Diabetes and Impaired Glucose Tolerance in Three Alaskan Eskimo Populations: The Alaska-Siberia Project

Ebbesson, Sven O K; Schraer, Cynthia D; Risica, Patricia Markham; Adler, Amanda I; Ebbesson, Lars O.E.; Mayer, Ann Marie; Shubnikof, Eugene V; Yeh, Jeunliang; Go, Oskar T; Robbins, David C.

doi:10.2337/diacare.21.4.563

Cited by 82 publications

(85 citation statements)

References 12 publications

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“…19 The percentage of eligible residents that participated in the screening clinic was 69% among the Central Yupik, 55% among the Inupiat, and 44% among the Siberian Yupik people. Participation was higher for the older age groups with 66% of those !45 y and 41% of those`45 y participating.…”

Section: Resultsmentioning

confidence: 99%

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Overweight and obesity among Alaskan Eskimos of the Bering Straits region: the Alaska Siberia Project

Risica

Schraer

Ebbesson³

et al. 2000

Int J Obes

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OBJECTIVE: To document the height, weight, BMI and prevalence of obesity for Eskimo residents of four villages of the Bering Straits Region of Alaska. DESIGN AND SUBJECTS: 454 Non-pregnant residents over 24 y of age, with at least one Eskimo grandparent participated in one cross sectional survey within each village. MEASUREMENTS: Height, weight, calculation of BMI (kgam 2 ), proportion of`overweight' (BMI 25 ± 29.9), and proportion of`obese' (BMI !30). RESULTS: For women and men, respectively, mean heights were 153.4 and 165.2 cm; weights were 64.2 and 71.6 kg; and BMI were 27.2 and 26.2 kgam 2 after age standardization. For women, 27.9% were overweight, and 32.8% were obese compared with 36.2% and 15.6%, respectively, for men. Alaskan Eskimo participants of the Alaska Siberia Project had a signi®cantly lower proportion of total overweight (BMI !25, 54.9% for women, and 32.0% for men) compared with the three sites of the Strong Heart Study, which ranged from 65.9 to 80.2% for women and 53.6 to 66.7% for men. Compared with American men of all races, the proportion of overweight and obese participants was similar for Eskimo men. The proportion of obese was signi®cantly higher for Eskimo women compared with American women of all races, but the proportion of overweight was similar. CONCLUSION: Although the prevalence of obesity among the Alaskan Eskimos is lower than for American Indians, the high proportion of overweight observed in this study is of concern for Alaskan Eskimo adults, especially for women.

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Section: Resultsmentioning

confidence: 99%

“…26 ± 30 Welty detailed the health implications of obesity for American Indians and Alaska Natives, which include diabetes, cardiovascular disease and hypertension among other maladies. 31 For Alaska Natives speci®cally, both Murphy et al 2 and this project 19 have demonstrated an association of BMI with glucose intolerance.…”

Section: Discussionmentioning

confidence: 99%

Overweight and obesity among Alaskan Eskimos of the Bering Straits region: the Alaska Siberia Project

Risica

Schraer

Ebbesson³

et al. 2000

Int J Obes

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show abstract

“…25 The western lifestyle implies a larger intake of food with a high glycaemic load 26 and less developed societies adopting the western dietary pattern experience increasing incidences of hyperglycaemia, insulin resistance, hyperinsulinaemia, and type 2 diabetes. 27,28 A high glycaemic load imposes acute and chronic hyperinsulinaemia, 25 and a large intake of sucrose lowers the insulin sensitivity 29 and blocks the binding of insulin to the receptor. 30 Cordain et al 25 argue that high glycaemic load and the resulting hyperinsulinaemia affect different growth factors resulting in scleral growth.…”

Section: Diet and Diabetesmentioning

confidence: 99%

Genetic and environmental effects on myopia development and progression

Goldschmidt¹,

Jacobsen

2013

Eye

115

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“…Members of these more natural populations are protected from the illnesses of civilization only as long as they live their native lifestyle. As soon as they move to cities and accommodate to more modern conditions, the incidence of chronic diseases (among them acne) increases [19,21,28].…”

Section: The Early Years: Twin Family Community-based and Cross-sementioning

confidence: 99%

Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

Szabó

Kemény

2011

Human Immunology

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A B S T R A C TAcne is one of the most common dermatologic diseases in the developed regions of the world, affecting a large percentage of the population. Despite the great improvement in the number and quality of studies of the molecular etiology of this disease in the past 3 decades, the detailed molecular pathogenesis and the cause of the large individual variations in severity of skin symptoms remain unknown. The roles of genetic inheritance and special genetic susceptibility and protective factors have been suggested for over 100 years, but their identification and determination started only in the 1990s. To date, only a small number of genetic polymorphisms affecting the expression and/or function of a handful of genes have been investigated. This review surveys the major findings of the classic and molecular genetic studies that have been conducted in this field, draws conclusions, and indicates how the available data help our current understanding of the pathogenesis of this common skin disease. ᭧

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Diabetes and Impaired Glucose Tolerance in Three Alaskan Eskimo Populations: The Alaska-Siberia Project

Abstract: These prevalences of diabetes are the highest yet reported among Eskimo populations. Obesity and family history of diabetes are associated with increased odds of developing diabetes. These data underscore the need to further examine risk factors and to design effective interventions.

Cited by 82 publications

References 12 publications

Overweight and obesity among Alaskan Eskimos of the Bering Straits region: the Alaska Siberia Project

Overweight and obesity among Alaskan Eskimos of the Bering Straits region: the Alaska Siberia Project

Genetic and environmental effects on myopia development and progression

Studying the genetic predisposing factors in the pathogenesis of acne vulgaris

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