Diabetes and pancreatic cancer: Exploring the two-way traffic

Roy, Ayan; Sahoo, Jayaprakash; Kamalanathan, Sadishkumar; Naik, Dukhabandhu; Mohan, Pazhanivel; Kalayarasan, Raja

doi:10.3748/wjg.v27.i30.4939

Cited by 45 publications

(51 citation statements)

References 200 publications

(241 reference statements)

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“…As for prognosis, T2DM did not affect the OS or DFS on different stages of CRC after PSM, furthermore, T2DM was not an independent predictor of OS or DFS. T2DM increased the global medical burden and economic burden, 6,7 and furthermore, T2DM could increase the incidence of digestive cancers including esophageal cancer, 17 gastric cancer 18 and CRC. 12 However, there remained controversial about the outcomes of T2DM on CRC.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 Type 2 diabetes mellitus (T2DM) causes a significant burden on patients and society globally, 6 and T2DM accounts for increased morbidity and mortality. 7 The number of T2DM patients is expected to reach 700 million in 2045. 8 Cancer and T2DM are two global public health problems and are also regarded as the world's major lethal and disabling diseases.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I–III Colorectal Cancer: A Propensity Score Matching Analysis

Cheng¹,

Cheng²,

Liu³

et al. 2022

CMAR

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Purpose:The purpose of the current study was to analyze the effect of type 2 diabetes mellitus (T2DM) on the short-term outcomes and prognosis of stage I-III colorectal cancer (CRC) undergoing primary surgery. Methods: Patients who underwent primary CRC surgery were retrospectively collected from Jan 2011 to Jan 2020 in a single clinical center. The short-term outcomes and prognosis were compared between T2DM group and non-T2DM group using propensity score matching (PSM) analysis. Results: A total of 4250 patients were included in this study. There were 521 patients with T2DM and 3729 patients without T2DM. After 1:1 ratio PSM, there were 519 T2DM patients and 519 non-T2DM patients left in this study. No significant difference was found in baseline information after PSM (p>0.05). T2DM had higher overall complications (p=0.033) after PSM in terms of short-term outcomes. As for prognosis, T2DM group had worse overall survival (OS) in all stages (p=0.044), stage I (p=0.009) and stage II (p=0.021) of CRC and T2DM group had worse disease-free survival (DFS) than non-T2DM group in stage I (p=0.008) of CRC before PSM. However, T2DM did not affect the overall survival (OS) or disease-free survival (DFS) on different stages of CRC after PSM (p>0.05). Moreover, T2DM was not an independent predictor of OS or DFS (p>0.05). Conclusion: T2DM increased overall complications after primary CRC surgery. However, T2DM might not affect OS and DFS of stage I-III CRC patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I–III Colorectal Cancer: A Propensity Score Matching Analysis

Cheng¹,

Cheng²,

Liu³

et al. 2022

CMAR

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“…Особый интерес представляет развитие гипергликемии у пациентов со злокачественными опухолями поджелудочной железы. Известно, что СД может быть первым проявлением рака поджелудочной железы и манифестирует в среднем за 2-3 года до его диагностики [11]. В крупном когортном исследовании, включавшем 2,3 млн граждан Израиля, риск диагностики рака поджелудочной железы в первый год после установления диагноза СД был значимо повышен среди как мужчин, так и женщин (отношение шансов 15,24 и 13,88 соответственно) [12].…”

Section: эндокринологияunclassified

Carbohydrate metabolism in patients after pancreatoduodenal resection

et al. 2022

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Introduction. Pancreatic resection is a common surgical treatment option for chronic pancreatic diseases. Diabetes mellitus, which develops as a result of surgical interventions on the pancreas, belongs to a specific type – pancreatogenic. To assess the state of carbohydrate metabolism in patients after surgery in the volume of pancreatoduodenal resection (PDR), a retrospective single-stage single-center study was performed.Aim. Assessment of the state of carbohydrate metabolism in patients after surgery in the volume of PDR.Materials and methods. In Botkin City Clinical Hospital 70 case histories of patients who underwent PDR were selected. The reason for the PDR was pancreatic head cancer (55 people), chronic pancreatitis (7 people), chronic calculous pancreatitis (8 people). Data on age, gender, date of surgery, glycemia levels before and after surgery, as well as C-peptide, insulin, and HbA1c were analyzed.Results. Out of 70 people in the initial group, diabetes mellitus was diagnosed before surgery in 8 people or in 11.5% of the entire sample. Indicators of carbohydrate metabolism did not differ significantly from each other. However, the level of C-peptide decreased in all patients, while in the group of patients with malignant tumors of the pancreas, despite the decrease in C-peptide, the level of fasting glycemia also decreased.Conclusion. If before the operation diabetes mellitus was diagnosed in 11.5% of patients, then after the operation the diagnosis of diabetes mellitus was established in 23.6%. Late detection of diabetes mellitus worsens not only the quality of life of patients, but also the overall prognosis, morbidity, and tolerability of chemotherapy. Obviously, the postoperative monitoring algorithm should include regular monitoring of glycemia, glycated hemoglobin at least once a year with normoglycemia in order to early diagnose carbohydrate metabolism disorders and prescribe therapy.

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“…Однако в целом данные о влиянии терапии инсулином на риск РПЖ по-прежнему противоречивы [15; 21]. В настоящее время нет четких доказательств риска развития ПК при использовании препаратов на основе инкретинов [18], а методологические недостатки исследований, посвященных применению сульфонилмочевины, не позволяют сделать однозначный вывод [15]. Глифлозины, по меньшей мере, не связаны с риском РПЖ у пациентов с СД2, а возможно могут обладать позитивными плеойтропными эффектами [22] Результаты многочисленных исследований демонстрируют, что среди известных факторов риска РПЖ особое место занимает СД, впервые выявленный, при котором риск РПЖ в несколько раз выше, чем при длительно существующем СД2 (табл.…”

Section: Noteunclassified

Pancreatic cancer, pancreatogenic diabetes, type 2 diabetes mellitus

Друк

2022

jour

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Pancreatic cancer (PC) is the fourth leading cause of death among all types of cancer. PC is very aggressive with a low 5-year overall survival rate. The highest prevalence of diabetes mellitus (DM), significantly exceeding the average population, is registered among patients with prostate cancer Recommendations for systemic screening of patients with diabetes for the detection of PC are not standardized. The purpose of this review is to present an analysis of current literature data on pathogenetic relationships between DM and PC and prospects for PC screening. Research data indicate that there is a bidirectional relationship between DM and PC, in which DM can act either as a risk factor for PC or as a marker of paraneoplastic syndrome of PC. In the differential diagnosis of type 2 diabetes, pancreatogenic diabetes and diabetes associated with PC, a set of clinical signs can be used. Patients with DM who have additional signs/symptoms of increased risk can be considered as a group subject to mandatory screening. Numerous studies of various proteomic, metabolomic, genetic and transcriptomic biomarkers PC have been published. The search for an easy-to-use clinically useful and cost-effective PC marker is still ongoing.

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Diabetes and pancreatic cancer: Exploring the two-way traffic

Cited by 45 publications

References 200 publications

The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I–III Colorectal Cancer: A Propensity Score Matching Analysis

The Effect of Type 2 Diabetes Mellitus on the Short-Term Outcomes and Prognosis of Stage I–III Colorectal Cancer: A Propensity Score Matching Analysis

Carbohydrate metabolism in patients after pancreatoduodenal resection

Pancreatic cancer, pancreatogenic diabetes, type 2 diabetes mellitus

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