Mellitus: A Local and Global Public Health Emergency!

Al-Lawati, Jawad

doi:10.5001/omj.2017.34

Cited by 146 publications

(114 citation statements)

References 9 publications

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“…Diabetes mellitus (DM) poses a serious public health issue [1]. As of 2017, there were 425 million diagnosed diabetics worldwide, and this number may increase up to 629 million in 2045 according to an International Diabetes Federation report [2].…”

Section: Introductionmentioning

confidence: 99%

Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats

et al. 2019

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Cardiovascular diseases are one of the most common complications of type 2 diabetes. They are considered the leading cause of death among diabetics. One of the mechanisms underlying diabetic cardiovascular complications is oxidative stress. Many phenolic acids are regarded as antioxidants. The aim of the study was to investigate the effect of rosmarinic acid (RA) and sinapic acid (SA) on oxidative stress parameters in the cardiac tissue and serum of type 2 diabetic female rats. Additionally, the effect of these compounds on glucose homeostasis and lipid profile in the serum was evaluated. Type 2 diabetes was induced with high-fat diet and streptozotocin. RA at the doses of 10 and 50 mg/kg and SA at the doses of 5 and 25 mg/kg were administrated orally for 28 days. Untreated diabetic rats exhibited unfavorable changes in glucose metabolism and lipid profile. Changes in the enzymatic and non-enzymatic markers indicated the onset of oxidative stress in these animals. The results showed that the higher doses of the tested phenolic acids—50 mg/kg of RA and 25 mg/kg of SA—revealed beneficial effects on oxidative stress in the cardiac tissue of diabetic rats.

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Section: Introductionmentioning

confidence: 99%

Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats

et al. 2019

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“…Diabetes is one of the most important current public health problems worldwide [12]. It is associated with obesity, aging, and impaired cognitive performance, and is characterized by hyperglycemia and hyperinsulinemia, which reflect glucose intolerance and insulin resistance [13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Silk Peptide on Obesity, Hyperglycemia, and Skeletal Muscle Regeneration in High-Fat Diet-Fed Mice

Lee

Jin

Chei

et al. 2020

Cells

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Obesity is associated with excess body fat accumulation that can cause hyperglycemia and reduce skeletal muscle function and strength, which characterize the development of sarcopenic obesity. In this study, we aimed to determine the mechanism whereby acid-hydrolyzed silk peptide (SP) prevents high-fat diet (HFD)-induced obesity and whether it regulates glucose uptake and muscle differentiation using in vivo and in vitro approaches. Our findings demonstrate that SP inhibits body mass gain and the expression of adipogenic transcription factors in visceral adipose tissue (VAT). SP also had an anti-diabetic effect in VAT and skeletal muscle because it upregulated glucose transporter type 4 (GLUT4) and uncoupling protein 3 (UCP3) expression. Furthermore, SP reduced ubiquitin proteasome and promoted myoblast determination protein 1 (MyoD)/myogenic factor 4 (myogenin) expression, implying that it may have potential for the treatment of obesity-induced hyperglycemia and obesity-associated sarcopenia.

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“…Diabetic cardiomyopathy (DCM), characterized by myocardial disorder as well as systolic and diastolic dysfunction, has become a major public health issue. The presence of DCM is independent of recognized causes such as ischemic heart disorders or hypertension, but it can eventually result in heart failure and death [1]. Oxidative stress, chronic inflammation and high glucose intake are main risk factors for DCM [1].…”

Section: Introductionmentioning

confidence: 99%

“…The presence of DCM is independent of recognized causes such as ischemic heart disorders or hypertension, but it can eventually result in heart failure and death [1]. Oxidative stress, chronic inflammation and high glucose intake are main risk factors for DCM [1]. Hyperglycemia is indeed a major mediator of cardiomyopathy through induction of a series of secondary transducers such as reactive oxygen species (ROS) [1].…”

Section: Introductionmentioning

confidence: 99%

“…Oxidative stress, chronic inflammation and high glucose intake are main risk factors for DCM [1]. Hyperglycemia is indeed a major mediator of cardiomyopathy through induction of a series of secondary transducers such as reactive oxygen species (ROS) [1]. Unwarranted ROS cause damage to genes and proteins that ultimately lead to cell apoptosis [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

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Astaxanthin protects against diabetic cardiomyopathy via activation of Akt pathway in H9c2 cells

Hu¹,

Shen²,

Li³

et al. 2019

Trop. J. Pharm Res

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Purpose: To investigate the cardioprotective action of astaxanthin, and to elucidate its underlying mechanism of action in H9c2 cells. Methods: Cell viability was determined by MTT assay. Intracellular reactive oxygen species (ROS) were evaluated using 2, 7-dichlorodihydro-fluorescein diacetate (H2DCFDA) staining. Cell apoptosis were assessed by determining caspase activities using colorimetric assay. The apoptotic cells were labelled with annexin V/PI staining and quantified by flow cytometry. Involvement of Akt signaling pathway was verified using western blot. Results: The results revealed that astaxanthin (5 and 10 μM) dose-dependently reversed high glucoseinduced cell viability loss in H9c2 cells (p < 0.01 and p < 0.001, respectively). Astaxanthin inhibited intracellular ROS production, decreased caspase 3 and caspase 9 activities in high glucose-challenged H9c2 cells in a concentration-related manner (p < 0.05). Besides, astaxanthin markedly inhibited the number of apoptotic H9c2 cells induced by high glucose. Furthermore, western blot analysis demonstrated that astaxanthin upregulated the activation of Akt signaling. Conclusion: Astaxanthin may protect high glucose induced diabetic cardiomyopathy via activation of Akt pathway, and thus deserves further investigation as a cardioprotective agent.

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Diabetes Mellitus: A Local and Global Public Health Emergency!

Cited by 146 publications

References 9 publications

Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats

Effect of Rosmarinic Acid and Sinapic Acid on Oxidative Stress Parameters in the Cardiac Tissue and Serum of Type 2 Diabetic Female Rats

Effect of Dietary Silk Peptide on Obesity, Hyperglycemia, and Skeletal Muscle Regeneration in High-Fat Diet-Fed Mice

Astaxanthin protects against diabetic cardiomyopathy via activation of Akt pathway in H9c2 cells

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