MUC1: a multifaceted oncoprotein with a key role in cancer progression

Nath, Sritama; Mukherjee, Pinku

doi:10.1016/j.molmed.2014.02.007

Cited by 643 publications

(657 citation statements)

References 113 publications

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“…In most epithelial-derived cancer cells, MUC1 is overexpressed and loses its apical polarity (36,37). In various adenocarcinoma including ESCC, MUC1 overexpression is correlated with tumor growth, lymph node metastasis and resistance to apoptosis (38), involved in multiple cancer-associated pathways. MUC1 suppresses activation of the ARF-MDM2-p53 pathway (39).…”

Section: Discussionmentioning

confidence: 99%

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

et al. 2015

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Abstract. MicroRNAs (miRNAs) are well known as important regulators in various cancer development. In the present study, we focused on the expression and biological function of miR-1291 in esophageal squamous cell carcinoma (ESCC). Compared with adjacent non-tumorous tissue samples, qRT-PCR data showed significant downregulation of miR-1291 in 54 ESCC tissue samples (P<0.05), which was also significantly associated with lymph node metastases and clinical stage (P<0.05). Cell Counting Kit-8 (CCK-8), colony formation, Transwell and flow cytometric apoptosis assays were performed to detect the effect of miR-1291 upregulation, and the results showed inhibition of the proliferation, invasion and promotion of apoptosis in EC9706 and EC-1 cells. Using bioinformatic analyses, we found that mucin 1 (MUC1) was a potential target for miR-1291. Luciferase assays were performed to reveal that miR-1291 inhibited MUC1 expression by targeting the seed region of MUC1 3'-untranslated region (3'UTR). We also found that the expression of MUC1 lacking in 3'UTR abrogated the anti-invasion and pro-apoptosis function of miR-1291. Our results demonstrated the importance of miR-1291 in targeting MUC1 for the regulation of esophagus cancer growth, invasion and apoptosis, and may be helpful for developing new targets for early diagnosis or new therapeutic targets for ESCC.

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Section: Discussionmentioning

confidence: 99%

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

et al. 2015

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“…Irradiation treatment. Cells (5x10 6 ) plated in 60-mm tissue culture dishes were cultured until ~60% confluency was achieved and then irradiated with 2-10 Gy of X-rays at a dose rate of 0.7 Gy/min using an X-ray generator (Precision X-Ray, Inc., North Branford, CT, USA). Following treatment for 1, 3, 6, 10, 16, and 20 h, cells were collected for further analyses.…”

Section: Methodsmentioning

confidence: 99%

“…Mucin 1 (MUC1) is a heterodimeric epithelial cell glycoprotein that is aberrantly overexpressed in a range of human cancer types (6). Mucin 1 protein has been implicated in various aspects of tumor development, including angiogenesis (7), proliferation (8), migration (9), survival (10) and metastasis (11).…”

Section: Introductionmentioning

confidence: 99%

Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling

2017

Oncol Lett

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Abstract. Mucin 1 (MUC1) is aberrantly overexpressed in numerous human cancer types, including hepatocellular carcinoma (HCC) and contributes to chemoresistance of tumor cells. The aim of the present study was to evaluate the possible implication of MUC1 in radioresistance of HCC cells and the underlying mechanisms. It was demonstrated that MUC1 was significantly upregulated in HCC cells following irradiation exposure, which was coupled with increased phosphorylation of signal transducer and activator of transcription 3 (STAT3). Enforced expression of MUC1 significantly (P<0.05) promoted the clonogenic survival of HCC cells following irradiation compared with empty vector-transfected cells. MUC1 overexpression resulted in >60% reduction in apoptosis induced by irradiation, as determined by Annexin-V/propidium iodide double staining and flow cytometry analysis. Furthermore, overexpression of MUC1 significantly (P<0.05) attenuated the activation of caspase-3 and poly (ADP-ribose) polymerase in response to irradiation exposure. Mechanistically, MUC1 inhibited irradiation-induced apoptosis through activation of janus kinase 2 (JAK2) and STAT3, and induction of anti-apoptotic proteins induced myeloid leukemia cell differentiation protein Mcl-1 (Mcl-1) and BCL2 like 1 (Bcl-xL). Small hairpin RNA-mediated knockdown of STAT3 or MUC1 resensitized MUC1-overexpressing cells to irradiation-induced apoptosis, which was accompanied by reduced expression of Bcl-xL and Mcl-1. Collectively, MUC1 contributes to radioresistance of HCC cells likely through activation of the JAK2/STAT3 signaling pathway and thus represents a potential target for improving radiotherapy against HCC.

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“…Is aberrantly glycosylated and overexpressed in various epithelial cancers and plays a crucial role in the progression of the disease [27]. MUC1 is often used as a diagnostic marker for metastatic progression [28].…”

Section: Muc1mentioning

confidence: 99%

Prognostic biomarkers in oral squamous cell carcinoma: a systematic review

Rivera

Oliveira

Costa

et al. 2017

Preprint

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2Prognostic biomarkers in oral squamous cell carcinoma: a systematic review ABSTRACT Over the years, several tumor biomarkers have been suggested to foresee the prognosis of oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articles reporting overall survival, disease-free survival and cause-specific survival as outcomes.Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in welldesigned clinical cohort-based studies.

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MUC1: a multifaceted oncoprotein with a key role in cancer progression

Cited by 643 publications

References 113 publications

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling

Prognostic biomarkers in oral squamous cell carcinoma: a systematic review

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