DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.

Kashiwagi, Hirokazu; Kijima, Hiroshi; Dowaki, Shoichi; Ohtani, Yasuo; Tobita, Kosuke; Tsukui, Masaru; Tanaka, Yutaka; Matsubayasi, H; Tsuchida, Takashi; Yamazaki, Hitoshi; Nakamura, Masato; Ueyama, Yoshito; Tanaka, Makiko; Tajima, Tomoo; Makuuchi, Hiroyasu

doi:10.3892/ijo.16.3.455

Cited by 20 publications

(15 citation statements)

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“…Furthermore, MUC1 associates with Cbl-interacting protein of 85 kDa (CIN85) and colocalizes to the invadopodia-like structures aiding breast cancer cell invasion [63]. Such mechanisms could account for clinical findings that MUC1 overexpression leads to metastasis and poor prognosis in pancreas, gall bladder, and colon cancer patients [64–66]. …”

Section: The Functional Role Of Muc1 In Malignancymentioning

confidence: 99%

MUC1: a multifaceted oncoprotein with a key role in cancer progression

Nath

Mukherjee

2014

Trends in Molecular Medicine

645

614

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The transmembrane glycoprotein Mucin 1 (MUC1) is aberrantly glycosylated and overexpressed in a variety of epithelial cancers, and plays a crucial role in progression of the disease. Tumor-associated MUC1 differs from the MUC1 expressed in normal cells with regard to its biochemical features, cellular distribution, and function. In cancer cells, MUC1 participates in intracellular signal transduction pathways and regulates the expression of its target genes at both the transcriptional and post-transcriptional levels. This review highlights the structural and functional differences that exist between normal and tumor-associated MUC1. We also discuss the recent advances made in the use of MUC1 as a biomarker and therapeutic target for cancer.

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Section: The Functional Role Of Muc1 In Malignancymentioning

confidence: 99%

MUC1: a multifaceted oncoprotein with a key role in cancer progression

Nath

Mukherjee

2014

Trends in Molecular Medicine

645

614

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“…MAG from Schwann cells binds to MUC1, a transmembrane protein that is highly expressed and aberrantly glycosylated in pancreatic cancer cells and cell from other cancer types [145]. Elevated levels of MUC1 are associated with metastasis and poor prognosis in pancreas, gall bladder and colon cancer patients [147–149]. MUC1 has been shown to be involved in proliferation, metabolism, invasion, and angiogenesis [150].…”

Section: Other Molecules: Myelin Associated Glycoprotein (Mag) / Muc1mentioning

confidence: 99%

How Schwann cells facilitate cancer progression in nerves

Deborde

Wong

2017

Cell. Mol. Life Sci.

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Recent studies have demonstrated a critical role for nerves in enabling tumor progression. The association of nerves with cancer cells is well established for a variety of malignant tumors, including pancreatic, prostate and the head and neck cancers. This association is often correlated with poor prognosis. A strong partnership between cancer cells and nerve cells leads to both cancer progression and expansion of the nerve network. This relationship is supported by molecular pathways related to nerve growth and repair. Peripheral nerves form complex tumor microenvironments, which are made of several cell types including Schwann cells. Recent studies have revealed that Schwann cells enable cancer progression by adopting a de-differentiated phenotype, similar to the Schwann cell response to nerve trauma. A detailed understanding of the molecular and cellular mechanisms involved in the regulation of cancer progression by the nerves is essential to design strategies to inhibit tumor progression.

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“…[11][12][13][14] Considerable research data have shown that overexpression of MUC1 is associated with invasive and metastatic tumors of the gall bladder, colon, pancreas and oral epithelium. [14][15][16] Also, it was found that MUC3, i.e. its cysteine-rich domain, can promote cell migration, accelerate wound healing and inhibit apoptosis.…”

Section: Expression and Functions Of Mucinsmentioning

confidence: 99%

Interaction of extravillous trophoblast galectin-1 and mucin(s)—Is there a functional relevance?

Bojić‐Trbojević

Krivokuća

Kolundžić

et al. 2016

Cell Adhesion & Migration

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In the course of embryo implantation extensive interaction of the trophoblast with uterine tissue is crucial for adequate trophoblast invasion. This interaction is highly controlled, and it has been pointed out that a specific glycocode and changes in glycosylation may be important for successful implantation and maintenance of pregnancy. Both uterine and trophoblast cells have been shown to express cell surface glycoconjugates and sugar binding proteins, such as mucins (MUC) and galectins (gals). An increasing number of studies have investigated potential candidates interacting in this process. However, knowledge about the biochemical nature of the interactions and their importance for trophoblast cell function, and, consequently, for pregnancy outcome are still lacking. This review is aimed at deliberating the possibility that mucins, as heavily glycosylated proteins, might be among the functionally relevant galectin ligands in human trophoblast, based on both published data and our original research.

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DF3 expression in human gallbladder carcinoma: significance for lymphatic invasion.

Cited by 20 publications

References 0 publications

MUC1: a multifaceted oncoprotein with a key role in cancer progression

MUC1: a multifaceted oncoprotein with a key role in cancer progression

How Schwann cells facilitate cancer progression in nerves

Interaction of extravillous trophoblast galectin-1 and mucin(s)—Is there a functional relevance?

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