Diabetes in Birds

Sitbon, Gary; Laurent, F; Mialhe, Agnès; Krug, Eva; Karmann, H.; Gross, R; Strosser, M.T.; Cohen, Loren H.; Jean-Marie, P.; Foltzer, C.; Mialhe, P

doi:10.1055/s-2007-996183

Cited by 25 publications

(6 citation statements)

References 10 publications

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“…11,12 The plasma glucagon-to-insulin ratio in granivorous birds is also 5-10 times higher than in mammals. 3,13 These differences have led to the assumption that pet birds are more dependent on glucagon than on insulin for carbohydrate metabolism and glucose regulation. 14 In granivorous birds, glucagon possibly plays the major role in directing the distribution and destination of nutrient substrates because the high rate of avian metabolism requires a constantly high supply of carbohydrate.…”

Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus in a Chestnut-fronted Macaw (Ara severa)

Pilny¹,

Luong²

2005

Journal of Avian Medicine and Surgery

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Section: Discussionmentioning

confidence: 99%

Diabetes Mellitus in a Chestnut-fronted Macaw (Ara severa)

Pilny¹,

Luong²

2005

Journal of Avian Medicine and Surgery

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“…Metabolism of glucose is essential for insulin secretion, and inhibition of mitochondrial metabolism blocks insulin secretion [ 15]. Mechanisms of β cell glucose metabolism and metabolic signal generation have been recently reviewed [ 16].…”

Section: The Stimulus-secretion Coupling Mechanismmentioning

confidence: 99%

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

MacDonald¹,

Rorsman²

2006

PLoS Biol

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“…It also suggests, more generally, that the main factor controlling acute glycemic changes in the fly might be glucagon and not insulin. This is reminiscent of the situation in birds, where total pancreatectomy causes fatal hypoglycemia associated with the disappearance of circulating glucagon (7).…”

mentioning

confidence: 91%

Control of Metabolism and Growth Through Insulin-Like Peptides inDrosophila

et al. 2006

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Insulin signaling is a conserved feature in all metazoans. It evolved with the appearance of multicellularity, allowing primordial metazoans to respond to a greater diversity of environmental signals. The insulin signaling pathway is highly conserved in insects and particularly in Drosophila, where it has been extensively studied in recent years and shown to control metabolism, growth, reproduction, and longevity. Because misregulation of the insulin/IGF pathway in humans plays a role in many medical disorders, such as diabetes and various types of cancer, unraveling the regulation of insulin/IGF signaling using the power of a genetically tractable organism like Drosophila may contribute to the amelioration of these major human pathologies. Diabetes 55 (Suppl. 2):S5-S8, 2006

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Diabetes in Birds

Cited by 25 publications

References 10 publications

Diabetes Mellitus in a Chestnut-fronted Macaw (Ara severa)

Diabetes Mellitus in a Chestnut-fronted Macaw (Ara severa)

Oscillations, Intercellular Coupling, and Insulin Secretion in Pancreatic β Cells

Control of Metabolism and Growth Through Insulin-Like Peptides inDrosophila

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