Diabetes, Hyperglycemia, and Infections

Effects of Preoperative Oral Carbohydrate Supplementation on Postoperative Metabolic Stress Response of Patients Undergoing Elective Abdominal Surgery

“…In view of this, we could not exclude the possibility that an ERAS is also related to lower rates of infection, which, in turn, have been associated with lower postoperative blood glucose [18,19]. Our data seem to confirm this observation, but the evidence is clearly unpowered by the small number of patients included here.…”

Analysis of non-relapse mortality and causes of death over 15 years following allogeneic hematopoietic stem cell transplantation

“…21 We adopted preemptive treatment using ganciclovir or valganciclovir against CMV based on weekly monitoring of C7-HRP (CMVpp65) since 2002. 22 As systemic steroid administration causes hyperglycemia, a well-established risk factor for infectious diseases, 23 better glucose control after allo-HSCT in recent years might have contributed to the reduced incidence of lethal infections in patients receiving systemic steroid administration for GVHD. 24 In addition, use of IV Ig for patients with low IgG value (o 500 mg/dL) may have helped decrease the incidence of severe infection.…”

Effects of Hibiscus sabdariffa Linn. Aqueous Extract on Oxidative Stress and T Lymphocyte Population in Spleen of Streptozotocin-induced Diabetic Rats

“…Kajian in vitro oleh Rubinstein dan rakan-rakan (2008) juga menunjukkan kesan keadaan hiperglisemia ke atas limfosit T di mana jumlah proliferasi serta bilangan limfosit T yang hidup adalah berkurangan dan berlaku peningkatan proses apoptosis limfosit T. Pengurangan proliferasi sel limfosit T CD4+ juga turut dinyatakan oleh Eibl dan rakanrakan (2002), di mana keadaan ini akan menyebabkan pengurangan dalam penghasilan antibodi oleh sel B yang bergantung kepada pengaktifan limfosit T CD4+. Selain itu keadaan hiperglisemia juga menyebabkan perubahan pada fungsi leukosit, perubahan tindak balas komplimen, perubahan tindak balas mikrovaskular dan perubahan pada penghasilan kemokin serta sitokin (Shilling & Raphael 2008).…”