2014
DOI: 10.1016/j.juro.2014.07.013
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DHH is an Independent Prognosticator of Oncologic Outcome of Clear Cell Renal Cell Carcinoma

Abstract: To our knowledge we report for the first time that a biomarker of the HH pathway is associated with adverse pathological features and poor disease outcomes in patients with clear cell renal cell carcinoma. DHH may serve as an independent predictor of cancer specific survival in clear cell renal cell carcinoma cases. This supports further evaluation of HH signaling to validate the pathway as a target for novel therapy.

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Cited by 21 publications
(17 citation statements)
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“…5'-AUAGUGAAUUAAGCUUCGCGAGUUAUAG-3' such as the synthetic contribution of hypoxia inducible factor 1 (HIFlα) and CD74 to inhibiting KIRC cells' growth and invasion, 26 and the independently predictive role of DHH for KIRC prognosis. 27 In this investigation, MALAT1 was observed to differentially express within KIRC tissues and adjacent normal tissues, manifesting that this lncRNA potentially marked the onset and progression of KIRC ( Figure 1). Virtually, MALAT1 was ubiquitously expressed with a conservation degree of up to 90% among humans and mice, and the transcriptional products of MALAT1 were extremely stable due to that the triple helix structure in its 3′-end could prevent its degradation.…”
Section: Acvr2b Was Targeted By Mir-194-5p In Kirc Cellsmentioning
confidence: 58%
See 1 more Smart Citation
“…5'-AUAGUGAAUUAAGCUUCGCGAGUUAUAG-3' such as the synthetic contribution of hypoxia inducible factor 1 (HIFlα) and CD74 to inhibiting KIRC cells' growth and invasion, 26 and the independently predictive role of DHH for KIRC prognosis. 27 In this investigation, MALAT1 was observed to differentially express within KIRC tissues and adjacent normal tissues, manifesting that this lncRNA potentially marked the onset and progression of KIRC ( Figure 1). Virtually, MALAT1 was ubiquitously expressed with a conservation degree of up to 90% among humans and mice, and the transcriptional products of MALAT1 were extremely stable due to that the triple helix structure in its 3′-end could prevent its degradation.…”
Section: Acvr2b Was Targeted By Mir-194-5p In Kirc Cellsmentioning
confidence: 58%
“…Plenty of documentations also related various genes with KIRC, such as the synthetic contribution of hypoxia inducible factor 1 (HIF‐lα) and CD74 to inhibiting KIRC cells’ growth and invasion, and the independently predictive role of DHH for KIRC prognosis . In this investigation, MALAT1 was observed to differentially express within KIRC tissues and adjacent normal tissues, manifesting that this lncRNA potentially marked the onset and progression of KIRC (Figure ).…”
Section: Discussionmentioning
confidence: 69%
“…Over-expression of SHH, DHH and GLI1 was significantly correlated with advanced stages and tumour grades of the cohort. Activation of hedgehog pathway in advance cancer stages has been reported previously in breast [ 25 , 32 ], ovarian [ 18 ], renal [ 19 ] and prostate cancer [ 10 ]. Concomitantly, dysregulation of SHH, DHH and GLI-1 in the cohort has also been related with nodal involvement and metastasis.…”
Section: Discussionmentioning
confidence: 82%
“…Both IHH and SHH are highly expressed in human gastric cancer . DHH has prognostic value in clear cell renal cell carcinoma whereas IHH plays a role in squamous cell carcinoma progression and metastasis . In human osteosarcoma cell lines, IHH has been found to be upregulated, and inhibition of signaling leads to decreased xenograft tumor size .…”
Section: Discussionmentioning
confidence: 99%