Dextran's regulatory effect on immunoglobulin synthesis is mediated through T cells

Battisto, Jack R.; Pappas, F

doi:10.1016/0008-8749(74)90141-5

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…It should be mentioned that the possible response of T cells to these compounds in the presence of other cell types is a situation similar to in vivo conditions and has some support in the literature. Polyanions (Cone & Johnson 1971, Yamashita & Kitagawa 1974 and dextran (Battisto & Pappas 1974) have beea reported to influence T cells, the T cell action of these compounds generally being evaluated by their influence on B cell antibody formation. However, Cone & Johnson (1971) suggested that the influence of poly A-U on the immune response of thymectomized, hone marrow reconstituted mice given small doses of T cells was via enhanced proliferation of these T cells.…”

Section: Response To Polynucleotides Results Inmentioning

confidence: 99%

Avian B Lymphocyte Subpopulations Origins and Functional Capacities

Weber

1975

Immunological Reviews

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Section: Response To Polynucleotides Results Inmentioning

confidence: 99%

Avian B Lymphocyte Subpopulations Origins and Functional Capacities

Weber

1975

Immunological Reviews

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“…Dextran was presumed to act primarily upon B cells but not on T cells [2]. However, a small number of 0positive cells is still necessary for the activation of B cells by dextran [3]. When dextran is given to mice together with TNP-erythrocytes, higher affinity-PFC is generated without any augmentation of the number of PFC in the spleen of the mice ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Modulation of Mouse Anti-Trinitrophenyl Plaque-Forming Cell Affinity by Adjuvants or Lectins

Saito

Nakano

Kumazawa

1976

Japanese Journal of Microbiology

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The effects of several kinds of adjuvants or lectins, such as Corynebacterium parvum, dextran, poly AU, poly IC, dibutyryl cAMP, concanavalin A (Con A), phytohemagglutinin (PHA) and pokeweed mitogen (PWM) on anti-trinitrophenyl (TNP) direct plaque-forming cells (PFC) in the spleen of mice and the affinity of antibodies produced by these PFC were examined. The numbers of anti-TNP PFC in the spleens of mice which had been injected with C. parvum 7 days in advance were greater than those in controls after immunization with TNP-coupled heterologous erythrocytes, while the affinity of antibodies released by these PFC was not affected. On the contrary, simultaneous injection of dextran with TNP-erythrocytes did not increase the numbers of splenic anti-TNP PFC, but heightened the affinity of antibodies released by these PFC. Copolymers of nucleotides, poly AU and poly IC, were capable of enhancing splenic anti-TNP PFC responses, but showed almost no altering of PFC affinity. Dibutyryl cAMP did not have any effect on this system. Con A had potencies to both augment the number of anti-TNP PFC and heighten the PFC affinity, while PHA seemed to lack these potencies. Injection of PWM in the presence of antigen increased the number of anti-TNP PFC and heightened slightly the PFC affinity. These results indicate that the heightening of the affinity at the cellular level is regulated in ways different from the augmenting effects on the number of anti-TNP PFC by adjuvants or lectins. These results are discussed in the light of the mode of action of the substances used.The anti-hapten antibodies secreted by antibody-producing cells (B cells) after antigenic stimulation are heterogeneous with respect to their affinity for hapten, and the antibodies with higher affinity increase with time after the stimulation [17,26,29]. The affinity of the antibody reflects the properties of B cells rather than those of T helper cells [16], but the helper cells still seem to have some influence on the alteration of the affinity of anti-hapten antibodies [9,18,30,31]. Injection of complete Freund's adjuvant or bacterial lipopolysaccharide (LPS) concomitantly with antigen results in a heightening of the affinity of serum antibody [20]. LPS is known not only to be a powerful adjuvant [21] but also to have a potency as a polyclonal activator [22].Our previous studies [27] indicated that LPS in the presence of antigenic stimulation has some effect on hapten-specific B precursors in heightening the affinity or in selecting high affinity antibody-producing progeny cells, but the alteration of antibody affinity and the increase in number of antibody-producing cells induced by LPS are regulated by different mechanisms. There are many other adjuvants and mitogens such as Corynebacterium parvum, dextran, polynucleotides and lectins, which can stimulate T or B cells specifically and result in augmentation of immune responses. To examine whether these substances affect the affinity of antibodies secreted from antigenstimulated anti-hapten antibody-pr...

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Immunological Responses to Bacterial Plaque in the Mouth

Lehner

1976

Ciba Foundation Symposium 46 ‐ Immunology of the Gut

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Dextran's regulatory effect on immunoglobulin synthesis is mediated through T cells

Cited by 8 publications

References 16 publications

Avian B Lymphocyte Subpopulations Origins and Functional Capacities

Avian B Lymphocyte Subpopulations Origins and Functional Capacities

Modulation of Mouse Anti-Trinitrophenyl Plaque-Forming Cell Affinity by Adjuvants or Lectins

Immunological Responses to Bacterial Plaque in the Mouth

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