Diabetes and Kidney Disease: Role of Oxidative Stress

Jha, Jay C.; Banal, Claudine; Chow, Bryna S. M.; Cooper, Mark E.; Jandeleit‐Dahm, Karin

doi:10.1089/ars.2016.6664

Cited by 449 publications

(424 citation statements)

References 290 publications

(413 reference statements)

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“…45) Moreover, it has been reported that all forms of acute and chronic renal injuries, regardless of species, is associated with enhanced generation of ROS, 46) which linked ROS to renal damage. Besides, cell senescence also plays a pivotal role in renal damage.…”

Section: Hfd and Hg Culture Comparisonmentioning

confidence: 99%

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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Obesity-related renal diseases have been a worldwide issue. Effective strategy that prevents high fat-diet induced renal damage is of great significance. Resveratrol, a natural plant polyphenol, is famous for its antioxidant activity, cardioprotective effects and anticancer properties. However whether resveratrol can play a role in the treatment of renal diseases is unknown. In this study, we added resveratrol in normal glucose or high glucose medium and provide evidences that resveratrol protects against high-glucose triggered oxidative stress and cell senescence. Moreover, mice were fed with standard diet, standard diet plus resveratrol, high-fat diet or high-fat diet plus resveratrol for 3 months, and results show that resveratrol treatment prevents high-fat diet induced renal pathological damage by activating SIRT1, a key member in the mammalian sirtuin family that response to calorie restriction life-extension method. This research confirms the potential role of resveratrol in the treatment of renal diseases and may provide an effective and convenient method to mimic the beneficial effects of calorie restriction.

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Section: Hfd and Hg Culture Comparisonmentioning

confidence: 99%

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Zhang

et al. 2016

Biological & Pharmaceutical Bulletin

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“…Nox family is one of the major contributors on ROS generation in the kidney [10]. Our previous studies with db/db and STZ-induced mice have implied increases of protein and mRNA levels of renal Nox 1, 2, and 4, which were significantly reduced by APX-115, a panNox inhibitor [17,18].…”

Section: Discussionmentioning

confidence: 95%

“…Accumulation of reactive oxygen species (ROS) leads to renal inflammation and structural changes in the kidney, stimulating the pathological process of DKD [6][7][8]. Among signaling molecules involved in renal ROS generation, NADPH oxidases (Nox) belongs to an enzyme system majorly contributing to the pathophysiology of DKD [9,10]. The kidneys express several Nox isoforms, Nox1, Nox2, Nox4, and Nox5 present in mesangial, podocyte, glomerular endothelial, and tubulointerstitial cells.…”

Section: Introductionmentioning

confidence: 99%

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A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats

et al. 2018

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Background: NADPH oxidases (Nox) is a major enzyme system contributing to oxidative stress, which plays an important role in the pathogenesis of diabetic kidney disease (DKD). We have shown an elevation of renal Nox1, Nox2, and Nox4 in diabetic mice. APX-115, a pan-Nox inhibitor, attenuated the progression of DKD in mice. As the standard diabetic mice cannot fully mimic human DKD, the present study was aimed to show the dose-dependent effect and to provide a confirmatory evidence of APX-115 in attenuating DKD in diabetic rats. Method: Type 1 diabetes was induced by a single 60 mg/kg intraperitoneal injection of streptozotocin in Sprague-Dawley rats. 0.5, 5, or 30 mg APX-115/kg/day or losartan 1 mg/kg/day were administered orally to diabetic rats for 8 weeks. Results: APX-115 treatment showed an improvement in kidney function and tubular and podocyte injury, as well as attenuation of inflammation, fibrosis, and oxidative stress as much as losartan, a comparative drug and mainstay treatment in DKD. Therapeutic effect of APX-115 was exhibited in a dose-dependent manner; a dose of 30 mg/kg displayed a superior efficacy. Conclusion: This finding verified the pre-clinical data of APX-115 in protecting against DKD, which is important to bring APX-115 toward the next stage of drug development.

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“…Erythropoietin deficiency is the predominant cause of anemia in kidney diseases (Babitt and Lin, 2012) due to the fact that kidney is the main source of erythropoietin. So also, oxidative stress has been implicated in the genesis and progression of kidney diseases (Jha et al, 2016), long-chain polyunsaturated fatty acids present in the kidney enhance the oxidative stress-induced kidney disease.…”

mentioning

confidence: 99%

Effect of aqueous <i>Allium cepa</i> extract from red onion on aluminum chloride- induced anemia in female rats

Ige¹,

Aiyeola²

2018

Journal of Applied Sciences and Environmental Management

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This study examined the protective effect of Allium cepa extract from red onion on aluminuminduced anemia in female wistar rats. Twenty-four animals (six rats per group) were used for this study. They were divided into four groups: group one served as control, group two animals were treated with 100mg/kg BW of aluminum chloride and served as Aluminum chloride (AlCl3) group, group three, Allium cepa alone group were treated with 1mL/100g BW of Allium cepa while group four was simultaneously treated with 1mL/100g BW of Allium cepa and 100mg/kg BW AlCl3. Treatments lasted for 4 weeks. Red blood cells (RBC), packed cell volume (PCV), Hemoglobin concentration (Hb) were measured from blood sample collected from each rat. Serum urea, serum and kidney malondialdehyde (index of lipid peroxidation) and kidney catalase and superoxide dismutase (SOD) activities were measured spectrophotometrically. Significant decrease in RBC, PCV, Hb, catalase, SOD and significant increase in serum urea and malondialdehyde were observed in aluminum treated animals when compared with control. Animals treated with Allium cepa alone had significant increase in PCV, Hb, SOD and significant decrease in malondialdehyde and serum urea while there was no significant different in RBC and catalase when compared with control. Simultaneous treatment of the animals with Allium cepa and aluminum chloride resulted in significant increase in PCV while there was no significant different in RBC, Hb, catalase, malondialdehyde when compared with control.This study reveals that Allium cepa extract treatment ameliorate aluminum-induced anemia through antioxidant system.

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Diabetes and Kidney Disease: Role of Oxidative Stress

Cited by 449 publications

References 290 publications

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

Resveratrol Protects against High-Fat Diet Induced Renal Pathological Damage and Cell Senescence by Activating SIRT1

A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats

Effect of aqueous <i>Allium cepa</i> extract from red onion on aluminum chloride- induced anemia in female rats

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