Dextrin cross linked with poly(HEMA): a novel hydrogel for colon specific delivery of ornidazole

Das, Dipankar; Das, Ranajit; Ghosh, Prahlad C.; Dhara, Santanu; Panda, Asit Baran; Pal, Sagar

doi:10.1039/c3ra44716b

Cited by 108 publications

(169 citation statements)

References 56 publications

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“…The lower R% values at pH 7.4 are probably largely contributed by the pore size decrease. These patterns bear a striking similarity to that for the IPNs shown in Figure 1(a) and suggests that the increase in drug mobility is directly related the increase in hydrogel pore size as pH decreases [25].…”

Section: Antibiotic Release Studiessupporting

confidence: 57%

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Ekici¹

2017

J. Drug

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Interpenetrating polymeric network (IPN) structures have been studied extensively as drug carriers to enhance the required therapeutic effect. In this study, IPNs were prepared in the form of cylindrical by using chitosan known to be biocompatible with the body, poly(N-isopropyl acrylamide) (PNIPAM) which has temperature-sensitive nature, and poly(N-vinyl pyrrolidone) (PVP). N,N'-methylenebisacrylamide (MBA) and glutaraldehyde (GA) were selected as crosslinkers to clamp polymer chains. GA were used in different concentration to control the network porous of the IPNs. Dynamic swelling studies were carried out at pH 1.1 and pH 7.4. Pulsatile swelling studies were performed on all IPN hydrogels to determine to what extent the hydrogels would respond to changes in environmental pH and temperature and how fast that response would be. Amoxicillin was loaded into the hydrogels, and released into buffered solutions as a function of pulsatile changes in temperature and pH. Amoxicillin was loaded into the hydrogels, and released into buffered solutions as a function of pulsatile changes in temperature and pH. The final percentage of amoxicillin released is noted to decrease as the content of GA in the hydrogel increases. Data clearly demonstrate that the use of thermosensitive IPN hydrogels can increase the release of drug molecules from hydrophilic IPNs based on PNIPAM. It can be said from these values that IPNs are intelligent hydrogels and can be thought of as potential devices for pH-and temperaturestimulated sustained delivery of drugs into physiological solutions or for other biomedical applications.

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Section: Antibiotic Release Studiessupporting

confidence: 57%

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Ekici¹

2017

J. Drug

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“…Additionally, the hydrogen bonding between carboxylate and hydroxyl group is also strengthen, which causes overall shrinkage and lesser swelling in acidic pH. Thus, swelling capability increases gradually with increase in pH which promotes better drug release in higher pH conditions [23]. This phenomena can help to minimize the drug loss in lower pH of GI tract (pH of stomach is 1.2 and retention time is approx.…”

Section: Accepted Manuscriptmentioning

confidence: 98%

“…This kind of profile can be used for specific treatment purpose where initial release of drug is required. However in general, this type of release profile potentially can cross the toxic drug-concentration level within initial hours and sub therapeutic drug concentration in later part [23]. As piperine is the most formidable bio-enhancer till date, it helps to enhance the bio-availability of other drugs by boosting the absorption from the intestine [24].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…To modify our selected vehicle F based on the results discussed above, the in-vitro system was designed in such a way so that the vehicle could be exposed to different pH with different retention time, as similar to GI tract [23]. The intension of the design such in-vitro system was to understand the effect of swelling and degradation of the vehicle during drug release.…”

Section: (B) Effect Of Ph and Drug Concentration On Release Profilementioning

confidence: 99%

“…To investigate the drug release kinetics and mechanism, the in-vitro release data were analysed using zero order equation [23].…”

Section: Characterizationmentioning

confidence: 99%

See 2 more Smart Citations

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Laha

Sharma

Majumdar

2017

Materials Science and Engineering: C

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The aim of this study is to develop electrospun gelatin nanofibers based drug delivery carrier to achieve controlled and sustainable release of hydrophobic drug (piperine) for prolonged time. To accomplish this, we devised some strategies such as sandwiching the drug loaded gelatin nanofiber mesh with another gelatin nanofiber matrix without drug (acting as diffusion barrier), sequential crosslinking and finally, a combination of both. As fabricated multilayered electrospun nanofibers mesh was first characterized in terms of degradation study, morphology, drug-polymer interactions, thermal stability followed by studying their release kinetics in different physiological pH as per the gastrointestinal tract. Our results show that with optimized diffusional barrier support and sequential crosslinking together, a zero order sustained drug release up to 48 h may be achieved with a flexibility to vary the drug loading as per the therapeutic requirements. This work lays out the possibility of systematic design of multilayer nano-fiber mesh of a biopolymer as a drug delivery vehicle for hydrophobic drugs with a desired signature of zero order release for prolonged duration.

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Antibacterial Hydrogels

et al. 2018

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Antibacterial materials are recognized as important biomaterials due to their effective inhibition of bacterial infections. Hydrogels are 3D polymer networks crosslinked by either physical interactions or covalent bonds. Currently, hydrogels with an antibacterial function are a main focus in biomedical research. Many advanced antibacterial hydrogels are developed, each possessing unique qualities, namely high water swellability, high oxygen permeability, improved biocompatibility, ease of loading and releasing drugs, and structural diversity. Here, an overview of the structures, performances, mechanisms of action, loading and release behaviors, and applications of various antibacterial hydrogel formulations is provided. Furthermore, the prospects in biomedical research and clinical applications are predicted.

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Dextrin cross linked with poly(HEMA): a novel hydrogel for colon specific delivery of ornidazole

Cited by 108 publications

References 56 publications

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Temperature-sensitive Ternary Interpenetrating Polymeric Networks for Potential Gastrointestinal Drug Release

Sustained drug release from multi-layered sequentially crosslinked electrospun gelatin nanofiber mesh

Antibacterial Hydrogels

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