Diabetes and hypertension

Lago, Rodrigo M.; Singh, Premranjan P.; Nesto, Richard W.

doi:10.1038/ncpendmet0638

Cited by 152 publications

(100 citation statements)

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“…These diseases have been responsible for the high incidence of chronic kidney disease (Lago et al, 2007;Wannamethee et al, 2005). DM is directly related to dyslipidemia, which leads to the development of accelerated atherosclerosis and gives rise to macrovascular complications such as myocardial infarction, stroke and peripheral vascular insufficiency, and microvascular complications that lead to retinopathy, nephropathy and neuropathy in patients with DM types 1 and 2 (Knudson et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Detecting alterations of glucose and lipid components in human serum by near-infrared Raman spectroscopy

et al. 2015

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Introduction: Raman spectroscopy may become a tool for the analysis of glucose and triglycerides in human serum in real time. This study aimed to detect spectral differences in lipid and glucose components of human serum, thus evaluating the feasibility of Raman spectroscopy for diagnostic purposes. Methods: A total of 44 samples of blood serum were collected from volunteers and submitted for clinical blood biochemical analysis. The concentrations of glucose, cholesterol, triglycerides, and low-density and high-density lipoproteins (LDL and HDL) were obtained using standard biochemical assays. Serum samples were placed in Eppendorf tubes (200 µL), kept cooled (5 °C) and analyzed with near-infrared Raman spectroscopy (830 nm, 250 mW, 50 s accumulation). The mean spectra of serum with normal or altered concentrations of each parameter were compared to determine which Raman bands were related to the differences between these two groups.Results: Differences in peak intensities of altered sera compared to normal ones depended on the parameter under analysis: for glucose, peaks were related to glucose; for lipid compounds the main changes occurred in the peaks related to cholesterol, lipids (mainly triolein) and proteins. Principal Components Analysis discriminated altered glucose, cholesterol and triglycerides from the normal serum based on the differences in the concentration of these compounds. Conclusion: Differences in the peak intensities of selected Raman bands could be seen in normal and altered blood serum samples, and may be employed as a means of diagnosis in clinical analysis.

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Section: Introductionmentioning

confidence: 99%

Detecting alterations of glucose and lipid components in human serum by near-infrared Raman spectroscopy

et al. 2015

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“…In patients with normal blood glucose concentration, the high levels of creatinine and urea observed in patients with affections were driven by nephropathies (p<0.05) (Figures 2 and 3), whereas patients with uncontrolled blood glucose significantly high levels of creatinine and urea were observed in both patients with hypertension (no nephropathy) and patient with nephropathy (p<0.001) (Figures 4 and 5). The fact that urea and creatinine were significantly higher in diabetics with associated affections is not that surprising, as the impact diabetes disease and hypertension on kidney function is well established [14][15][16][17][18]. One interesting observation is that uncontrolled blood glucose levels associated with hypertension significantly strained kidney function as shown by the Figures 4 and 5, thereby increasing the risk of nephropathy [19][20][21].…”

Section: Resultsmentioning

confidence: 75%

Metabolic Deregulation Associated with Glycemic Imbalance In Gabonese Diabetics

Padzys¹,

Tiagni²,

Ngou-Milama³

et al. 2017

Diabetes Case Rep

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Aim: Diabetes is a metabolic disease most often associated with complications when uncontrolled. The present study aimed to investigate the relationship between diabetes-associated complications, glycemic imbalances and other metabolic deregulation in Gabonese diabetics.Methods: 115 known diabetics were recruited from the Libreville University hospital. We collected anthropometric data and information on associated pathologies. Blood samples collected were analyzed for blood glucose, urea, creatinine, triglycerides, cholesterol fractions and transaminases.Results: Type-2 diabetes was more prevalent in the studied population, representing 90% of cased cases. 41.7% had diabetes cases were associated with hypertension alone. 9.6% of diabetes cases had kidney failure (associated or not with hypertension and/or neuropathy). 87% patients had uncontrolled blood sugar. Creatinine and urea were significantly higher in patients with affections as compared to patients without affections (p<0.0001). In diabetics with controlled blood glucose concentration, only patients with the nephropathy had significantly high levels of creatinine and urea (p<0.05). In diabetics with uncontrolled blood glucose concentration, significantly high levels of creatinine and urea were seen in both patients with hypertension and patient with nephropathy (p<0.001). Conclusion:The high rate of hypertension and hyperglycemia observed suggest that Gabonese diabetics are at high risk for developing nephropathies.

