LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR‐194‐5p/ACVR2B signaling

Ye, Yanle; Zhang, Feng; Chen, Qingxia; Huang, Zhiyu; Li, Meijun

doi:10.1002/mc.22926

Cited by 43 publications

(47 citation statements)

References 48 publications

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“…Interestingly, higher ACVR2B gene expression levels were also associated to increased proliferation in our series of lung carcinoids (as determined by Ki-67 index). Thus, although both miR-409-3p and miR-409-5p were in the original study associated also with positive nodal status (with a trend but not statistical significance in the present study, data not shown), our data strongly suggest that loss of miR-409-3p and miR-409-5p tumor suppressor activity in lung carcinoids im-plies, among putative mechanisms, an increase in proliferation through overexpression of ACVR2B, as also recently demonstrated in kidney cancer [19]. LHX2 has been also shown to function as an oncogene in several cancer types, being non-small-cell lung carcinoma one among others where the regulation of LHX2 gene expression is under control of microRNAs [20].…”

Section: Discussionsupporting

confidence: 80%

Proposal of a Panel of Genes Identified by miRNA Profiling as Candidate Prognostic Biomarkers in Lung Carcinoids

et al. 2020

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Aim: To validate the prognostic role of a panel of genes previously uncovered by our group to be specific targets of miRNAs differentially expressed in lung carcinoids with aggressive pathological features. Methods: Four genes, namely, cyclic AMP response element binding protein-1 (CREBP1), activin A receptor type 2B (ACVR2B), LIM homeobox 2 (LHX2), and Krüppel-like factor 12 (KLF12), were identified in a previous study by our group using in silico analysis to be regulated by 3 miRNAs (miR-409-3p, miR-409-5p, and miR-431-5p) that were shown to be downregulated in aggressive lung carcinoids. These genes were analyzed using real-time PCR in a cohort of 102 lung carcinoids. Fifty high-grade lung carcinomas served as control group. Their expression was correlated with the expression of miR-409-3p, miR-409-5p, and miR-431-5p and with clinical pathological parameters and disease-free survival. Results: The expression of all but CREBP1 gene was significantly different between lung carcinoids and high-grade neuroendocrine carcinomas. ACVR2B and LHX2 were significantly inversely correlated with miR-409-3p and miR-409-5p. High levels of ACVR2B and LHX2 were significantly associated with atypical histotype, high tumor grade, and higher proliferation Ki-67 index (all p < 0.05). Low levels of KLF12 were significantly associated with the presence of necrosis and positive nodal status (all p < 0.05). Finally, low KLF12 expression was associated with shorter disease-free survival in lung carcinoids as a whole and in atypical carcinoids, only (all p < 0.001). Conclusions: ACVR2B, LHX2, and KFL12 are novel potential biomarkers associated with aggressive features in lung carcinoids.

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Section: Discussionsupporting

confidence: 80%

Proposal of a Panel of Genes Identified by miRNA Profiling as Candidate Prognostic Biomarkers in Lung Carcinoids

et al. 2020

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“…For example, binding of ACVR2B to its ligand activin can activate the transcription of genes that inhibit muscle growth and is probably responsible for cancer-related cachexia [25, 26]. ACVR2B has also been reported to be a member of the MALAT1/miR-194-5p/ ACVR2B signaling axis, which promotes clear cell kidney carcinoma (KIRC) progression [27]. In our study, ACVR2B-AS1 was associated with poorer prognosis, although it remains unknown if and how ACVR2B-AS1 might regulate tumorigenesis and progression via the mechanisms we mentioned above.…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer

Nie

Jiao

et al. 2019

BioMed Research International

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A refined liver cancer staging system and effective prognostic prediction can help clinicians make optimized treatment decisions, which is essential in our fight against cancer and for improving the unsatisfying survival rate of liver cancer globally. The prognosis of liver cancer is not only related to tumor status, it is also affected by the patients' liver functions and the chosen treatment. Currently, several staging systems are being tested. Herein, we analyzed RNA-seq data from the TCGA database and identified a newly annotated lncRNA, ACVR2B-AS1, whose expression is upregulated in liver cancer. Higher ACVR2B-AS1 expression is an independent adverse prognostic factor for overall survival (OS) and relapse-free survival (RFS) in liver cancer patients. Our work suggests that the lncRNA ACVR2B-AS1 could be a candidate biomarker for liver cancer prognosis. Furthermore, ACVR2B-AS1 might serve as a potential therapeutic target, which is a possibility that is worthy of further study.

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“…Additionally, a Spanish study of 110 patients undergoing surgery for colorectal cancer revealed that miR-17-5p had a trend to correlate with disease-free survival at early stages,37 A meta-analysis revealed that the increased expression of miR-17 is associated with unfavorable prognoses for colon cancer. MiR-194-5p, miR-181a-5p, miR-494-3p and miR-491-3p are also reported as prognosis biomarkers in clear cell kidney carcinoma, ovarian cancer, lung (breast) cancer, and tongue cancer patients, respectively 33,38–41. Tumor suppressive miR-296-3p and miR-186-5p also affect tumorigenesis of non-small cell lung cancer and colorectal cancer cells 42,43.…”

Section: Discussionmentioning

confidence: 99%

<p>The role of PEG3 in the occurrence and prognosis of colon cancer</p>

Zhou¹,

Lin²,

Zhu³

et al. 2019

OTT

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Purpose Imprinted genes are often identified as key players in the etiology and prognosis of many tumors; however, the role they play in colon cancer remains unclear. Along with the development of big data analysis came the discovery of a wealth of genetic prognostic factors, like microsatellite instability for colon cancer, which need to be taken into consideration when evaluating new biomarkers for the disease. Methods We systematically mined public databases to find recurrence free survival (RFS)-related imprinted genes for colon cancer patients on the mRNA level by univariate and multivariate survival analyses. We then investigated the association of methylation status and microRNA expression of the targeted imprinted genes with survival rate of colon cancer patients. Lastly, in a clinical study we used qRT-PCR and immunohistochemistry to quantify mRNA and protein expression of the imprinted genes that related to RFS in our bioinformatics screening, respectively, in 20 tumor tissues compared to paired adjacent tissues. Results The results show that paternally expressed gene 3 (PEG3) is the only imprinted gene related to colon cancer patient prognosis on the mRNA level in our datasets, and high mRNA expression of PEG3 is associated with a poor prognosis. Furthermore, the methylation beta value of cg13960339, as well as the expression of 4 microRNAs, negatively correlated with PEG3 mRNA level and were correlated with the prognosis of colon cancer patients. Moreover, the expression of PEG3 mRNA in colon cancer is significantly lower, but PEG3 protein expression is significantly higher compared to that in normal tissues. Conclusion PEG3 is likely associated with the progression and prognosis of colon cancer.

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LncRNA MALAT1 modified progression of clear cell kidney carcinoma (KIRC) by regulation of miR‐194‐5p/ACVR2B signaling

Cited by 43 publications

References 48 publications

Proposal of a Panel of Genes Identified by miRNA Profiling as Candidate Prognostic Biomarkers in Lung Carcinoids

Proposal of a Panel of Genes Identified by miRNA Profiling as Candidate Prognostic Biomarkers in Lung Carcinoids

Investigation of the Clinical Significance and Prognostic Value of the lncRNA ACVR2B-As1 in Liver Cancer

<p>The role of PEG3 in the occurrence and prognosis of colon cancer</p>

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