Diabetes, impaired fasting glucose, and cognitive decline in a population of elderly community residents

Abstract

Our study showed that, in a sample of elderly non-demented community dwellers, diabetes mellitus (but not IFG) is associated with a higher decline in selective attention and executive functioning. These results emphasize the importance of detecting and man- aging diabetes and impaired fasting glucose, in order to prevent cognitive impairment and dementia.

Executive Function in Adults With Type 2 Diabetes

“…However, the current investigation is the most inclusive and comprehensive quantitative review to date in that it includes the broadest range of studies, examines each EF facet separately, and explores the impact of several potential moderators of ES. Despite the finding of an overall effect of T2DM status on EF, there was variability in findings between individual studies with some studies showing lower EF at a level that is statistically significant (19,22,42,46,50,51,58,72,74,77,78) and others showing no statistically significant effect of T2DM status (21,28,33,36,44,59,62,63,65,68). Possible explanations for this diversity include the broad array of research methodology used, sample characteristics (e.g., age range, sex distributions, and comorbitidies), and sample sizes.…”

Vascular comorbidities in younger people with dementia: a cross-sectional population-based study of 616 245 middle-aged people in Scotland

“…The largest meta-analysis of people with type 2 diabetes demonstrates an overall relative risk of 1.5 and 2.48 for those with Alzheimer's and vascular dementia, respectively 21. People with diabetes appear to have greater rate of cognitive decline in comparison to controls prior to the development of dementia per se 22 23. Interestingly, people in an older cohort with diabetes and additional vascular risk factors were found to have a greater risk of dementia than those who only have diabetes 24.…”

3 Dimensions of Care for Diabetes: integrating diabetes care into an individual's world

“…There are an estimated 28 000 people with diabetes in Lambeth and Southwark, and the Quality and Outcomes Framework data report that 22% have an HbA 1c >9%. The clinical problem is that about a third of people with diabetes (around 8500) have psychological and/or social problems interfering with their ability to self‐manage their diabetes . This leads to poorly controlled blood glucose control, increased risk of diabetes complications, premature mortality, worse quality of life and increased cost to the individual and the NHS …”