Dextran-Gated, Multifunctional Mesoporous Nanoparticle for Glucose-Responsive and Targeted Drug Delivery

Sinha, Arjyabaran; Chakraborty, Atanu; Jana, Nikhil R.

doi:10.1021/am505848p

Cited by 69 publications

(60 citation statements)

References 47 publications

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“…In addition, in terms of drug release, the nanocarrier can be used to satisfy different needs of treament. According to the literature, the pure β-CD [42,43] or MNPs [44,45] …”

Section: Cellular Uptake and In Vitro Cytotoxicitymentioning

confidence: 99%

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Wang

Huang

Shi

et al. 2015

Applied Surface Science

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“…In addition, in terms of drug release, the nanocarrier can be used to satisfy different needs of treament. According to the literature, the pure β-CD [42,43] or MNPs [44,45] …”

Section: Cellular Uptake and In Vitro Cytotoxicitymentioning

confidence: 99%

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Wang

Huang

Shi

et al. 2015

Applied Surface Science

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“…The percentage release values observed and the release rates are broadly in agreement with the literature. [49][50][51] of these two materials (ie, had a lower LCST) and further, since AAPBA is very expensive, is more cost-effective than PAD-2-1. PAD-5-1 was thus taken forward into further work.…”

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confidence: 99%

Glucose- and temperature-sensitive nanoparticles for insulin delivery

Wu¹,

Williams²,

Li³

et al. 2017

IJN

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Glucose- and temperature-sensitive polymers of a phenylboronic acid derivative and diethylene glycol dimethacrylate (poly(3-acrylamidophenyl boronic acid- b -diethylene glycol methyl ether methacrylate); p(AAPBA- b -DEGMA)) were prepared by reversible addition–fragmentation chain transfer polymerization. Successful polymerization was evidenced by 1 H nuclear magnetic resonance and infrared spectroscopy, and the polymers were further explored in terms of their glass transition temperatures and by gel permeation chromatography (GPC). The materials were found to be temperature sensitive, with lower critical solution temperatures in the region of 12°C–47°C depending on the monomer ratio used for reaction. The polymers could be self-assembled into nanoparticles (NPs), and the zeta potential and size of these particles were determined as a function of temperature and glucose concentration. Subsequently, the optimum NP formulation was loaded with insulin, and the drug release was studied. We found that insulin was easily encapsulated into the p(AAPBA- b -DEGMA) NPs, with a loading capacity of ~15% and encapsulation efficiency of ~70%. Insulin release could be regulated by changes in temperature and glucose concentration. Furthermore, the NPs were non-toxic both in vitro and in vivo. Finally, the efficacy of the formulations at managing blood glucose levels in a murine hyperglycemic diabetes model was studied. The insulin-loaded NPs could reduce blood glucose levels over an extended period of 48 h. Since they are both temperature and glucose sensitive and offer a sustained-release profile, these systems may comprise potent new formulations for insulin delivery.

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“…Silicon and its oxides, especially mesoporous silica materials (MSMs) are widely used as biomaterials due to the biocompatible and modifying properties [37,38]. Mesoporous silica nanoparticles, with large capacity for drug loading, tailorable mesoporous structure, and modification properties, have attracted intense interest for use as glucose-sensitive self-regulated drug delivery carriers [39,40,41]. The MSN-based double-drug delivery system was designed to control the release of gluconic acid-modified insulin (G-Ins) and cyclic adenosine monophosphate (cAMP) triggered by glucose.…”

Section: Pba-functionalized Materials and Polymersmentioning

confidence: 99%

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

Huang

Liu

et al. 2017

Materials

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In recent years, glucose-sensitive drug delivery systems have attracted considerable attention in the treatment of diabetes. These systems can regulate payload release by the changes of blood glucose levels continuously and automatically with potential application in self-regulated drug delivery. Boronic acid (BA), especially phenylboronic acid (PBA), as glucose-sensitive agent has been the focus of research in the design of glucose-sensitive platforms. This article reviews the previous attempts at the developments of PBA-based glucose-sensitive drug delivery systems regarding the PBA-functionalized materials and glucose-triggered drug delivery. The obstacles and potential developments of glucose-sensitive drug delivery systems based on PBA for diabetes treatment in the future are also described. The PBA-functionalized platforms that regulate drug delivery induced by glucose are expected to contribute significantly to the design and development of advanced intelligent self-regulated drug delivery systems for treatment of diabetes.

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Dextran-Gated, Multifunctional Mesoporous Nanoparticle for Glucose-Responsive and Targeted Drug Delivery

Cited by 69 publications

References 47 publications

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Targeted delivery and pH-responsive release of stereoisomeric anti-cancer drugs using β-cyclodextrin assemblied Fe3O4 nanoparticles

Glucose- and temperature-sensitive nanoparticles for insulin delivery

Boronic Acid as Glucose-Sensitive Agent Regulates Drug Delivery for Diabetes Treatment

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