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“…Having diabetes leads to hypertension and other heart and circulation problems more likely, because diabetes damages arteries and makes them targets for hardening (atherosclerosis) [35]. Atherosclerosis can cause hypertension, which if not treated, can lead to blood vessel damage, stroke, heart failure, heart attack, or kidney failure [44][45][46]. Our data show that the mean arterial blood pressure (MAP) was above 100 mmHg in more than half of the conscious monkeys measured by the tail cuff method ( Figure 7A).…”

Section: Discussionmentioning

confidence: 99%

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part I. Model of Naturally Occurring Diabetes

Wang¹,

Wang²,

Sun³

et al. 2015

J Diabetes Metab

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Insulin-resistant diabetes (Type 2 diabetes mellitus, T2DM) is one of the main comorbidities of obesity and is the most common form of diabetes. T2DM and obesity dynamically influence each other and often escalate patients' other health issues. Cardiovascular, renal and other health consequences of obesity and diabetes have been studied for several decades. However, the underlying precise mechanisms and interactions of obesity and insulin-resistant diabetes have yet to be elucidated further. It has been recognized that sustained greater energy intake than expenditure is the main cause of obesity that can potentially lead to insulin resistance and diabetes due to excessive fat accumulation. To better understand the pathophysiology of human obesity and diabetes, nonhuman primate (NHP) models have been used for research to delineate molecular and cellular mechanisms because of the similarity of the metabolic diseases between NHP and humans. Also, NHP models have been well used for testing new novel therapies, which provides critical pre-clinic information for drug discovery. This article summarizes the data collected from a large scale of the naturally occurring diabetes monkeys housed in our facility. Manuscripts for other NHP models, such as diet-induced dyslipidemia and dysglycemia and streptozocin-induced diabetes, developed in our facility will follow lately. Dysglycemia and Dyslipidemia Models in Journal of Diabetes and MetabolismCitation: Wang X, Wang B, Sun G, Wu J, Liu Y, et al. (2015) This article introduces the characteristics of one NHP diabetic model, naturally occurring diabetes, which has been highly valuable for research and treatment of dyslipidemia and dysglycemia [14][15][16][17]. Other NHP models, such as diet-induced dyslipidemia and dysglycemia and streptozocin-induced diabetes, developed in our facility will be introduced lately via other manuscripts. While no single model is necessarily applicable to every dysmetabolic research program and drug discovery, it has been suggested that certain models have great validity. Therefore, if possible, selectively using of those preferable models to achieve the best potential outcome is recommended in order to address the very challenging diseases, obesity and diabetes. Normal and obese/diabetic monkeys housed in our animal center are collected periodically from the monkey farms in China and then raised in our own facility with a normal calorie monkey chow (Beijing Keao Xieli Feed Co., LTD, Beijing, China) enriched with seasonal fruits and vegetables in accordance with the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC) regulations and guidelines [18][19][20]. All the procedures for sample or data collection used in this study were approved by the Institutional Animal Care and Use Committee (IACUC) (Crown Bioscience, Inc., Taicang, Jiangsu province, The People's Republic of China) [18][19][20]. Animal grouping and their general characteristicsAs humans and other great apes (Hominoidea) diverged from Old World m...

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Diabetes and hypertension

Cited by 152 publications

References 0 publications

Detecting alterations of glucose and lipid components in human serum by near-infrared Raman spectroscopy

Detecting alterations of glucose and lipid components in human serum by near-infrared Raman spectroscopy

Metabolic Deregulation Associated with Glycemic Imbalance In Gabonese Diabetics

Dysglycemia and Dyslipidemia Models in Nonhuman Primates: Part I. Model of Naturally Occurring Diabetes

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