Diabetes diagnostic thresholds of the glycated hemoglobin A1c and fasting plasma glucose levels considering the 5-year incidence of retinopathy

Nakagami, Tomoko; Takahashi, Kanako; Suto, Chikako; Oya, Junko; Tanaka, Yuki; Kurita, Moritoshi; Isago, Chisato; Hasegawa, Yukiko; Ito, Arata; Uchigata, Yasuko

doi:10.1016/j.diabres.2016.12.013

Cited by 21 publications

(15 citation statements)

References 27 publications

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“…HbAlc levels represent a patient's blood sugar level over the past 3 months and are an important indicator of DR (17). Effective control of blood sugar may reduce the incidence of DR.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted imaging of injuries to the visual centers of the brain in patients with type 2 diabetes and retinopathy

Liang

Chen

Xue

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. The present study aimed to investigate the ability of diffusion-weighted imaging (DWI) to identify injury to the visual centers of the brain in patients with type 2 diabetes with retinopathy. The study included 84 cases (63 patients with type 2 diabetic retinopathy and 21 healthy individuals) that were assessed using DWI. Diabetic patients were equally divided into three groups: Proliferative diabetic retinopathy (PDR), non-proliferative diabetic retinopathy (NPDR) and diabetic without retinopathy. The results demonstrated that individuals in the PDR group had significantly higher disease duration and glycated hemoglobin levels than the diabetic without retinopathy group (P<0.05). Apparent diffusion coefficient (ADC) values were significantly higher in functional brain areas of the PDR group compared with the NPDR group (P<0.001), whose values were significantly higher compared with the diabetic without retinopathy and control groups (P<0.001). In addition, glycated hemoglobin levels and disease duration were positively correlated with mean ADC values in the same functional areas of the brain. In conclusion, DWI-measured ADC values may be an effective indicator of brain dysfunction in individuals with type 2 diabetic retinopathy. DWI is able to assess brain injury in individuals with early diabetic retinopathy, which may make the diagnostic technique a useful predictor of early ocular disease.

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“…HbAlc levels represent a patient's blood sugar level over the past 3 months and are an important indicator of DR (17). Effective control of blood sugar may reduce the incidence of DR.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-weighted imaging of injuries to the visual centers of the brain in patients with type 2 diabetes and retinopathy

Liang

Chen

Xue

et al. 2017

Experimental and Therapeutic Medicine

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“…These criteria are based on venous samples and laboratory methods (14). A fasting plasma glucose (FPG) level of 7.0 mmol/L correlates most closely with a 2-hour plasma glucose (2hPG) value of ≥11.1 mmol/L in a 75 g oral glucose tolerance test (OGTT), and each predicts the development of retinopathy (15). The relationship between A1C and retinopathy is similar to that of FPG or 2hPG with a threshold at around 6.5% (2,(16)(17)(18)(19)(20)(21)(22).…”

Section: Diabetesmentioning

confidence: 99%

Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome

Punthakee¹,

Goldenberg²,

Katz³

2018

Canadian Journal of Diabetes

631

410

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“…In our study, glycated hemoglobin was found to be a good test for predicting complications (OR=3.06; p= 0.0073) (Table 2) and was reinforced by other work. Nakagami et al (2017) have shown the risks of incident retinopathy and diabetic retinopathy were positively, continuously, and independently associated with HbA1C and fasting plasma glucose (FPG) levels in their cohort of Japanese participants without a previous history of diabetes. Furthermore, the adjusted hazard ratio for retinopathy were significantly higher in participants with an HbA1C level ≥6.5% or FPG level ≥7.0 mmol/L at baseline, relative to participants in the lowest categories of these variables (Nakagami et al, 2017).…”

Section: Occurrence Of Complicationsmentioning

confidence: 99%

“…Nakagami et al (2017) have shown the risks of incident retinopathy and diabetic retinopathy were positively, continuously, and independently associated with HbA1C and fasting plasma glucose (FPG) levels in their cohort of Japanese participants without a previous history of diabetes. Furthermore, the adjusted hazard ratio for retinopathy were significantly higher in participants with an HbA1C level ≥6.5% or FPG level ≥7.0 mmol/L at baseline, relative to participants in the lowest categories of these variables (Nakagami et al, 2017). Also, Stratton et al (2000) in the United Kingdom Prospective Diabetes Study Group (UKPDS) work on type 2 diabetes showed that the risk of myocardial infarction and microvascular complications decreased by 14 and 37%, respectively for any 1% decrease in HbA1C.…”

Section: Occurrence Of Complicationsmentioning

confidence: 99%

Correlation between glycated hemoglobin and venous blood sugar in diabetic patients monitored in Abidjan

Absalome¹,

Camara-Cisse²,

Gervais³

et al. 2020

Afr. J. Biochem. Res.

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The aim of this study was to determine the correlation between glycated hemoglobin and blood sugar levels in diabetic subjects carried out in Abidjan. This cross-sectional study included 100 patients with diabetes monitored, for three months, for whom glycated blood glucose and hemoglobin were performed, this after informed consent of the patients. Pearson and Spearman correlation tests were used, at the 5% threshold. The patients with normal HbA1C and normal blood glucose accounted for 55.34 and 32%, respectively. A sedentary lifestyle and body mass index > 25 kg/m² were associated with a significant increase in the risk of increased blood glucose and HbA1C. The presence of a complication was associated with a 3.06-fold higher risk of high glycated hemoglobin (p= 0.0073), while blood glucose was not significantly associated with the onset of complications. Glycated hemoglobin was significantly correlated with blood glucose with a correlation coefficient of 0.4412 (p 0.0001). In multivariate analysis, hyperglycemia was significantly associated with alcohol consumption and noncompliance with antidiabetic treatment. Poor compliance was significantly associated with increased glycated hemoglobin (>7%) and tobacco consumption. The glycated hemoglobin was highly correlated with blood sugar, and was found to be a better predictor of diabetes complications than glycemia.

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Diabetes diagnostic thresholds of the glycated hemoglobin A1c and fasting plasma glucose levels considering the 5-year incidence of retinopathy

Cited by 21 publications

References 27 publications

Diffusion-weighted imaging of injuries to the visual centers of the brain in patients with type 2 diabetes and retinopathy

Diffusion-weighted imaging of injuries to the visual centers of the brain in patients with type 2 diabetes and retinopathy

Definition, Classification and Diagnosis of Diabetes, Prediabetes and Metabolic Syndrome

Correlation between glycated hemoglobin and venous blood sugar in diabetic patients monitored in Abidjan

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