Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat

Tal, Michael; Bennett, Gary J.

doi:10.1016/0304-3940(93)90058-s

Cited by 137 publications

(44 citation statements)

References 19 publications

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“…These results were consistent with our previous work that im DM (40 mg) prior to surgical incision provided better postoperative pain relief, in a dose-dependent manner, after upper abdominal surgery, s In animal studies, DM and its metabolite dextrorphan attenuate temporal summation of nociceptive signals in the spinal dorsal horn neurons, z suppress formalin-induced nociceptive behaviour and c-los mRNA expression in rat spinal cord, 4 and reduce neuropathic pain syndromes. 16 100 mg po) did not attenuate the pain produced by topical capsaicin application or ischemia, is Pronounced pain relief was observed at a higher dose, 200 mg, but 50% of the volunteers were withdrawn from the study due to severe side effects, is These findings, however, do not necessarily conflict with ours. In Kauppila's study, the effective plasma concentration may not have achieved a sufficient level at the time of assessment by oral intake of a lower dose (100 rag).…”

Section: Discussionsupporting

confidence: 44%

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Wong

et al. 1999

Can J Anesth/J Can Anesth

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Purpose: To examine whether preincisional dextromethorphan (DM) improved analgesia after modified radical mastectomy (MRM). Methods: Sixty patients (ASA I-II) scheduled for MRM were included and randomly allocated into two groups. Patients in the treatment group (DM) received 40 mg DM and 20 mg chlorpheniramine maieate (CPM) ira, and those in the control group received 20 mg CPM im alone 30 min before skin incision. Meperidine, I mg-kg-' ira, was given for postoperative pain relief as required. The time to first meperidine injection, total meperidine consumption, worst pain score, bed-rest time, and side effects were recorded every 24 hr for 48 hr after surgery by a resident anesthesiologist on a double-blind basis. No difference was noted in worst VAS pain score. Meperidine-related side effects (nausea, vomiting, pruritus, dizziness, headache) were more frequent in the control (10/30) than in the DM group (3/30, P < 0.05). The number of patients who required meperidine injection for pain relief was lower in the DM (7/30) than in the control group (25/30, P < 0.005). No DM-or CPM-associated side effects were observed. Conclusion: Preincisional IM. DM treatment decreased postoperative pain and opioid requirement after MRM surgery.Objectif: D~terminer si I'administration pr~incision de dextrom&horphane (DM) am~liore I'analg&ie ~ la suite d'une mastectomie radicale modifi~e (MRM). M~.thodr : Soixante patientes (ASA I-II) qui devaient subir une HRM ont particip~ ~ I'&ude et ont ~t~ r~parties au hasard en deux groupes. Les patientes du groupe de traitement (DM) ont regu 40 mg de DM et 20 mg de mal~ate de chlorph~niramine (MCP) ira, et celles du groupe t~moin ont re~u 20 mg de MCP im seulement, 30 min avant l'incision cutan~e. De la m~p&idine, I mg.kg-' ira, a ~t~ administr~e sur demande apr~s l'op&ation pour soulager la douleur. Ont ~t~ enregistr& par un anesth&iologiste en service selon un mode ~ double insu : le temps &oul~ avant la premi&e injection de m~p&idine, la consommation totale de m~p&idine, la douleur la plus intense, le temps de repos au lit et les effets secondaires. R~.sultats : Un d~lai plus long avant la premi&e injection de m~p&idine (19,2 ---1,6 vs 1,5 +--0,23 h, P < 0,001) et une plus faible consornmation de rn~p&idine (0[I 0] vs 75[50] rag, m~diane [&endue interquartile], P < 0,00 I) ont &~ observ& dans le groupe DM compar~ au groupe t~moin. Le temps de repos au lit a ~t~ plus court dans le groupe DlVl que dans le groupe t~moin (I 8,0[4] vs 23,0[I 9] h, P < 0,001 ). Aucune diff&ence n'a toutefois ~t~ notre quant ~. la douleur la plus intense selon rEVA. Les effets secondaires reli~s ~ la m~p&idine (naus~es, vomissements, prurit, &ourdissements, c~phal&s) ont ~t~ plus frequents dans le groupe t~moin (10130) que dans le groupe DM (3/30, P < 0,05). Moins de patientes du groupe DM (7/30) que du groupe t~moin (25130) ont demand~ une injection de m~p&idine pour soulager la douleur, P < 0,005). On n'a pas observ~ d'effets secondaires associ~s au DH ou au MCP. Conclusion : l'administration pr~incision e...

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Section: Discussionsupporting

confidence: 44%

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Wong

et al. 1999

Can J Anesth/J Can Anesth

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“…A range of inflammatory stimuli also produce NMDA receptor antagonist-sensitive increases in the mechanical responses of dorsal horn neurones (Schaible et al, 1991;Dougherty et al, 1992;Ren et al, 1992a;Neugebauer et al, 1993) and of spinal reflexes (Woolf & Thompson, 1991;Ma & Woolf, 1985). However, mechanical hyperalgesia evoked by peripheral neuropathy in rats was not affected by treatment with dextrorphan, an NMDA receptor ion channel blocker, although thermal hyperalgesia was reversed in the same study (Tal & Bennett, 1993). Further, i.t.…”

Section: Discussionmentioning

confidence: 74%

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

Laird

Mason

Webb

et al. 1996

British J Pharmacology

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“…It was shown recently that dextrorphan alleviates neuropathic hyperalgesia in rats (Mao et al, 1993;Tal & Bennett, 1993). The release of excitatory amino acids during spinal cord ischaemia is inhibited by dextrorphan (Rokkas et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK₁ tachykinin receptor antagonists on inflammatory hyperalgesia in the rat

Ren

Iadarola

Dubner

1996

British J Pharmacology

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Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat

Cited by 137 publications

References 19 publications

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK₁ tachykinin receptor antagonists on inflammatory hyperalgesia in the rat

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Dextrorphan relieves neuropathic heat-evoked hyperalgesia in the rat

Cited by 137 publications

References 19 publications

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Preincisional dextromethorphan decreases postoperative pain and opioid requirement after modified radical mastectomy

Effects of a partial agonist and a full antagonist acting at the glycine site of the NMDA receptor on inflammation‐induced mechanical hyperalgesia in rats

An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK1 tachykinin receptor antagonists on inflammatory hyperalgesia in the rat

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An isobolographic analysis of the effects of N‐methyl‐D‐aspartate and NK₁ tachykinin receptor antagonists on inflammatory hyperalgesia in the rat