Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients

León-Abarca, Juan Alonso; Portmann-Baracco, Arianna; Bryce-Alberti, Mayte; Ruiz-Sánchez, Carlos; Accinelli, Roberto A.; Soliz, Jorge; Gonzáles, Gustavo F.

doi:10.1371/journal.pone.0255144

Cited by 22 publications

(17 citation statements)

References 68 publications

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“…It has been reported that the prognosis is worse in patients with type 2 DM who have metabolic syndrome (MetS) components at the onset of the COVID-19 infection. 16 …”

Section: Discussionmentioning

confidence: 99%

COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience

Böyük

Akın²,

Aladağ³

et al. 2022

Journal of Investigative Medicine

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COVID-19 infection is known to increase mortality in patients with diabetes. We aim to demonstrate the differences in disease course and clinical outcomes of patients with COVID-19 regarding the presence of impaired fasting glucose, pre-existing diabetes mellitus (DM) or new-onset DM. 236 patients with positive reverse transcription-PCR tests for SARS-CoV-2 were included in this single-center, retrospective observational study between March 2020 and May 2021. Laboratory results, comorbidities, medications and imaging findings were noted. Logistic regression was used to estimate associated factors for admission to the intensive care unit (ICU). 43 patients with normal glucose, 53 with impaired fasting glucose, 60 with newly diagnosed DM, and 80 with pre-existing DM were classified. Patients with pre-existing DM had higher fasting glucose and glycated hemoglobin than the other groups (p<0.001 for all). Patients with newly diagnosed DM were more likely to need dexamethasone 6 mg (p=0.001). In both newly diagnosed diabetes and impaired fasting glucose groups, 250 mg methylprednisolone was needed at higher rates (p=0.002). Newly diagnosed DM had higher rates of intubation (21.6%) and more mortality (20.0%) (p=0.045 and p=0.028, respectively). Mortality and hospitalization in the ICU were lower in the group receiving antidiabetic treatment. The risk of ICU attendance was higher in patients with impaired fasting glucose (HR=1.71, 95% CI: 0.48 to 6.08) and newly diagnosed DM (HR=1.88, 95% CI: 0.57 to 6.17), compared with pre-existing DM and non-diabetics. Newly diagnosed DM and impaired fasting glucose are associated with increased mortality and intubation in inpatients with COVID-19.

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“…It has been reported that the prognosis is worse in patients with type 2 DM who have metabolic syndrome (MetS) components at the onset of the COVID-19 infection. 16 …”

Section: Discussionmentioning

confidence: 99%

COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience

Böyük

Akın²,

Aladağ³

et al. 2022

Journal of Investigative Medicine

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“…COVID-19 and diabetes mellitus are correlated in a bidirectional manner, according to research[ 26 ]. Diabetes mellitus is a common comorbidity among COVID-19 patients[ 27 ]. Diabetes exacerbates disease severity and mortality, increasing the probability of infection with SARS-CoV-2[ 28 ].…”

Section: Discussionmentioning

confidence: 99%

Assisting individuals with diabetes in the COVID-19 pandemic period: Examining the role of religious factors and faith communities

Eseadi¹,

Ossai²,

Onyishi³

et al. 2022

WJCC

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With the onset of the coronavirus disease 2019 (COVID-19) pandemic, diabetes management has become more challenging than it has ever been. Studies on the management of diabetes during this time are required. Unfortunately, the lack of information on the potential role of religious factors and faith communities in diabetes management during the COVID-19 era prevents us from fully understanding the issue of diabetes management during the COVID-19 pandemic period. People with chronic conditions such as diabetes may benefit from some form of religious support from faith communities and their ability to cope could be fostered by some religious factors. It is unclear how religious factors and faith communities contribute to diabetes management. In this article, the authors examine how people with diabetes can be aided in the COVID-19 pandemic period from the perspective of religious factors and faith communities. Based on the studies identified, it appears that religious factors and faith communities play an important role in managing diabetes among patients during the COVID-19 pandemic.

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“…Our study revealed that 28.4% of the study patients were diabetics. From a previous study, it was shown that patients with diabetes, compared to those without diabetes, had a 21.8% higher rate of COVID-19, threefold rates of COVID-19 pneumonia, and were more likely to be hospitalized, intubated, admitted to the ICU, and have a fatal outcome [16]. Our study is consistent with the hypothesis that patients with diabetes are more susceptible to infections caused by respiratory viruses such as SARS-CoV-2 virus.…”

Section: Discussionmentioning

confidence: 99%

Comorbidities and risk factors for COVID-19 in a group of Iraqi patients confirmed by real-time PCR test

Abbas¹,

Manhal²

2021

j. port. sci. res

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The aim of the study was to identify characteristic risk factors predisposing to coronavirus disease 2019 (COVID-19) outbreak in a group of Iraqi patients in Baghdad City. In this study, we included a total of 13411 persons who had been tested for COVID-19, supervised by Al-Razi Medical Center in Baghdad City during the period from June 20 to November 13, 2020. Cases were tested and divided into two groups according to the result of real-time RT-PCR test for COVID-19. A total of 1781 positive cases were detected with confirmed COVID-19. Comorbidities in the study patients were identified as hypertension, diabetes mellitus and respiratory disorders. Hypertension was the most common comorbidity in COVID-19 patients followed by diabetes mellitus. The results of this study showed that patients with comorbidities were significantly associated with positive RT-PCR results related to COVID-19. It was concluded that understanding the comorbidities enhance defining patients with COVID-19 at higher risk. Further research is needed to confirm and clarify the impact of the association of co-morbidities that accompany COVID-19.

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Diabetes increases the risk of COVID-19 in an altitude dependent manner: An analysis of 1,280,806 Mexican patients

Cited by 22 publications

References 68 publications

COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience

COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience

Assisting individuals with diabetes in the COVID-19 pandemic period: Examining the role of religious factors and faith communities

Comorbidities and risk factors for COVID-19 in a group of Iraqi patients confirmed by real-time PCR test

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