Dextran stabilized iron oxide nanoparticles: Synthesis, characterization and in vitro studies

Easo, Sheeja Liza; Mohanan, P.V.

doi:10.1016/j.carbpol.2012.09.098

Cited by 82 publications

(57 citation statements)

References 39 publications

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“…The peaks due to α-glucopyranose ring deformation modes are found at 765 cm −1 and 915 cm −1 in dextran and DIO-NPs spectra. According to recent studies [6] these results confirm the presence of dextran coating on the iron oxide particles.…”

Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npssupporting

confidence: 81%

“…According to the studies on magnetic monodisperse Fe 3 O 4 nanoparticles conducted by Si et al [47] low magnetization could be due to the dextran layer on the surface and stabilization of iron particles. On the other hand, Easo and Mohanan [6] in their recent studies showed that the superparamagnetic characteristic of DIO-NPs signifies that these particles have single domains and all magnetic moments are aligned in one direction. The intensity of the OH vibration mode of crystal water at around 1640 cm −1 due to the adsorbed water molecules in the sample [42] is present in all the spectra from Figure 3.…”

Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npsmentioning

confidence: 99%

“…These include: magnetic resonance imaging (MRI), targeted drug delivery, detoxification of biological fluids, hyperthermia, catalysis, cell separation, cell labelling, cell targeting, biosensors, diagnostic medical devices, etc. [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Balaș

Ciobanu

Burtéa

et al. 2017

Metals

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Abstract:We report the synthesis of dextran-coated iron oxide magnetic nanoparticles (DIO-NPs) with spherical shape and uniform size distribution as well as their accumulation and toxic effects on Jurkat cells up to 72 h. The characterization of dextran-coated maghemite nanoparticles was done by X-ray diffraction and dynamic light scattering analyses, transmission electron microscopy imaging, attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, magnetic hysteresis, and relaxometry measurements. The quantification of DIO-NPs intracellular uptake showed a progressive accumulation of iron as a function of time and dose accompanied by additional lysosome formation and an increasing darkening exhibited by a magnetic resonance imaging (MRI) scanner. The cytotoxicity assays revealed a decrease of cell viability and a loss of membrane integrity in a time-and dose-dependent manner. Exposure to DIO-NPs determined an increase in reactive oxygen species level up to 72 h. In the first two days of exposure, the level of reduced glutathione decreased and the amount of malondyaldehyde increased, but at the end of the experiment, their concentrations returned to control values. These nanoparticles could be used as contrast agents for MRI but several parameters concerning their interaction with the cells should be taken into consideration for a safe utilization.

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Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npssupporting

confidence: 81%

Section: Atr-ftir Spectra and Magnetic Behavior Of Dio-npsmentioning

confidence: 99%

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Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Balaș

Ciobanu

Burtéa

et al. 2017

Metals

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“…19 Hence, the aim of the present study was to examine the cellular uptake, a) Author to whom correspondence should be addressed; electronic mail: mohanpv10@gmail.com cytotoxicity, and oxidative stress response induced by DIONPs exposure in human lymphocytes. Using in vitro techniques, we have tried to assess the extent of interaction of DIONPs with human peripheral blood lymphocytes.…”

Section: Introductionmentioning

confidence: 99%

Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

Easo

Mohanan

2016

Biointerphases

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Iron oxide nanoparticles present an attractive choice for carcinogenic cell destruction via hyperthermia treatment due to its small size and magnetic susceptibility. Dextran stabilized iron oxide nanoparticles (DIONPs) synthesized and characterized for this purpose were used to evaluate its effect on cellular uptake, cytotoxicity, and oxidative stress response in human peripheral blood lymphocytes. In the absence of efficient internalization and perceptible apoptosis, DIONPs were still capable of inducing significant levels of reactive oxygen species formation shortly after exposure. Although these particles did not cause any genotoxic effect, they enhanced the expression of a few relevant oxidative stress and antioxidant defense related genes, accompanied by an increase in the glutathione peroxidase activity. These results indicate that under the tested conditions, DIONPs induced only minimal levels of oxidative stress in lymphocytes. Understanding the biological interaction of DIONPs, the consequences as well as the associated mechanisms in vitro, together with information obtained from systemic studies, could be expected to advance the use of these particles for further clinical trials.

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“…The most commonly used IONP coating materials are silica, 30 polyethylene glycol, 31 dextran and its derivatives, 32 chitosan, 33 and carbon. 34 Very recently, silica-coated IONPs have been tested as contrast agents for biomedical photoacoustic imaging 35 and T1 MRI.…”

Section: Discussionmentioning

confidence: 99%

In vitro toxicity of FemOn, FemOn-SiO2 composite, and SiO2-FemOn core-shell magnetic nanoparticles

Toropova¹,

Головкин²,

Malashicheva³

et al. 2017

IJN

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Dextran stabilized iron oxide nanoparticles: Synthesis, characterization and in vitro studies

Cited by 82 publications

References 39 publications

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Synthesis, Characterization, and Toxicity Evaluation of Dextran-Coated Iron Oxide Nanoparticles

Toxicological evaluation of dextran stabilized iron oxide nanoparticles in human peripheral blood lymphocytes

In vitro toxicity of Fe<sub>m</sub>O<sub>n</sub>, Fe<sub>m</sub>O<sub>n</sub>-SiO<sub>2</sub> composite, and SiO<sub>2</sub>-Fe<sub>m</sub>O<sub>n</sub> core-shell magnetic nanoparticles

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